ビス(4-ヒドロキシベンゼンスルホン酸)亜鉛

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

5.4 [mg/m3]

59 [mg/m3]

360 [mg/m3]

Dust mask; goggles or face shield; protective gloves (USCG, 1999)

/NIOSH certified respirator/; goggles or face shield; protective gloves. /Octahydrate/

Safe in the present practices of use and concentration. Ingredient, concentration, and use information are available in documents discoverable at https://cir-reports.cir-safety.org

Anaemia results from the excessive absorption of zinc suppressing copper and iron absorption, most likely through competitive binding of intestinal mucosal cells. Unbalanced levels of copper and zinc binding to Cu,Zn-superoxide dismutase has been linked to amyotrophic lateral sclerosis (ALS). Stomach acid dissolves metallic zinc to give corrosive zinc chloride, which can cause damage to the stomach lining. Metal fume fever is thought to be an immune response to inhaled zinc. (L48, L49, A49)

Ingestion of large doses of zinc causes stomach cramps, nausea, and vomiting. Acute inhalation of large amounts of zinc causes metal fume fever, which is characterized by chills, fever, headache, weakness, dryness of the nose and throat, chest pain, and coughing. Dermal contact with zinc results in skin irritation. (L49)

A single instance has been reported in which use of a 3% /zinc phenolsufonate/ soln in eye compresses resulted in complete necrosis of both corneas of an infant.

Subjects using 30 mM zinc phenolsulfonate as a mouthwash retained 12% of the zinc. Salivary zinc concn was increased using mouthwashes containing 17-35 mM zinc as zinc sulfonate, zinc phenolsulfonate, or zinc citrate. At 17 mM, the effect lasted 3-4 hr. Zinc retained in the mouth gave visible fluorescence after rinsing with 8-hydroxyquinoline, and this was particularly evident on the tongue, cheek mucosa, and dental plaque. The concn of zinc in plaque was increased 13 19 fold 1 hr after using 31 or 18 mM zinc phenolsulfonate. The effect of zinc on the metabolic activity of plaque may reduce the growth rate of plaque bacteria and so decrease plaque growth.

Basic treatment: Establish a patent airway. Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Anticipate seizures and treat if necessary ... . Monitor for shock and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with normal saline during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 mg/kg up to 200 mL of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool. Administer activated charcoal ... . Cover skin burns with sterile dressings after decontamination ... . /Sulfur and related compounds/

Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious. Early intubation at the first sign of upper airway obstruction may be necessary. Monitor cardiac rhythm and treat arrhythmias if necessary ... . Start an IV with D5W TKO /SRP: "To keep open", minimal flow rate/. Use lactated Ringer's if signs of hypovolemia are present. Watch for signs of fluid overload. Consider drug therapy for pulmonary edema ... . Treat seizures with diazepam (Valium) ... . For hypotension with signs of hypovolemia, administer fluid cautiously. Consider vasopressors for hypotension with a normal fluid volume. Watch for signs of fluid over load ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Sulfur and related compounds/

LC (rat) > 208,000 mg/m3/1h

LD50: 1800 mg/kg (Oral, Rat) (T14) LD50: 225 mg/kg (Intraperitoneal, Mouse) (T14)

LD50 Oral Rat 1800 mg/kg

LD50 Oral Mouse 3 g/kg

LD50 ip Mouse 225 mg/kg

Persons in charge of vessels or facilities are required to notify the National Response Center (NRC) immediately, when there is a release of this designated hazardous substance, in an amount equal to or greater than its reportable quantity of 5000 lb or 2270 kg. The toll free number of the NRC is (800) 424-8802; In the Washington D.C. metropolitan area (202) 426-2675. The rule for determining when notification is required is stated in 40 CFR 302.4 (section IV. D.3.b).

Designated as a hazardous substance under section 311(b)(2)(A) of the Federal Water Pollution Control Act and further regulated by the Clean Water Act Amendments of 1977 and 1978. These regulations apply to discharges of this substance.

Toxic pollutant designated pursuant to section 307(a)(1) of the Clean Water Act and is subject to effluent limitations. /Zinc and cmpds/

For total recoverable zinc the criterion-to protect freshwater aquatic life ... is 47 ng/l as a 24 hr average ... at hardnesses of 50, 100, and 200 mg/l as CaCO3 the concentration of total recoverable zinc should not exceed 180, 320, 570 ug/l at any time. /Soluble zinc salts/

For total recoverable zinc the criterion to protect saltwater aquatic life ... is 58 ug/l as a 24 hr average and the concentration should not exceed 170 ug/l at any time. /Soluble zinc salts/

EPA 5000 ug/l /Zinc/

EPA 2000 ug/l /Zinc, Lifetime health advisory/