基本情報
- CAS
29560-58-5- 標準SMILES
CCOC(=O)Nc1ccc2c(c1)N(C(=O)CCN1CCOCC1)c1ccccc1S2.Cl- InChIKey
GAQAKFHSULJNAK-UHFFFAOYSA-N- 分子式
- C22H26ClN3O4S
- 平均分子量
- 464 g/mol
- 単同位体質量
- 463.1332552
概要
Moricizine Hydrochloride is the hydrochloride salt form of moricizine, a phenothiazine analog with class I antiarrhythmic activity. Moricizine hydrochloride blocks the rapid flow of sodium ions into the myocardial cell during phase 0 of the action potential. This decreases excitability, slows the impulse conduction through the atrioventricular (AV) node and depresses depolarization.
名称と識別子
- 優先名称
- Ethmozine
- IUPAC
- ethyl N-[10-(3-morpholin-4-ylpropanoyl)phenothiazin-2-yl]carbamate;hydrochloride
- 現地名
- モリシジン·塩酸塩
- 英語名
- Moracizine hydrochloride
- 分子式
- C22H26ClN3O4S
- 分子量
- 463.98
名称と別名
MORICIZINE HYDROCHLORIDE29560-58-5EthmozineMoracizine hydrochlorideMoricizine HClEthmozinEtmozinDTXSID104778671OK3Z1ESPMoricizine hydrochloride (USP)Moricizine hydrochloride [USP]DTXCID1027766
名称をさらに表示
[10-[3-(4-モルホリニル)-1-オキソプロピル]-10H-フェノチアジン-2-イル]カルバミン酸エチル·塩酸塩モリシジン·塩酸塩エトモジンモリシジン塩酸塩en313MORACIZINE HCLMoricizine Hydrochloride (250 mg)Moricizine Hydrochloride (1446950)ethyl10-(3-morpholinopropionyl)phenothiazine-2-carbamatehydrochloride
Ethyl 10-(3-morpholinopropionyl)phenothiazine-2-carbamate hydrochlorideEthyl 10-(beta-N-morpholinylpropionyl)phenothiazine-2-carbamate hydrochlorideCHEBI:60937RefChem:56790Hydrochloride, MoricizineCarbamic Acid,(10-(3-(4-morpholinyl)-1-oxopropyl)-10H-phenothiazin-2-yl)-, Ethyl Ester, MonohydrochlorideMoricizine (Hydrochloride)Ethmosine
データベース識別子
- CAS
29560-58-5
物性
構造計算による物性
- 極性表面積
- 96.4 Ų
- 水素結合供与体数
- 2
- 水素結合受容体数
- 6
- 回転可能結合数
- 6
- 重原子数
- 31
- 形式電荷
- 0
- 複雑度
- 601
実験および物理化学的性質
Human Drugs
FDA approved drugs -> Active ingredient
FDA approved drugs -> Active ingredient
物理化学的性質
- 融点
- 189 ° · 189° (dec)
- 外見
- Solid
- 色
- Off-white to light brown
- 主な用途
- 医薬品（低分子化合物）
- InChI
- 1S/C22H25N3O4S.ClH/c1-2-29-22(27)23-16-7-8-20-18(15-16)25(17-5-3-4-6-19(17)30-20)21(26)9-10-24-11-13-28-14-12-24;/h3-8,15H,2,9-14H2,1H3,(H,23,27);1H
- InChIKey
- GAQAKFHSULJNAK-UHFFFAOYSA-N
- SMILES
- S1c2c(cc(cc2)NC(=O)OCC)N(c4c1cccc4)C(=O)CC[N+H]3CCOCC3.[Cl-]
- EPAの化学物質情報
- Moricizine hydrochloride (29560-58-5)
安全と法規制
安全情報は参考情報です。供給元の安全データシート（SDS）、適用法令、専門家による評価に代わるものではありません。
毒性情報
Drug Induced Liver Injury
Drug Induced Liver Injury Rank (DILIrank 2.0)
Moricizine hydrochloride
Ambiguous-DILI-concern
5
Adverse reactions
DOI:10.1016/j.drudis.2016.02.015
安全データ
- wgk
- WGK 1
- tsca
- TSCA listed
- 毒性
- LD50 in mice, rats (mg/kg): 36, 12 i.v.; in mice (mg/kg): 131 i.p. (Kaverina)
- hs_code
- 2934302700
- Hazard Classifications
- Acute Tox. 4 Oral
- ストレージクラス
- 11 - Combustible Solids
化学と産業
薬理情報
MeSH Pharmacological Classification
Agents used for the treatment or prevention of cardiac arrhythmias. They may affect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers. Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade.
A class of drugs that inhibit the activation of VOLTAGE-GATED SODIUM CHANNELS.
用途と製造
General Manufacturing InformationCarbamic acid, N-[10-[3-(4-morpholinyl)-1-oxopropyl]-10H-phenothiazin-2-yl]-, ethyl ester, hydrochloride (1:1): INACTIVE
応用分野
説明Moricizine hydrochloride is a phenothiazine derivative with antiarrhythmic activity developed by the Soviet Academy of Medical Sciences. It is licensed to Dupont-Sanko in a joint venture. Moricizine hydrochloride is the first drug licensed to a U.S. company by the Soviet Union and was introduced by Dupont in the U.S. in 1990 for specific use in Iife-threatening ventricular arrhythmias. This narrow indication reflects its proarrhythmic potential. The incidence of this adverse reaction, however, is lower than that of other antiarrhythmic agents.
使用Cardiac depressant (anti-arrhythmic).
上流・下流製品情報
上流原料
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