エチゾラム
4-(2-クロロフェニル)-2-エチル-9-メチル-6H-チエノ[3,2-f][1,2,4]トリアゾロ[4,3-a][1,4]ジアゼピン · 4-(o-クロロフェニル)-2-エチル-9-メチル-6H-チエノ[3,2-f][1,2,4]トリアゾロ[4,3-a][1,4]ジアゼピン · エチカーム · セデコパン · グペリース · エチセダン · モーズン · パルギン
識別子と物理属性
| CAS No. | 40054-69-1 |
|---|---|
| 分子式 | C17H15ClN4S |
| 平均分子量 | 342.8 g/mol |
| 単同位体質量 | 342.07059516 g/mol |
| SMILES | CCc1cc2c(s1)-n1c(C)nnc1CN=C2c1ccccc1Cl |
| InChIKey | VMZUTJCNQWMAGF-UHFFFAOYSA-N |
| PubChem CID | 3307 |
| ChEMBL | CHEMBL1289779 |
| ChEBI | CHEBI:31583 |
| EC No. | 662-368-4 |
| DTXSID | DTXSID0023030 |
| 現地名 | エチゾラム |
化学・物理的性質
| XLogP | 2.6 |
|---|---|
| 極性表面積 | 71.3 |
| 水素結合供与体数 | 0 |
| 水素結合受容体数 | 4 |
| 回転可能結合数 | 2 |
| 重原子数 | 23 |
| 形式電荷 | 0 |
| 複雑度 | 474 |
| 医薬品 | DEA NFLIS-Drug Category -> BenzodiazepinesDEA Schedule I Controlled Substance -> DepressantsPharmaceuticals -> Synthetic Cannabinoids or Psychoactive CompoundsPharmaceuticals -> Listed in ZINC15 |
| LogP（分配係数） | 2.52 |
| 溶解度 | Practically insolubleDMF: 5 mg/mlDMSO: 5 mg/mlDMSO:PBS(pH7.2) (1:1): 0.5 mg/ml |
| Human Drugs | Breast FeedingLactationMilk, HumanHypnotics and SedativesAnti-Anxiety AgentsBenzodiazepines |
| 融点 | 147-148147-148℃ |
| 沸点 | 264.5°C (rough estimate) |
| 密度 | 1.43 |
| 屈折率 | 1.6100 (estimate) |
| 引火点 | 9°C |
| 貯蔵条件 | -20°C |
| 外観・状態 | A neat solid |
| pKa（酸解離定数） | 2.37±0.40(Predicted) |
| CAS データベース | 40054-69-1 |
安全性と法規制
| GHS 分類 | DangerH315 (60%): Causes skin irritation [Warning Skin corrosion/irritation]P203, P264, P264+P265, P280, P302+P352, P305+P351+P338, P318, P321, P332+P317, P337+P317, P362+P364, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 65 reports by companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. |
|---|---|
| 規制情報 | DEA schedule I controlled substance |
| Hazard Classes and Categories | Skin Irrit. 2 (60%) |
| Treatment | General supportive measures should be employed, along with intravenous fluids, and an adequate airway maintained. Hypotension may be combated by the use of norepinephrine or metaraminol. Dialysis is of limited value. Flumazenil (Anexate) is a competitive benzodiazepine receptor antagonist that can be used as an antidote for benzodiazepine overdose. In particular, flumazenil is very effective at reversing the CNS depression associated with benzodiazepines but is less effective at reversing respiratory depression. Its use, however, is controversial as it has numerous contraindications. It is contraindicated in patients who are on long-term benzodiazepines, those who have ingested a substance that lowers the seizure threshold, or in patients who have tachycardia or a history of seizures. As a general rule, medical observation and supportive care are the mainstay of treatment of benzodiazepine overdose. Although benzodiazepines are absorbed by activated charcoal, gastric decontamination with activated charcoal is not beneficial in pure benzodiazepine overdose as the risk of adverse effects often outweigh any potential benefit from the procedure. It is recommended only if benzodiazepines have been taken in combination with other drugs that may benefit from decontamination. Gastric lavage (stomach pumping) or whole bowel irrigation are also not recommended. |
| 毒性の概要 | Benzodiazepines bind nonspecifically to benzodiazepine receptors BNZ1, which mediates sleep, and BNZ2, which affects affects muscle relaxation, anticonvulsant activity, motor coordination, and memory. As benzodiazepine receptors are thought to be coupled to gamma-aminobutyric acid-A (GABAA) receptors, this enhances the effects of GABA by increasing GABA affinity for the GABA receptor. Binding of the inhibitory neurotransmitter GABA to the site opens the chloride channel, resulting in a hyperpolarized cell membrane that prevents further excitation of the cell. |
| Carcinogen Classification |
用途
解説
C17H15ClN4S(342.85)．5-(2-クロロフェニル)-1,3-ジヒドロ-7-エチル-2H-チエノ[2.3-e][1.4]ジアゼピン-2-チオンに抱水ヒドラジンを作用させ，得られた2-ヒドラジノ体に無水酢酸を作用させ，ついで加熱閉環させると得られる．"白色～微黄白色の結晶性粉末．融点146～149 ℃．クロロホルム，エタノールに易溶，酢酸エチル，ジエチルエーテルに難溶，水に不溶．チエノジアゼピン系精神安定剤．神経症，うつ病，心身症，精神分裂病における不安·緊張·睡眠障害などに処方される．LD50 3619 mg/kg(ラット，経口)．[CAS 40054-69-1]森北出版「化学辞典（第2版）
用途
生化学用試薬、神経作用物質
用途
ベンゾジアゼピン系化合物で す。GABA 受容体に作用し、中枢神経抑制作 用を示します。作用時間は短時間です。
用途
ベンゾジアゼピン系化合物で す。GABA受容体に作用し、中枢神経抑制作 用を示します。作用時間は短時間です。
説明
Etizolam is a potent thienodiazepine anxiolytic closely related to brotizolam. Pharmacologically, however, its profile most resembles that of diazepam.
使用
Etilozam is a a thienodiazepine benzodiazepine derivative, and has amnesic, anxiolytic, anticonvulsant, hypnotic, sedative and skeletal muscle relaxant properties. Etizolam is an anxiolytic related to that of the classic benzodiazepines. Etizolam has effect on monoamine metabolism in brain. Etilozam can be used for the short-term treatment of insomnia, anxiety or panic attacks.