基本情報
- CAS
22760-18-5- 標準SMILES
Cc1ccc2c(-c3ccccc3)nc(=O)n(C(C)C)c2c1- InChIKey
JTIGKVIOEQASGT-UHFFFAOYSA-N- 分子式
- C18H18N2O
- 平均分子量
- 278.3 g/mol
- 単同位体質量
- 278.1419132
概要
Proquazone is a member of pyrimidines.
名称と識別子
- 優先名称
- Proquazone
- IUPAC
- 7-methyl-4-phenyl-1-propan-2-ylquinazolin-2-one
- 現地名
- プロクアゾン
- 英語名
- proquazone
- 分子式
- C18H18N2O
- 分子量
- 278.35
名称と別名
PROQUAZONE22760-18-5ArthrexProquazonumProcuazona42VPJ2980SDTXSID4021210RefChem:8698751-isopropyl-4-phenyl-7-methyl-2-(1H)-quinazolineDTXCID801210M01AX13245-203-7
名称をさらに表示
プロクアゾンビアリソン1-イソプロピル-7-メチル-4-フェニルキナゾリン-2(1H)-オンプロカゾンビアルサンプロクァゾン7-メチル-4-フェニル-1-(プロパン-2-イル)-1,2-ジヒドロキナゾリン-2-オン43-715BiarsanSaH-43-715ProquazonaSandoz-43-715Proquazone, 10 mM in DMSO
7-Methyl-1-(1-methylethyl)-4-phenyl-2(1H)-quinazolinone7-methyl-4-phenyl-1-propan-2-ylquinazolin-2-one1-isopropyl-7-methyl-4-phenylquinazolin-2(1H)-one2(1H)-Quinazolinone, 1-isopropyl-7-methyl-4-phenyl-Biarison1-Isopropyl-7-methyl-4-phenyl-2(1H)-quinazolinone7-methyl-4-phenyl-1-(propan-2-yl)-1,2-dihydroquinazolin-2-oneAnthrex; Biarison;RU 43-715; SAN 43-715
データベース識別子
- CAS
22760-18-5- PubChem CID
- 31508
- DTXSID
DTXSID4021210
物性
構造計算による物性
- XLogP
- 3
- 極性表面積
- 32.7 Ų
- 水素結合供与体数
- 0
- 水素結合受容体数
- 1
- 回転可能結合数
- 2
- 重原子数
- 21
- 形式電荷
- 0
- 複雑度
- 423
実験および物理化学的性質
Human DrugsPharmaceuticals
物理化学的性質
- 融点
- 137 · 137-138°
- 沸点
- 436.12 °C · 436.12°C (rough estimate)
- 比重(密度)
- 1.1707 · 1.1707 (rough estimate)
- 屈折率
- 1.57 · 1.5700 (estimate)
- 酸解離定数(Pka)
- 0.74 · 0.74±0.20(Predicted)
化学と産業
薬理情報
ATC Code
M - Musculo-skeletal system
QM - Musculo-skeletal system
MeSH Pharmacological Classification
Compounds capable of relieving pain without the loss of CONSCIOUSNESS.
Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects.
Compounds or agents that combine with cyclooxygenase (PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES) and thereby prevent its substrate-enzyme combination with arachidonic acid and the formation of eicosanoids, prostaglandins, and thromboxanes.
用途と製造
Use ClassificationPharmaceuticals
応用分野
使用Proquazone is a non-steroidal anti-inflammatory drug.
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