ジプロフィリン

-1.9

-1.25

CRYSTALS FROM ALCOHOL

WHITE AMORPHOUS SOLID

FREELY SOL IN WATER; 1 G IN 3 ML H2O @ 25 °C

SOL IN ALC: 2 G/100 ML; IN CHLOROFORM: 1 G/100 ML

1.43e+01 g/L

>38.1 [ug/mL] (The mean of the results at pH 7.4)

Breast Feeding; Lactation; Milk, Human; Anti-Asthmatic Agents; Bronchodilator Agents

FDA approved drugs -> Active ingredient

FDA approved drugs -> Active ingredient

Pharmaceuticals

155-157

158 °C

161.5 °C

Warning

H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]

P261, P264, P270, P271, P301+P317, P304+P340, P317, P330, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 61 reports by companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Danger

H302: Harmful if swallowed [Warning Acute toxicity, oral]

Acute Tox. 4 (100%)

Acute toxicity (Oral) - Category 4

METHYLXANTHINES CAN ALSO ANTAGONIZE EFFECTS OF HYPOPROTHROMBINEMIA CAUSED BY COUMARIN DERIV... /METHYLXANTHINES/

XANTHINES CAN MARKEDLY POTENTIATE CARDIAC INOTROPIC RESPONSES TO BETA-ADRENERGIC AGONISTS & TO GLUCAGON. /XANTHINES/

PARENTERALLY ADMIN THEOPHYLLINE...INCR RATE & DEPTH OF RESP... AFTER ADMIN OF LARGE AMT OF...THEOPHYLLINE, ENTIRE CNS, INCL SPINAL CORD, IS STIMULATED. REFLEX EXCITABILITY IS INCR, & LOWER MOTOR CENTERS MAY BE DIRECTLY EXCITED. /THEOPHYLLINE/

THEOPHYLLINE...CAN BE QUITE TOXIC & HAS OCCASIONALLY PROVED FATAL. /THEOPHYLLINE/

GREAT CARE...MUST BE EXERCISED WHEN /SALTS OF XANTHINES/...ARE ADMIN /IV/... ESP IN PT WITH SEVERE MYOCARDIAL DAMAGE, FOR HIGH LOCAL CONCN MAY RESULT IN PPT OF FREE ALKALOIDS WHEN SALTS ARE EXPOSED TO PH OF BLOOD. ...SHARP, USUALLY TRANSIENT, FALL IN BLOOD PRESSURE...WHEN INJECTION IS TOO RAPID. /XANTHINE SALTS/

R - Respiratory system

QR - Respiratory system

Dyphylline, a xanthine derivative, is a bronchodilator used for relief of acute bronchial asthma and for reversible bronchospasm associated with chronic bronchitis and emphysema. Dyphylline is a xanthine derivative with pharmacologic actions similar to theophylline and other members of this class of drugs. Its primary action is that of bronchodilation, but it also exhibits peripheral vasodilatory and other smooth muscle relaxant activity to a lesser degree.

The bronchodilatory action of dyphylline, as with other xanthines, is thought to be mediated through competitive inhibition of phosphodiesterase with a resulting increase in cyclic AMP producing relaxation of bronchial smooth muscle as well as antagonism of adenosine receptors.

THEIR MOST IMPORTANT ACTION...IS THEIR ABILITY TO RELAX SMOOTH MUSCLES OF BRONCHI... THEOPHYLLINE IS MOST EFFECTIVE... /THEOPHYLLINE/

ACTION OF XANTHINES ON MOTOR ACTIVITY OF GI TRACT... DILUTE SOLN INCR, & HIGH CONCN DEPRESS, TONE & STRENGTH OF CONTRACTION OF ISOLATED INTESTINAL STRIPS. /XANTHINES/

...ACTION SEEMS TO RESULT FROM INCR IN CONCN OF FACTOR V (AC-GLOBULIN) IN PLASMA WHICH, IN TURN, MAY BE CAUSED BY INCR IN PLASMA CONCN OF FREE FATTY ACIDS PRODUCED...THERE ARE ALSO INCR IN CONCN OF CIRCULATING PROTHROMBIN & FIBRINOGEN. /XANTHINES/

...ACCOMPANYING DECR IN VENOUS FILLING PRESSURE, WHICH IS CAUSED @ LEAST PARTLY BY MORE COMPLETE EMPTYING OF HEART. /THEOPHYLLINE/

Hepatic

IN BODY XANTHINES ARE ONLY PARTIALLY DEMETHYLATED & OXIDIZED. THEY ARE LARGELY EXCRETED AS METHYLURIC ACIDS OR AS METHYLXANTHINES. /XANTHINES/