化工社化工社 化学情報印刷レポート · 研究参考用
ジチオりん酸O-エチルS,S-ジプロピル
エトプロップ · モーキャップ · エトプロホス · ローキャップ · プロホス · ジチオりん酸O-エチルS,S-ジプロピル · ロボキル · モカップ10G
識別子と物理属性
| CAS No. | 13194-48-4 |
|---|---|
| 分子式 | C8H19O2PS2 |
| 平均分子量 | 242.3 g/mol |
| 単同位体質量 | 242.05640919 g/mol |
| SMILES | CCCSP(=O)(OCC)SCCC |
| InChIKey | VJYFKVYYMZPMAB-UHFFFAOYSA-N |
| PubChem CID | 3289 |
| ChEMBL | CHEMBL1894994 |
| ChEBI | CHEBI:38665 |
| EC No. | 236-152-1 |
| DTXSID | DTXSID4032611 |
| 現地名 | ジチオりん酸O-エチルS,S-ジプロピル |
化学・物理的性質
| XLogP | 3.6 |
|---|---|
| 極性表面積 | 76.9 |
| 水素結合供与体数 | 0 |
| 水素結合受容体数 | 4 |
| 回転可能結合数 | 8 |
| 重原子数 | 13 |
| 形式電荷 | 0 |
| 複雑度 | 152 |
| LogP（分配係数） | log Kow = 3.59 @ 21 °C3.6 |
| 密度 | 1.094 at 68 °F (EPA, 1998) - Denser than waterwill sink1.094 g/cu cm @ 20 °CRelative density (water = 1): 1.091.09 @ 20°Cd420 1.094 |
| Color/Form | Pale yellow liquidPale yellow oil |
| 溶解度 | Readily sol in most organic solventsSOLUBLE IN KEROSENESolubility >300 g/kg @ 20 °C in acetone, ethanol, xylene, 1,2-dichloroethane, diethyl ether, ethyl acetate, petroleum spirit, cyclohexaneIn water, 750 mg/l @ 20-25 °CSolubility in water, g/100ml at 20 °C: 0.075DMF: 5mg/mLDMSO: 5mg/mLEthanol: 1.6mg/mL700 mg l-1 (20 °C) |
| Corrosivity | Non-corrosive to metals |
| 沸点 | 187 to 196 °F at 0.2 mmHg (EPA, 1998)86-91 °C @ 0.2 mm Hgat 0.03kPa: 86-91 °C86-91°C |
| Decomposition | When heated to decomposition it emits very toxic fumes of /phosphorus oxides and sulfur oxides/.room temperature. This produces flammable n-propylmercaptan (see ICSC 1492). Decomposes on heating. This produces toxic fumes including phosphorus oxides and sulfur oxides. |
| 融点 | -13 °C |
| 蒸気密度 | Relative vapor density (air = 1): 8.4 |
| 蒸気圧 | 0.00035 mmHg at 78.8 °F (EPA, 1998)0.00035 [mmHg]3.8X10-4 mm Hg @ 20-25 °CVapor pressure, Pa at 20-25 °C: 0.050.00038 [mm Hg] @25 °C4.65 x 10-2 Pa (26 °C) |
| Physical Description | Ethorop is one of a family of organophosphorus pesticides. It is combustible though it may require some effort to ignite. It is very toxic by skin absorption and inhalation. It may or may not be water soluble.Pale yellow liquid[Merck Index] Colorless to yellow liquid with a strong odor of mercaptans[Reference #1]PALE YELLOW LIQUID WITH CHARACTERISTIC ODOUR. |
| Stability/Shelf Life | Very stable in neutral and weakly acidic media. Rapidly hydrolysed in alkaline media. Stable in water up to 100 °C at pH 7.... Thermally stable for 8 hr at 150 °C. |
| 引火点 | 100 °C |
| 貯蔵条件 | APPROX 4°C |
| Merck | 13,3782 |
| BRN | 8139788 |
| ヘンリー定数 | 6.1×101 mol/(m3Pa) at 25℃, HSDB (2015) |
| 安定性 | Hygroscopic |
| 主な用途 | 農業環境 |
| InChI | 1S/C8H19O2PS2/c1-4-7-12-11(9,10-6-3)13-8-5-2/h4-8H2,1-3H3 |
| InChIKey | VJYFKVYYMZPMAB-UHFFFAOYSA-N |
| SMILES | CCCSP(=O)(OCC)SCCC |
| CAS データベース | 13194-48-4(CAS DataBase Reference) |
| NISTの化学物質情報 | Ethoprophos(13194-48-4) |
| EPAの化学物質情報 | Ethoprop (13194-48-4) |
化学的特性
Ethoprophos is a pale yellow liquid.
安全性と法規制
| GHS 分類 | DangerH301: Toxic if swallowed [Danger Acute toxicity, oral]H310: Fatal in contact with skin [Danger Acute toxicity, dermal]H317: May cause an allergic skin reaction [Warning Sensitization, Skin]H330: Fatal if inhaled [Danger Acute toxicity, inhalation]H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]P260, P261, P262, P264, P270, P271, P272, P273, P280, P284, P301+P316, P302+P352, P304+P340, P316, P320, P321, P330, P333+P317, P361+P364, P362+P364, P391, P403+P233, P405, and P501 (click each P-code to see the statement) |
|---|---|
| 規制情報 | Hazard Traits - CarcinogenicityEnvironmental toxAuthoritative List - CWA 303(d)Prop 65Report - regardless of intended function of ingredient in the productRegulation (EC) No 1107/2009 (amended)Ethoprop is listed in the dataset of EPA Human Health Benchmarks for Pesticides under the Safe Drinking Water Act (40 eCFR 141)07/52/EC, Reg. (EU) 2018/917, Reg. (EU) 2019/344, Reg. (EU) No 1178/2013, Reg. (EU) No 540/2011Status: Active Update: 30-05-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/33573The New Jersey Worker and Community Right to Know Act requires public and private employers to provide information about hazardous substances at their workplaces. (N.J.S.A. 34:5A-1 et. seq.) |
| その他の安全情報 | IMAP assessments - Phosphorodithioic acid, O-ethyl S,S-dipropyl ester: Human health tier I assessmentIMAP assessments - Phosphorodithioic acid, O-ethyl S,S-dipropyl ester: Environment tier I assessment |
| 輸送ラベル（DOT） | Poison |
| 火災危険 | (Non-Specific -- Organophosphorus Pesticide, Liquid, n.o.s.) Container may explode in heat of fire. Fire and runoff from fire control water may produce irritating or poisonous gases. Stable in water. Hydrolyzed in alkali. (EPA, 1998)Combustible. Gives off irritating or toxic fumes (or gases) in a fire. Heating will cause rise in pressure with risk of bursting. |
| 健康有害性 | This material is extremely toxicthe probable oral lethal dose for humans is 5-50 mg/kg, or between 7 drops and 1 teaspoonful for a 150 lb. person. It is a cholinesterase inhibitor which affects the nervous system. (EPA, 1998) |
| 有害性の概要 | Decomposes at room temperature evolving n-Propylmercaptan (flammable)A cholinesterase inhibitor that may have effects on the nervous system causing convulsions and respiratory depressionCan be absorbed through skin and eyes[ICSC] No significant adverse effects besides cholinesterase inhibition observed in sub-chronic animal feeding studies[HSDB] The average of two baseline respective cholinesterase activity determinations three days apart, with no exposures to enzyme inhibiting pesticides for at least 30 days, is recommended for each worker prior to exposure to cholinesterase inhibitors because of large inter-individual differences in published baseline values. To be established at least once a year. Removal from workplace exposures is recommended until the cholinesterase activity returns to within 20% of baseline. [TLVs and BEIs] See 1-Propanethiol. |
| 反応性グループ | Esters, Sulfate Esters, Phosphate Esters, Thiophosphate Esters, and Borate Esters |
| EC 分類 | Symbol: T+, NR: 25-26/27-43-50/53S: (1/2)-27/28-36/37/39-45-60-61 |
| UN 分類 | UN Hazard Class: 6.1UN Pack Group: I |
| Special Reports | USEPA/Office of Pesticide ProgramsInterim Reregistration Eligibility Decision (IRED) for Ethoprop. EPA issues an IRED for a pesticide that is undergoing reregistration, requires a reregistration eligibility decision, and also needs a cumulative assessment under FQPA. The IRED, issued after EPA completes the individual pesticide\'s aggregate risk assessment, may include taking risk reduction measures -- for example, reducing risks to workers or eliminating uses that the registrant no longer wishes to maintain -- to gain the benefits of these changes before the final RED can be issued following the Agency\'s consideration of cumulative risks.[Available from, as of July 24, 2003: http://www.epa.gov/pesticides/reregistration/status.htm] |
| FIFRA 要件 | Tolerances are established for residues of the nematocide and insecticide (O-ethyl S,S-Dipropyl phosphorodithioate) in or on the following raw agricultural commodities: bananabean, limabean, snapcabbagecorn, foddercorn, foragecorn, fresh (including sweet K=CWHR)corn, graincucumberpeanutpeanut, haypineapplepotatosugarcaneand sweet potato.As the federal pesticide law FIFRA directs, EPA is conducting a comprehensive review of older pesticides to consider their health and environmental effects and make decisions about their future use. Under this pesticide reregistration program, EPA examines health and safety data for pesticide active ingredients initially registered before November 1, 1984, and determines whether they are eligible for reregistration. In addition, all pesticides must meet the new safety standard of the Food Quality Protection Act of 1996. Ethoprop is found on List A, which contains most food use pesticides and consists of the 194 chemical cases (or 350 individual active ingredients) for which EPA issued registration standards prior to FIFRA, as amended in 1988. Case No: 0106Pesticide type: insecticide, fungicide, (nematicide)Registration Standard Date: 06/01/88Case Status: OPP is reviewing data from the pesticide's producers regarding its human health and/or environmental effects, or OPP is determining the pesticide's eligibility for reregistration and developing the Reregistration Eligibility Decision (RED) document.Active ingredient (AI): EthopropData Call-in (DCI) Date(s): 09/15/92, 06/08/94, 10/13/95AI Status: The producers of the pesticide has made commitments to conduct the studies and pay the fees required for reregistration, and are meeting those commitments in a timely manner.Classified for restricted use and limited to use by or under the direct supervision of a certified applicator. Formulation: emulsifiable concentrates 40% and greaterUse Pattern: aquatic usesClassification: restrictedCriteria Influencing Restriction: acute dermal toxicity.Classified for restricted use and limited to use by or under the direct supervision of a certified applicator. Formulation: all granular and fertilizer formulationsUse Pattern: all usesClassification: under evaluation.Based on its review, EPA has identified risk mitigation measures that the Agency believes are necessary to address the human health and environmental risks associated with the current use of ethoprop, and various types of additional data that are necessary to confirm these risk mitigation measures. The Agency is now publishing its interim decision on the reregistration eligibility of and risk management decision for the current uses of ethoprop and its associated human health and environmental risks. The reregistration eligibility and tolerance reassessment decisions for ethoprop will be issued once the cumulative risks for all of the OP pesticides are considered. The Agency may need to pursue further risk management measures for ethoprop once cumulative risks are considered. The ...Interim Reregistration Eligibility Decision for Ethoprop, which was approved on September 28, 2001, contains the Agencys decision on the individual chemical ethoprop. |
| Reactivity Profile | Organothiophosphates, such as ETHOPROPHOS, are susceptible to formation of highly toxic and flammable phosphine gas in the presence of strong reducing agents such as hydrides. Partial oxidation by oxidizing agents may result in the release of toxic phosphorus oxides. |
| 消火 | (Non-Specific -- Organophosphorus Pesticide, Liquid, n.o.s.) Stay upwindkeep out of low areas. Move containers from fire area if you can do it without risk. Fight fire from maximum distance. Dike fire control water for later disposaldo not scatter the material. Wear positive pressure breathing apparatus and special protective clothing.(Non-Specific -- Organophosphorus Pesticide, Liquid, n.o.s.) This material may burn but does not ignite readily. For small fires, use dry chemical, carbon dioxide, water spray, or foam. For large fires, use water spray, fog, or foam. (EPA, 1998)Use water spray, dry powder, carbon dioxide, alcohol-resistant foam. In case of fire: keep drums, etc., cool by spraying with water. NO direct contact with water. |
| 応急処置措置 | Fresh air, rest. Artificial respiration may be needed. Refer immediately for medical attention.Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer immediately for medical attention. Wear protective gloves when administering first aid.First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.Rinse mouth. Give a slurry of activated charcoal in water to drink. Refer immediately for medical attention. |
| 応急処置 | Warning: Effects may be delayed up to 12 hours. Caution is advised.Note: Ethoprophos is a cholinesterase inhibitor.Signs and Symptoms of Ethoprophos Exposure: Acute exposure to ethoprophos may produce the following signs and symptoms: sweating, pinpoint pupils, blurred vision, headache, dizziness, profound weakness, muscle spasms, seizures, and coma. Mental confusion and psychosis may occur. Excessive salivation, nausea, vomiting, anorexia, diarrhea, and abdominal pain may also occur. The heart rate may decrease following oral exposure or increase following dermal exposure. Chest pain may be noted. Hypotension (low blood pressure) may be observed, although hypertension (high blood pressure) is not uncommon. Respiratory symptoms include dyspnea (shortness of breath), pulmonary edema, respiratory depression, and respiratory paralysis.Emergency Life-Support Procedures: Acute exposure to ethoprophos exposure may require decontamination and life support for the victims. Emergency personnel should wear protective clothing appropriate to the type and degree of contamination. Air-purifying or supplied-air respiratory equipment should also be worn, as necessary. Rescue vehicles should carry supplies such as plastic sheeting and disposable plastic bags to assist in preventing spread of contamination.Inhalation Exposure:1. Move victims to fresh air. Emergency personnel should avoid self-exposure to ethoprophos.2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer 100% humidified oxygen or other respiratory support.3. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures.4. Transport to a health care facility.Dermal/Eye Exposure:1. Remove victims from exposure. Emergency personnel should avoid self-exposure to ethoprophos.3. Remove contaminated clothing as soon as possible.4. If eye exposure has occurred, eyes must be flushed with lukewarm water for at least 15 minutes.5. Wash exposed skin areas three times with soap and water.6. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures.7. Transport to a health care facility.Ingestion Exposure:1. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer 100% humidified oxygen or other respiratory support.2. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures. |
| 安全保管 | Provision to contain effluent from fire extinguishing. Separated from food and feedstuffs. Store in an area without drain or sewer access. Ventilation along the floor. |
| 暴露管理・個人防護 | Biological Exposure Indices (BEI) [ACGIH] - Acetylcholinesterase activity in red blood cells = 70% of individual's baselineButylcholinesterase activity in serum or plasma = 60% of individual's baselineSample at end of shift[TLVs and BEIs] |
| 消火手順 | If material on fire or involved in fire: Do not extinguish fire unless flow can be stopped. Use water in flooding quantities as fog. Solid streams of water may be ineffective. Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible. Use "alcohol" foam, dry chemical or carbon dioxide. /Organophosphorus pesticides, liquid, flammable, toxicOrganophosphorus pesticides, liquid, toxic/If material on fire or involved in fire: Use water in flooding quantities as fog. Extinguish fire using agent suitable for type of surrounding fire. (Material itself does not burn or burns with difficulty.) /Organophosphorus pesticides, solid, toxic/ |
| 清掃方法 | Environmental considerations: Air spill: Apply water spray or mist to knock down vapors. /Organophosphorus pesticides, liquid, flammable, toxicOrganophosphorus pesticides, liquid, toxicOrganophosphorus pesticides, solid, toxic/Environmental considerations: Water spill: Use natural barriers or oil spill control booms to limit spill travel. Remove trapped material with suction hoses. /Organophosphorus pesticides, liquid, flammable, toxicEnvironmental considerations: Land spill: Dig a pit, pond, lagoon, holding area to contain liquid or solid material. /SRP: If time permits, pits, ponds, lagoons, soak holes, or holding areas should be sealed with an impermeable flexible membrane liner./ Dike surface flow using soil, sand bags, foamed polyurethane, or foamed concrete. Absorb bulk liquid with fly ash, cement powder, or commercial sorbents. /Organophosphorus pesticides, liquid, flammable, toxic |
| 非火災時の漏出対応 | Excerpt from ERG Guide 152 [Substances - Toxic (Combustible)]:ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area. Do not touch damaged containers or spilled material unless wearing appropriate protective clothing. Stop leak if you can do it without risk. Prevent entry into waterways, sewers, basements or confined areas. Cover with plastic sheet to prevent spreading. Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers. DO NOT GET WATER INSIDE CONTAINERS. (ERG, 2024) |
| 処分方法 | SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air qualitypotential migration in soil or watereffects on animal, aquatic, and plant lifeand conformance with environmental and public health regulations. |
| 漏出処分 | Personal protection: complete protective clothing including self-contained breathing apparatus. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations. Do NOT let this chemical enter the environment. |
| Preventive Measures | Do not contaminate water, food, feed by storage or disposal.Avoid contact with skin and eyes and inhalation of fumes and dust.If material not on fire and not involved in fire: Keep sparks, flames, and other sources of ignition away. Keep material out of water sources and sewers. /Organophosphorus pesticides, solid, toxicIf material not on fire and not involved in fire: Keep sparks, flames, and other sources of ignition away. Keep material out of water sources and sewers. Build dikes to contain flow as necessary. Attempt to stop leak if without undue personnel hazard. Use water spray to knock-down vapors. /Organophosphorus pesticides, liquid, toxic/For more Preventive Measures (Complete) data for ETHOPROP (10 total), please visit the HSDB record page. |
| Isolation and Evacuation | Excerpt from ERG Guide 152 [Substances - Toxic (Combustible)]:IMMEDIATE PRECAUTIONARY MEASURE: Isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids.SPILL: Increase the immediate precautionary measure distance, in the downwind direction, as necessary.FIRE: If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directionsalso, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2024) |
| Treatment | If the compound has been ingested, rapid gastric lavage should be performed using 5% sodium bicarbonate. For skin contact, the skin should be washed with soap and water. If the compound has entered the eyes, they should be washed with large quantities of isotonic saline or water. In serious cases, atropine and/or pralidoxime should be administered. Anti-cholinergic drugs work to counteract the effects of excess acetylcholine and reactivate AChE. Atropine can be used as an antidote in conjunction with pralidoxime or other pyridinium oximes (such as trimedoxime or obidoxime), though the use of '-oximes' has been found to be of no benefit, or possibly harmful, in at least two meta-analyses. Atropine is a muscarinic antagonist, and thus blocks the action of acetylcholine peripherally. |
| 相互作用 | Because different classes of enzymes may be inhibited, the effects of organophosphorus pesticide poisoning may be complex and potentially at least could involve interactions with drugs as well as with other pesticides or chemicals. Potentiation may also involve solvents or other components of formulated pesticides. Certain drugs such a phenothiazines, antihistamines, CNS depressants, barbiturates, xanthines (theophylline), aminoglycosides and parasympathomimetic agents are to be avoided because of increased toxicity. /Organophosphorus pesticides/ |
| 健康影響 | Acute exposure to cholinesterase inhibitors can cause a cholinergic crisis characterized by severe nausea/vomiting, salivation, sweating, bradycardia, hypotension, collapse, and convulsions. Increasing muscle weakness is a possibility and may result in death if respiratory muscles are involved. Accumulation of ACh at motor nerves causes overstimulation of nicotinic expression at the neuromuscular junction. When this occurs symptoms such as muscle weakness, fatigue, muscle cramps, fasciculation, and paralysis can be seen. When there is an accumulation of ACh at autonomic ganglia this causes overstimulation of nicotinic expression in the sympathetic system. Symptoms associated with this are hypertension, and hypoglycemia. Overstimulation of nicotinic acetylcholine receptors in the central nervous system, due to accumulation of ACh, results in anxiety, headache, convulsions, ataxia, depression of respiration and circulation, tremor, general weakness, and potentially coma. When there is expression of muscarinic overstimulation due to excess acetylcholine at muscarinic acetylcholine receptors symptoms of visual disturbances, tightness in chest, wheezing due to bronchoconstriction, increased bronchial secretions, increased salivation, lacrimation, sweating, peristalsis, and urination can occur. Certain reproductive effects in fertility, growth, and development for males and females have been linked specifically to organophosphate pesticide exposure. Most of the research on reproductive effects has been conducted on farmers working with pesticides and insecticdes in rural areas. In females menstrual cycle disturbances, longer pregnancies, spontaneous abortions, stillbirths, and some developmental effects in offspring have been linked to organophosphate pesticide exposure. Prenatal exposure has been linked to impaired fetal growth and development. Neurotoxic effects have also been linked to poisoning with OP pesticides causing four neurotoxic effects in humans: cholinergi |
| 生態毒性値 | LC50 Colinis virginianus (Bobwhite) 33 ppm in 5 day diet (95% confidence limit 27-40 ppm), age 14 days /technical material, 95.8%/LC50 Coturnix japonica (Japanese quail) 100 ppm in 5 day diet (95% confidence limit 85-117 ppm), age 14 days /technical material, 95.8%/LC50 Phasianus colchicus (Ring-necked pheasant) 118 ppm in 5 day diet (95% confidence limit 103-134 ppm), age 10 days /technical material, 95.8%/LC50 Anas platyrhynchos (Mallard duck, /5 day old/) 287 ppm in 5 day diet (95% confidence limit 215-382 ppm), age 5 days /technical material, 95.8%/For more Ecotoxicity Values (Complete) data for ETHOPROP (27 total), please visit the HSDB record page. |
| 環境中動態 | TERRESTRIAL FATE: Based on a classification scheme(1), Koc values in the range of 70-120(2-4), indicate that ethoprop is expected to have high mobility in soil(SRC). Volatilization of ethoprop from moist soil surfaces is not expected to be an important fate process(SRC), given a Henry's Law constant of 1.62X10-7 atm-cu m/mole(SRC), derived from ethoprop's vapor pressure, 0.00038 mm Hg(2) and water solubility, 750 mg/l(2). Ethoprop is not expected to volatilize from dry soil surfaces(SRC) based upon its vapor pressure(2). However, under laboratory conditions, volatilization of ethoprop residue after 12 hours was reported as 1.4-3.6, 2.3-4.5, and 6.5-20.2% from sandy loam soil with 1, 10 and 20 % moisture levels, respectively(7). The US Department of Agriculture's Pesticide Properties Database lists a soil half-life of 25 days for ethoprop(2), but half-lives may range from 3-56 days(4). Due to microbial adaptation, ethoprop degrades more rapidly in soils that have had prior exposure to ethoprop(5,6). Half-lives for photolysis of ethoprop in soil in the sunlight and shade were 4.7 and 12.3 days, respectively(7).AQUATIC FATE: Based on a classification scheme(1), Koc values ranging from 70-120(2-3), indicate that ethoprop is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is not expected(4) based upon a Henry's Law constant of 1.62X10-7 atm-cu m/mole(SRC), derived from a vapor pressure of 0.00038 mm Hg(2) and water solubility 750 mg/l(2). According to a classification scheme(5), BCFs ranging from 4-17(6) suggest the potential for bioconcentration in aquatic organisms is low(SRC). Ethoprop is very stable in neutral and weakly acidic media, but is rapidly hydrolyzed in alkaline media(7). The major degradation pathway for ethoprop under both aerobic and anaerobic conditions is hydrolysis to O-ethyl-S-propyl-phosphorothioic acid(8). The hydrolytic half-lives of ethoprop in distilled, river, brackish and open sea water were 25, 133, 65, and 81 days, respectively(9). Half-lives of 75 and 90 days have been found in sand sediment/water and silt loam sediment/water systems(10).ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), ethoprop, which has a vapor pressure of 0.00038 mm Hg at 20-25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase ethoprop is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC)the half-life for this reaction in air is estimated to be 5.6 hours(SRC), calculated from its rate constant of 6.9X10-11 cu cm/molecule-sec at 25 °C(SRC), that was derived using a structure estimation method(3). While ethoprop was found to undergo photolysis on soil(4), no data were found regarding photolysis by sunlight in air(SRC). |
| 食品調査値 | In a summary of pesticide residue findings of the US Food and Drug Admin's regulatory monitoring of domestic foods which may be eaten by infants/children for fiscal years 1985-1991, ethoprop was detected (concn of 0.14 ppm) in 1 of 2464 apple samples(1). In a US monitoring survey of 6970 produce samples (fruits and vegetables) collected between 1989 and 1991, ethoprop was not detected in any sample at a detection limit of 0.05 ppm(2). In 1989 monitoring conducted by the California Dept of Food and Agric, ethoprop was not detected (detection limit not reported) in any cabbage (1 sample) or potato (10 samples) samples(3). Ethoprop was detected in the ethyl acetate and dichloromethane extracts of brown rice, potato, cabbage, lettuce, carrot, cucumber, apple, strawberry, and banana obtain from a local retail store in Japan(4). Ethoprop was found in foods in an 1994 US regulatory monitoring study(5). |
| 有害作用 | Occupational hepatotoxin - Secondary hepatotoxins: the potential for toxic effect in the occupational setting is based on cases of poisoning by human ingestion or animal experimentation.Other Poison - Organophosphate |
| 暴露経路 | The substance can be absorbed into the body in hazardous amounts by inhalation, through the skin, through the eyes and by ingestion.Oral (L1655)inhalation (L1655)dermal (L1655) |
| Milk Concentrations | Many of the organophosphorus insecticides are excreted in the milk ... /Organophosphorus insecticides/ |
| 毒性の概要 | Ethoprop is a cholinesterase or acetylcholinesterase (AChE) inhibitor. A cholinesterase inhibitor (or 'anticholinesterase') suppresses the action of acetylcholinesterase. Because of its essential function, chemicals that interfere with the action of acetylcholinesterase are potent neurotoxins, causing excessive salivation and eye-watering in low doses, followed by muscle spasms and ultimately death. Nerve gases and many substances used in insecticides have been shown to act by binding a serine in the active site of acetylcholine esterase, inhibiting the enzyme completely. Acetylcholine esterase breaks down the neurotransmitter acetylcholine, which is released at nerve and muscle junctions, in order to allow the muscle or organ to relax. The result of acetylcholine esterase inhibition is that acetylcholine builds up and continues to act so that any nerve impulses are continually transmitted and muscle contractions do not stop. Among the most common acetylcholinesterase inhibitors are phosphorus-based compounds, which are designed to bind to the active site of the enzyme. The structural requirements are a phosphorus atom bearing two lipophilic groups, a leaving group (such as a halide or thiocyanate), and a terminal oxygen. |
| 生態毒性抜粋 | /BIRDS and MAMMALS/ In a reproduction study, the LOEC for Northern bobwhite quail (Colinus virginianus) was 7.5 ppm based on reductions in viable and live embryos, eggs set of eggs laid, and female body weights. /96.8% ai/ /from table//BIRDS and MAMMALS/ In a reproduction study, the LOEC for Mallard duck (Anas platyrhynchos) was 40 ppm based on reductions in eggs laid, eggs set, viable and live 3 wk embryos. /96.8% ai/ /from table//AQUATIC SPECIES/ In a freshwater fish early life-stage toxicity study using Fathead minnow (Pimephales promelus) under flow-through conditions, the NOEC was 0.024 ppm, and the LOEC was 0.054 ppm based on affected larval growth. /Technical ethoprop/ /from table//AQUATIC SPECIES/ The data indicate that ethoprop /(96.5-96.8% ai)/ significantly reduced growth and reproduction /of Waterflea (Daphnia magna), a freshwater invertebrate,/ at concentrations greater than 0.8 and 2.4 ppb, respectively.For more Ecotoxicity Excerpts (Complete) data for ETHOPROP (7 total), please visit the HSDB record page. |
| Plant Concentrations | BEAN & CORN PLANTS WERE GROWN IN SOIL TREATED WITH LABELED MOCAP. ONLY SMALL FRACTION OF LABELED MOCAP WAS TAKEN UP FROM SOIL... MOST OF THE RADIOACTIVITY REMAINED IN THE SOIL.Ethoprop has been detected in a variety of plants that were seeded in soil treated with ethoprop several days to several weeks before seeding(1-3)residues in plants were generally higher with higher rates of ethoprop application(1-3)residues of ethoprop in various plants were as follows: whole onion (0.12-1.34 ppm)(1), radishes (0.12-0.66 ppm)(1), carrots (0.14-0.81 ppm)(1)eggplant (0.027-0.086 ppm)(1)carrots (0.06-0.78 ppm)(2)peas (0.01-2.12 ppm)(2)lima beans (0.02-4.16 ppm)(2)radishes (0.01-0.14 ppm)(2)string beans (0.01-0.11 ppm)(2)turnips (0.01-0.15 ppm)(2)turnip roots (<0.005-0.018 ppm)(3)onions (<0.005-0.068 ppm)(3)radishes (0.005-0.345ppm)(3). |
| CERCLA 報告数量 | Releases of CERCLA hazardous substances are subject to the release reporting requirement of CERCLA section 103, codified at 40 CFR part 302, in addition to the requirements of 40 CFR part 355. Ethoprophos is an extremely hazardous substance (EHS) subject to reporting requirements when stored in amounts in excess of its threshold planning quantity (TPQ) of 1,000 lbs. |
| 州飲料水ガイドライン | (FL) FLORIDA 0.7 ug/l |
| 水環境危害等級（WGK） | 3 |
| RTECS 番号 | TE4025000 |
| 輸送番号（UN） | UN 2810 |
| 毒性 | LC50 (96-hour) for rainbow trout 13.8 mg/L, bluegill sunfish 2.1 mg/L and goldfish 13.6 mg/L (Hartley and Kidd, 1987)acute oral LD50 for rats 262 mg/kg (Hartley and Kidd, 1987), 34 mg/kg (RTECS, 1985). |
| PRTR法 | 1-13 |
| 税関コード | 29309090 |
| 危険文句（R） | 25-26/27-43-50/53 |
| 安衛法 | 57,57-2 |
| 消防法 | 危-4-3-III |
| 危険表示 | T+N,N,T+ |
| 安全措置（S） | 27-28-36/37/39-45-60-61-27/28 |
| 危険等級 | 6.1(a)Acute Tox. 1 DermalAcute Tox. 1 InhalationAcute Tox. 2 OralAquatic Acute 1Aquatic Chronic 1Skin Sens. 1 |
| 包装等級 | II |
| 毒劇物取締法 | II |
| 貯蔵分類 | 6.1A - Combustible, acute toxic Cat. 1 and 2very toxic hazardous materials |
| 有害物質データ | 13194-48-4(Hazardous Substances Data) |
用途
説明
Introduced in the 1960s, ethoprop is a nonsystemic insecticide/nematicide. The mobility of ethoprop in soil and its half-life are strongly dependent on soil organic matter (21). It is not known to be carcinogenic and is available as granules or emulsifiable concentrates.
使用
Ethoprophos is an organophosphate non-systemic nematicide and soil insecticide. Ethoprophos is an acetylcholinesterase (AChE) inhibitor.
一般的な説明
Ethorop is one of a family of organophosphorus pesticides. Mocap is combustible though Mocap may require some effort to ignite. Mocap is very toxic by skin absorption and inhalation. Mocap may or may not be water soluble.