基本情報
- CAS
161448-79-9- 標準SMILES
CCCNC(C)C(=O)Nc1c(C)csc1C(=O)OC.Cl- InChIKey
GDWDBGSWGNEMGJ-UHFFFAOYSA-N- 分子式
- C13H21ClN2O3S
- 平均分子量
- 320.84 g/mol
- 単同位体質量
- 320.0961414
概要
Articaine Hydrochloride is the hydrochloride salt form of articaine, an amide-type local anesthetic. Articaine hydrochloride reversibly blocks nerve impulse conduction by binding to specific membrane sodium ion channels thereby interfering with the electrical excitation in the nerve, slowing the propagation of the nerve impulse and reducing the rate of rise of the action potential. This results in a loss of sensation at the injection site. Articaine hydrochloride is used for relief of pain in minor operations, usually in combination with the vasoconstrictor epinephrine.
名称と識別子
- 優先名称
- Articaine Hydrochloride
- IUPAC
- methyl 4-methyl-3-[2-(propylamino)propanoylamino]thiophene-2-carboxylate;hydrochloride
名称と別名
ARTICAINE HYDROCHLORIDE23964-57-0Articaine HClUltracainSeptanestUltracaineUbistesineHoe-045HOE 045HOE 40045DTXSID2045444Hoe-40045
名称をさらに表示
QS9014Q792DTXCID00254444-Methyl-3-(2-(propylamino)propionamido)-2-thiophenecarboxylic acid methyl ester HCl2-Thiophenecarboxylic acid, 4-methyl-3-((1-oxo-2-(propylamino)propyl)amino)-, methyl ester, monohydrochlorideRefChem:916258Hoe045Hoe40045245-957-7
データベース識別子
- CAS
161448-79-9、23964-57-0- PubChem CID
- 32169
- DTXSID
DTXSID2045444- ChEMBL
CHEMBL1200819- UNII
- QS9014Q792
- EC Number
- 245-957-7
物性
構造計算による物性
- 極性表面積
- 95.7 Ų
- 水素結合供与体数
- 3
- 水素結合受容体数
- 5
- 回転可能結合数
- 7
- 重原子数
- 20
- 形式電荷
- 0
- 複雑度
- 325
実験および物理化学的性質
Human Drugs
Breast Feeding; Lactation; Milk, Human; Anesthetics, Local
FDA approved drugs -> Active ingredient
FDA approved drugs -> Active ingredient
安全と法規制
安全情報は参考情報です。供給元の安全データシート（SDS）、適用法令、専門家による評価に代わるものではありません。
GHS分類
GHS Classification
Warning
H302 (80.6%): Harmful if swallowed [Warning Acute toxicity, oral]
P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 216 reports by companies from 11 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
危険有害性情報
Hazard Classes and CategoriesAcute Tox. 4 (80.6%)
毒性情報
Effects During Pregnancy and Lactation◉ Summary of Use during Lactation
化学と産業
薬理情報
FDA Pharmacological Classification
ARTICAINE HYDROCHLORIDE
Local Anesthesia [PE]; Amide Local Anesthetic [EPC]; Amides [CS]
MeSH Pharmacological Classification
Drugs that block nerve conduction when applied locally to nerve tissue in appropriate concentrations. They act on any part of the nervous system and on every type of nerve fiber. In contact with a nerve trunk, these anesthetics can cause both sensory and motor paralysis in the innervated area. Their action is completely reversible. (From Gilman AG, et. al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed) Nearly all local anesthetics act by reducing the tendency of voltage-dependent sodium channels to activate.
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