化工社化工社 化学情報印刷レポート · 研究参考用
エチレンジアミン (無水)
エチレンジアミン (無水) · エタン-1,2-ジアミン · 1,2-エタンジアミン · 1,2-ジアミノエタン · 2-アミノエチルアミン · エチレンジアミン · エチレンジアミン(無水) · エチレンジアミン,無水
識別子と物理属性
| CAS No. | 107-15-3 |
|---|---|
| 分子式 | C2H8N2 |
| 平均分子量 | 60.1 g/mol |
| 単同位体質量 | 60.06874826 g/mol |
| SMILES | NCCN |
| InChIKey | PIICEJLVQHRZGT-UHFFFAOYSA-N |
| PubChem CID | 3301 |
| ChEMBL | CHEMBL816 |
| ChEBI | CHEBI:30347 |
| EC No. | 203-468-6 |
| DTXSID | DTXSID5021881 |
| 現地名 | エチレンジアミン (無水) |
化学・物理的性質
| XLogP | -2 |
|---|---|
| 極性表面積 | 52 |
| 水素結合供与体数 | 2 |
| 水素結合受容体数 | 2 |
| 回転可能結合数 | 1 |
| 重原子数 | 4 |
| 形式電荷 | 0 |
| 複雑度 | 6 |
| 物質分類 | Nitrogen Compounds -> Amines, AliphaticCorrosives |
| 医薬品 | Pharmaceuticals -> Listed in ZINC15 |
| pH | 11.9 @ 25 °C (25% soln)12.2 (100g/l, H2O, 20℃) |
| SpringerMaterials Properties | 15N nuclear magnetic resonance spectrum |
| 農薬 | Pesticide -> EPA IRIS |
| LogP（分配係数） | log Kow = -2.04 @ pH 13-1.2 |
| 臭い | Ammonia-like強いアンモニア臭アンモニアのようなマイルドなアンモニア臭。 |
| 食品添加物 | TRACER -> FDA Substance added to food |
| 密度 | 0.898 at 77 °F (EPA, 1998) - Less dense than waterwill float0.898 @ 25 °C/4 °CSaturated liquid density: 56.650 lb/cu ftliquid heat capacity: 0.694 Btu/lb-Fsaturated vapor pressure: 0.216 lb/sq insaturated vapor density: 0.00228 lb/cu ft (all at 70 °F)Relative density (water = 1): 0.90.911.46 @ 20°C0.899 g/mL at 25 °C (lit.) |
| Viscosity | 0.0154 cP @ 25 °C0.0154 cP at 25 °C |
| Color/Form | Water-white liquidColorless, viscous liquid ... [Note: A solid below 47 degrees F]. |
| 溶解度 | greater than or equal to 100 mg/mL at 63 °F (NTP, 1992)Crystalssublimes without meltingfreely sol in waterpractically insol in alc /Dihydrochloride/Sol in benzene unless insufficiently driedslightly sol in etherSOL IN ALL PROPORTIONS IN ETHYL ALCOHOLVERY SOL IN WATERWater solubility = 1X10+6 mg/lMiscible with water, oxygenated and aromatic solventsエタノール: 可溶(点灯)混和性 |
| 融点 | 8.5 °C (lit.) |
| 沸点 | 118 °C (lit.) |
| 蒸気密度 | 2.07 (vs air) |
| 蒸気圧 | 10 mm Hg ( 20 °C) |
| 屈折率 | n20/D 1.4565(lit.) |
| 引火点 | 93 °F |
| 貯蔵条件 | Flammables area |
| pKa（酸解離定数） | 10.712(at 0℃) |
| 外観・状態 | 液体、空気中で発煙 |
| 比重 | 0.899 |
| 色 | 無色～淡黄色 |
| 爆発限界 | 2-17%(V) |
| 比熱容量 | Cp(liquid): 2.87 J/(g·K), at 25℃ |
| Merck | 14,3795 |
| BRN | 605263 |
| ヘンリー定数 | 1.69(x 10-9 atmm3/mol) at 25 °C (Westheimer and Ingraham, 1956) |
| 誘電率 | 16.0(18℃) |
| 主な用途 | 洗浄剤化粧品環境食品および飲料パーソナルケア |
| InChI | 1S/C2H8N2/c3-1-2-4/h1-4H2 |
| InChIKey | PIICEJLVQHRZGT-UHFFFAOYSA-N |
| SMILES | NCCN |
| LogP（分配係数） | -1.6 at 20℃ |
| CAS データベース | 107-15-3(CAS DataBase Reference) |
| NISTの化学物質情報 | Ethylenediamine(107-15-3) |
| EPAの化学物質情報 | Ethylenediamine (107-15-3) |
化学的特性
Ethylenediamine, a polyamine, is a strongly alkaline, colorless, clear, thick liquid. Ammonia odor. A solid below 8.5℃. The Odor Threshold is 1.0 ppm
安全性と法規制
| GHS 分類 | DangerH226: Flammable liquid and vapor [Warning Flammable liquids]P210, P233, P240, P241, P242, P243, P260, P261, P264, P270, P271, P272, P280, P284, P301+P317, P301+P330+P331, P302+P352, P302+P361+P354, P303+P361+P353, P304+P340, P305+P354+P338, P316, P317, P321, P330, P333+P317, P342+P316, P362+P364, P363, P370+P378, P403, P403+P235, P405, and P501 (click each P-code to see the statement)This chemical does not meet GHS hazard criteria for < 0.1% (1 of 2078) of reports.H226 (> 99.9%): Flammable liquid and vapor [Warning Flammable liquids] |
|---|---|
| 規制情報 | Chemical: 1,2-EthanediamineHazard Traits - Respiratory ToxicityCommission Regulation No 844/20121,2-Ethanediamine is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of 1,2-Ethanediamine are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)Status: Active Update: 02-03-2023 https://echa.europa.eu/registration-dossier/-/registered-dossier/15765Substance: Ethylenediamine |
| その他の安全情報 | IMAP assessments - 1,2-Ethanediamine: Environment tier I assessment |
| 輸送ラベル（DOT） | Corrosive Flammable Liquid |
| 火災危険 | Burning rate: 2.2 mm/minute. When exposed to heat or flame, the material has a moderate fire potential. The material can react readily with oxidizing materials. Containers may explode in heat of fire. Material emits nitrogen oxides when burned. Avoid carbon disulfide, silver perchlorate, imines, oxidizing materials. Stable. Hazardous polymerization may not occur. (EPA, 1998)· Flammable/combustible material.Flammable. Gives off irritating or toxic fumes (or gases) in a fire. Above 34 °C explosive vapour/air mixtures may be formed. |
| 火災の可能性 | FLAMMABLE LIQUID WHEN EXPOSED TO HEAT, FLAME OR OXIDIZERS.Contact with ... chlorinated organic cmpd may cause fires ... . |
| 健康有害性 | Vapor inhalations at a concentration of 200 ppm for 5 to 10 minutes will lead to nasal irritation and produce a tingling sensation. Inhalation at concentrations of 400 ppm or greater leads to severe nasal irritation. Respiratory irritation may result. Many individuals are hypersensitive to ethylenediamine exposuretherefore, safe threshold limits are difficult to set. (EPA, 1998)· May cause toxic effects if inhaled or ingested. |
| 有害性の概要 | Liquid causes second degree burns after contact for a few minutes[CHRIS] Corrosive to skin[Quick CPC] Ethylenediamine is used in topical creams and suppositories, e.g., nystatin cream and aminophylline suppositories. Allergic contact dermatitis has been reported in a pharmacist and in healthcare workers. [Marks, p. 85-7] Allergic contact dermatitis in healthcare workers reported after exposure to intravenous aminophylline preparations containing ethylenediamine[Kanerva, p. 1520] Occupational asthma reported in shellac handler and photographer[Malo] Can cause pulmonary edema after an acute inhalation exposure[ICSC] Danger of skin and airway sensitization[MAK] Humans complain of nasal irritation after inhaling concentrations of 200 ppm for 5-10 minutes. [CAMEO] A lachrymator[CHEMINFO] |
| 輸送番号・ガイド（DOT） | 1604 132 |
| FDA 要件 | Ethylenediamine is an indirect food additive for use only as a component of adhesives. |
| 反応性グループ | Amines, Phosphines, and Pyridines |
| EC 分類 | Symbol: CR: 10-21/22-34-42/43S: (1/2)-23-26-36/37/39-45 |
| UN 分類 | UN Hazard Class: 8UN Subsidiary Risks: 3UN Pack Group: II |
| 消火 | Wear full protective clothing including gloves and boots. If necessary to enter closed area, wear full-faced gas masks with self-contained breathing apparatus. Use water spray, dry chemical, alcohol foam, or carbon dioxide. Do not use water in case of drum or tank fires. If a leak or spill has not ignited, use water spray to reduce the vapors and dilute spills to nonflammable mixtures. Use water to keep fire-exposed containers cool. (EPA, 1998)Use water spray, powder, alcohol-resistant foam, carbon dioxide. In case of fire: keep drums, etc., cool by spraying with water. |
| 応急処置措置 | Fresh air, rest. Refer immediately for medical attention.Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer immediately for medical attention.First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.Rinse mouth. Do NOT induce vomiting. Give one or two glasses of water to drink. Refer immediately for medical attention. |
| 漏出応急措置 | · CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.· ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area. |
| 応急処置 | Signs and Symptoms of Acute Ethylenediamine Exposure: Acute exposure to ethylenediamine may result in cough, difficulty in breathing, irritation of the lungs, and pneumonia. Nausea, vomiting, and diarrhea are often seen. Contact with ethylenediamine may result in redness, pain, irritation, and burns.General First Aid:(General first aid procedures) |
| 安全保管 | Fireproof. Separated from strong oxidants, acids, chlorinated organic compounds and food and feedstuffs. Cool. Well closed. Store only in original container. |
| 暴露管理・個人防護 | · Wear positive pressure self-contained breathing apparatus (SCBA). |
| 消火手順 | Use water spray, dry chem, "alcohol resistant" foam, or carbon dioxide. Use water spray to keep fire-exposed containers cool. Solid streams may be ineffective and spread material.Do not use water in case of drum or tank fires. |
| 保管条件 | Outside or detached storage is preferred. Avoid oxidizing materials, acids, and sources of halogens. Store in a cool, dry, well-ventilated location. |
| 清掃方法 | 1. Remove all ignition sources. 2. Ventilate area of spill or leak. 3. If in the liq form, absorb on paper towels. Evaporate in a safe place (such as a fume hood). Allow sufficient time for evaporating vapors to completely clear the hood ductwork. Burn the paper in a suitable location away from combustible materials. Large quantities can be collected and atomized in a suitable combustion chamber equipped with an appropriate effluent gas cleaning device. ... 4. If in the solid form, collect, allow to melt, and dispose of the liq as above.Overspread /spill with/ sufficient sodium bisulfate and sprinkle water. |
| 非火災時の漏出対応 | Excerpt from ERG Guide 132 [Flammable Liquids - Corrosive]: |
| 処分方法 | SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.Ethylenediamine may be disposed of by atomizing in a suitable combustion chamber equipped with an appropriate effluent gas cleaning device.Catalytic /destruction/ of waste gases from ethylenediamine production is described.Removal of ethylenediamine from wastewater using ion exchange is described. |
| 漏出処分 | Remove all ignition sources. Personal protection: complete protective clothing including self-contained breathing apparatus. Ventilation. Collect leaking and spilled liquid in covered containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations. Collect the spilled substance into containers. The container should be made of the same material as the original container. |
| 相互作用 | Ethylenediamine (EDA) (31.6-1000 mg/kg, ip) inhibited the convulsive effects of pentylenetetrazol (100 mg/kg, ip) in mice. EDA (100-1000 mg/kg, ip) incr the convulsion threshold to the iv infusion of 3 convulsants in the order pentylenetetrazol > bicuculline > strychnine.A 37-yr-old pt sensitized to ethylenediamine by topical use of a steroid cream for scaly rash, developed an itchy morbilliform rash affecting the whole body following piperazine citrate therapy for threadworms. |
| 標的器官 | Skin, respiratory system, liver, kidneys |
| 生態毒性値 | LC50 Pimephales promelas (fathead minnow) 115.7 mg/l/96 hr @ 22 °C (95% confidence limit 98.6-131.6 mg/l) /Static bioassay/TLM: ORYZIAS LATIPES 1000 MG/L/24 HR /CONDITIONS OF BIOASSAY NOT SPECIFIED/Toxicity Threshold (Cell Multiplication Inhibition Test) Uronema parduczi Chatton-Lwoff (protozoa) 52 mg/l /Conditions of bioassay not specified/Toxicity Threshold (Cell Multiplication Inhibition Test) Scenedesmus quadricauda (green algae) 0.85 mg/l /Conditions of bioassay not specified/For more Ecotoxicity Values (Complete) data for ETHYLENEDIAMINE (9 total), please visit the HSDB record page. |
| 環境中動態 | TERRESTRIAL FATE: Based on a classification scheme(1), an average Koc value of 4766(2) indicates that ethylenediamine is expected to have slight mobility in soil(SRC). Volatilization of ethylenediamine from moist soil surfaces is not expected to be an important fate process(SRC) given a Henry's Law constant of 1.73X10-9 atm-cu m/mole(3). The potential for volatilization of ethylenediamine from dry soil surfaces may exist based upon a vapor pressure of 12.1 mm Hg(4). However, adsorption to soil may attenuate volatilization(SRC). Based on screening studies(5-7), biodegradation is expected to be the most important degradation process for this compound but no experimental rates in soil are available. Ethylenediamine may also form stable complexes with metal ions(8) in soil, but again, experimental data are lacking(SRC).AQUATIC FATE: Based on a classification scheme(1), an average Koc value of 4766(2) indicates that ethylenediamine is expected to adsorb to suspended solids and sediment in water(SRC). Volatilization from water surfaces is not expected(3) based upon a Henry's Law constant of 1.73X10-9 atm-cu m/mole(4). As ethylenediamine has two primary amine groups, at the pH range found in most environmental waters, it is expected to be partially protonatedthe dissociated form will not volatilize. According to a classification scheme(5), an estimated BCF of less than 1(SRC), from its log Kow(6) and a regression-derived equation(7), suggests the potential for bioconcentration in aquatic organisms is low. Based on screening studies(8-10), biodegradation is expected to be the most important degradation process for this compound but no experimental rates in water are available. Complexation of ethylenediamine with transition metals(11) in the water or reaction with humic materials(12) is possible(SRC).ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), ethylenediamine, which has a vapor pressure of 12.1 mm Hg at 25 °C(2), is expected to exist solely as a vapor. Vapor-phase ethylenediamine is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC)the half-life for this reaction in air is estimated to be 6 hours(SRC), calculated from its rate constant of 6.3x10-11 cu cm/molecule-sec at 25 °C(3) using a structure estimation method(3). As ethylenediamine is miscible in water(4), washout by rain will also be an important removal process(SRC). |
| 食品調査値 | ... Amines from decomposing fish ... /Amines/ |
| 有害作用 | Dermatotoxin - Skin burns. |
| 暴露経路 | The substance can be absorbed into the body by inhalation, through the skin and by ingestion.inhalation, skin absorption, ingestion, skin and/or eye contact |
| Signs and Symptoms | Cough. Sore throat. Shortness of breath. Burning sensation. Wheezing. Shortness of breath.Redness. Pain. Burning sensation. Skin burns.Redness. Pain. Blurred vision. Severe burns.Burns in mouth and throat. Sore throat. Burning sensation. Abdominal pain. Shock or collapse.irritation nose, respiratory systemsensitization dermatitisasthmaliver, kidney damage |
| EPA IRIS Information | Ethylene diamine |
| Medical Surveillance | ... A complete history and physical exam /is required/ ... to detect existing conditions that might place the exposed employee at increased risk, and to establish a baseline for future health monitoring. Persons with a history of asthma, allergies, or unknown sensitization to ethylenediamine would be expected to be at incr risk from exposure. Exam of the resp system, liver, and kidneys should be stressed. The skin should be examined for evidence of chronic disorders. ... Should be repeated on an annual basis. |
| Soil Adsorption/Mobility | Ethylenediamine has two primary amine groups and at the pH range found in most soils it is expected to be partially protonated given a pKa1 of 10.7 and a pKa2 of 7.6(1). An average Koc of 4766 (range=2071 to 6160) was measured for ethylenediamine in six different soilsfive were from the vadose zone and one from an aquifer (saturated zone)(2). pH values ranged from 6.0 to 9.6 and the fraction of organic carbon from 0.0024 to 0.0391 for this group of soils. Soils with increased cation exchange capacity and organic content had greater affinity for ethylenediamine(2). |
| TSCA Test Submissions | Ethylenediamine (CAS # 107-15-3) was evaluated for acute oral toxicity in groups of Fischer 344 rats (5/sex/group) administered single oral doses of 200, 400, 800, 1200, and 1800 mg/kg bodyweight as a monohydrochloride or dichlorohydride salt in water. Mortality was attributed to treatment at doses of 1800 mg/kg (9/10) and 1200 mg/kg (2/10)An LD50 was not calculated. Clinical signs observed in the 1200 mg/kg group included emaciation, bluish extremities and diarrhea. Upon necropsy, no gross pathology was observed. |
| 大気基準 | This action promulgates standards of performance for equipment leaks of Volatile Organic Compounds (VOC) in the Synthetic Organic Chemical Manufacturing Industry (SOCMI). The intended effect of these standards is to require all newly constructed, modified, and reconstructed SOCMI process units to use the best demonstrated system of continuous emission reduction for equipment leaks of VOC, considering costs, non air quality health and environmental impact and energy requirements. Ethylenediamine is produced, as an intermediate or a final product, by process units covered under this subpart. |
| CERCLA 報告数量 | Releases of CERCLA hazardous substances are subject to the release reporting requirement of CERCLA section 103, codified at 40 CFR part 302, in addition to the requirements of 40 CFR part 355. Ethylenediamine is an extremely hazardous substance (EHS) subject to reporting requirements when stored in amounts in excess of its threshold planning quantity (TPQ) of 10,000 lbs.Persons in charge of vessels or facilities are required to notify the National Response Center (NRC) immediately, when there is a release of this designated hazardous substance, in an amount equal to or greater than its reportable quantity of 5000 lb or 2270 kg. The toll free number of the NRC is (800) 424-8802In the Washington D.C. metropolitan area (202) 426-2675. The rule for determining when notification is required is stated in 40 CFR 302.4 (section IV. D.3.b). |
| 清浄水法要件 | Ethylenediamine is designated as a hazardous substance under section 311(b)(2)(A) of the Federal Water Pollution Control Act and further regulated by the Clean Water Act Amendments of 1977 and 1978. These regulations apply to discharges of this substance. This designation includes any isomers and hydrates, as well as any solutions and mixtures containing this substance. |
| DHS Chemicals of Interest (COI) | Ethylenediamine120000Toxic chemical that can be released at a facility. |
| 州飲料水ガイドライン | (FL) FLORIDA 10,000 ug/l |
| F | 10-34 |
| 職業暴露区分（OEB） | A |
| 職業暴露限界（OEL） | TWA: 10 ppm (25 mg/m3) |
| 水環境危害等級（WGK） | 2 |
| 生命健康即時危険濃度 | 1,000 ppm |
| TSCA 収載状態 | TSCA listed |
| RTECS 番号 | KH8575000 |
| 輸送番号（UN） | UN 1604 |
| 毒性 | LD50 orally in rats: 1.16 g/kg (Smyth) |
| PRTR法 | 第一種指定化学物質 |
| 税関コード | 29212110 |
| 危険文句（R） | 10-21/22-34-42/43 |
| 化審法 | (2)-150 |
| 安衛法 | 57,57-2 |
| 消防法 | 危険物第4類第二石油類(水溶性) |
| 危険表示 | C |
| 安全措置（S） | 23-26-36/37/39-45 |
| 危険等級 | 8Acute Tox. 3 DermalAcute Tox. 4 InhalationAcute Tox. 4 OralAquatic Chronic 3Eye Dam. 1Flam. Liq. 3Resp. Sens. 1BSkin Corr. 1BSkin Sens. 1B |
| 包装等級 | II |
| 毒劇物取締法 | 劇物 |
| 自然発火温度 | 716 °F |
| 環境リスク評価 | エチレンジアミン(107-15-3) |
| 貯蔵分類 | 3 - Flammable liquids |
| 有害物質データ | 107-15-3(Hazardous Substances Data) |
| 発がん性評価について | EPA D |
用途
解説
エチレンジアミン．工業的には，1,2-ジクロロエタンとアンモニアからつくられる．アンモニア臭をもつ無色の液体．融点10.8 ℃，沸点117 ℃．d2020 0.900．n20D 1.457．強塩基性で，亜硝酸によりエチレンオキシドになる．代表的なキレート試薬で，ほとんどの金属に二座配位して錯体を形成する．エチレンジアミン四酢酸(EDTA)として，また，殺菌剤，分析試薬，医薬品として用いられる．LD50 1.16 g/kg(ネズミ，経口)．
用途
キレート剤?エポキシ樹脂硬化剤?殺菌剤?繊維加工剤 (防しわ剤,染料固着剤)?可塑剤?ゴム薬品合成原料;キレート化剤?繊維関係薬品(防しわ剤?界面活性剤?染料固着剤)?イオン交換樹脂?ゴム薬品原料;繊維関係,農薬原料,キレート化剤
説明
Ethylenediamine is used in numerous industrial proces ses as a solvent for casein or albumin, as a stabilizer in rubber latex and as a textile lubricant. It can be found in epoxy-resin hardeners, cooling oils, fungicides, and waxes. Contact dermatitis from ethylenediamine is almost exclusively due to topical medicaments. Occupational contact dermatitis in epoxy-resin systems is rather infrequent. Ethylenediamine can cross react with triethylenetetramine and diethylenetriamine. Ethylenediamine was responsible for sensitization in pharmacists handling aminophylline suppositories, in nurses preparing and administering injectable theophylline, and in a laboratory technician in the manufacture of aminophylline tab lets.
使用
[Note—Edamine is the recommended contraction for the ethylenediamine radical.].
一般的な説明
Ethylenediamine is a linear aliphatic diamine, widely used as a building block in organic synthesis. It readily forms heterocyclic imidazolidine derivatives, because of its bifunctional nature, having two amines. Ethylenediamine is also utilized as a raw material for the synthesis of chelating agents, polymers, agrochemicals and pharmaceutical intermediates.
使用用途
エチレンジアミンは、多くの化合物との反応性が高いため、新たな化学物質をつくる合成原料として使用されています。産業分野での例を挙げると、合成ワックス、除草剤、界面活性剤、乳化剤、湿潤剤、、腐食防止剤、洗剤、繊維表面処理などです。 医療分野の例では、抗ヒスタミン薬など化学的安定化剤として薬剤の合成、アレルギー性皮膚炎の診断を補助するためのアレルギー性上皮性パッチ検査など幅広い用途で使用されます。また、農薬関係では、殺菌剤、殺虫剤、除草剤などにも用いられます。 その他、キレート剤、コーティング剤、接着剤、イオン交換樹脂原料、ゴム薬品なども用途の1つです。
製法・合成法
調製方法
The production of ethylene-1,2-diamine (EDA) is by the catalytic amination of monoethanolamine or the reaction of aqueous ammonia with 1,2-dichloroethane (Spitz 1979). U.S. Production is estimated at greater than 33,000 tons in 1975.
製造方法
エチレンジアミンは、エチレンジクロライドとまたはアンモニア水との反応により生産されます。これらの原料を混合して、加圧下、110℃で加熱し反応させます。 ClCH2CH2Cl + 2NH3 / NH2H2CH2NH2 + 2HCl 反応により得られた生成物は、蒸留塔に送られます。そこで未反応のエチレンジクロライドは分離して反応槽へ戻されます。蒸留塔では40%苛性ソーダを振らせて、生成したアミン塩酸塩及び塩化アンモニアを中和し、遊離する過剰のアンモニアは反応塔に戻され再利用されます。 蒸留塔の底部から回収されるエチレンジアミンおよび食塩水を分離槽へ送り、分離槽で食塩水をエチレンジアミンから分離します。エチレンジアミンは精留塔で常圧、150~180℃で精製されます。残留分は沸点200℃以上のエチレントリアミン、およびポリアミンです。エチレンジアミンとトリアミン以上のポリアミンとの生成比率は2 : 1となります。