グルタルアルデヒド

グルタルアルデヒド (2426%水溶液) · グルタルアルデヒド (約50%水溶液, 約5.6mol/L) · グルタロール · グルタルジアルデヒド · ステリゾール · ステリハイドL · サイデックスプラス28 · グルトハイドスコープ

https://huagongshe.com/ja/chemical/3485

識別子と物理属性

CAS No.	111-30-8
分子式	C5H8O2
平均分子量	100.12 g/mol
単同位体質量	100.05242949 g/mol
SMILES	O=CCCCC=O
InChIKey	SXRSQZLOMIGNAQ-UHFFFAOYSA-N
PubChem CID	3485
ChEMBL	CHEMBL1235482
ChEBI	CHEBI:64276
EC No.	203-856-5
DTXSID	DTXSID6025355
現地名	グルタルアルデヒド

化学・物理的性質

XLogP	-0.5
極性表面積	34.1
水素結合供与体数	0
水素結合受容体数	2
回転可能結合数	4
重原子数	7
形式電荷	0
複雑度	51
pH	Mildly acidic (50% solution)>3.0 (H2O, 20°C)
LogP（分配係数）	log Kow = -0.33-0.22
臭い	Pungent odorSweetish刺激的なアルデヒド臭
密度	1.062 to 1.124 at 68 °F (USCG, 1999)0.72Relative density (water = 1): 0.71.33 g/cm³1.100.72 @25 °C1.058 g/mL at 20 °C
Viscosity	12.75 mm²/s at 25 °C
Color/Form	Colorless liquidOil
溶解度	greater than or equal to 100 mg/mL at 72 °F (NTP, 1992)Miscible with waterSoluble in ethanol, benzene, etherMiscible with ethanolSolubility in water: miscibleChloroform (Slightly), DMSO (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)混和性
引火点	>95 °C c.c.100°C
沸点	369 to 372 °F at 760 mmHg (decomposes) (NTP, 1992)187-189 °C (decomposes)Boiling point: 106-108 °C at 50 mm Hg, 71-72 °C at 10 mm Hg188.00 °C. @ 760.00 mm Hg101 °C369-372 °100 °C
Decomposition	When heated to decomposition it emits acrid smoke and irritating fumes.187-189 °C
融点	less than 20 °F (USCG, 1999)Freezing point: -14 °C-33 °C7 °F-15 °C
蒸気密度	3.4 (Air = 1)Relative vapor density (air = 1): 3.5Relative vapor density (air = 1): 1.051.05 (vs air)
蒸気圧	15 mmHg ( 20 °C)
屈折率	n20/D 1.450
貯蔵条件	Store below +30°C.
外観・状態	解決
色	透明～わずかなもや
比重	1.06
由来生物	synthetic
Merck	14,4472
BRN	605390
ヘンリー定数	3.0×102 mol/(m3Pa) at 25℃, Olson (1998)
安定性	Light Sensitive
化粧品成分の機能	香料防腐剤
InChI	1S/C5H8O2/c6-4-2-1-3-5-7/h4-5H,1-3H2
InChIKey	SXRSQZLOMIGNAQ-UHFFFAOYSA-N
SMILES	[H]C(CCCC([H])=O)=O
LogP（分配係数）	-0.180 (est)
CAS データベース	111-30-8(CAS DataBase Reference)
NISTの化学物質情報	Glutaral(111-30-8)
EPAの化学物質情報	Glutaraldehyde (111-30-8)

化学的特性

Glutaraldehyde is a colorless liquid with a pungent odor, which readily changes to a glossy polymer. The Odor Threshold is 0.04 ppm (NY) and 0.2 ppm (NJ). It is miscible in water and organic solvents. Glutaraldehyde may be incompatible with strong oxidizers and strong bases. It should be noted that alkaline solutions containing glutaraldehyde may react with alcohol, ketones, amines, hydrazines, and proteins.

安全性と法規制

GHS 分類	DangerH301: Toxic if swallowed [Danger Acute toxicity, oral]H314: Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]H317: May cause an allergic skin reaction [Warning Sensitization, Skin]H330: Fatal if inhaled [Danger Acute toxicity, inhalation]H334: May cause allergy or asthma symptoms or breathing difficulties if inhaled [Danger Sensitization, respiratory]H335: May cause respiratory irritation [Warning Specific target organ toxicity, single exposureRespiratory tract irritation]H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]H411: Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]P233, P260, P261, P264, P270, P271, P272, P273, P280, P284, P301+P316, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P354+P338, P316, P319, P320, P321, P330, P333+P317, P342+P316, P362+P364, P363, P391, P403, P403+P233, P405, and P501 (click each P-code to see the statement)This chemical does not meet GHS hazard criteria for < 0.1% (1 of 2123) of reports.
規制情報	Chemical: PentanedialSpecific Information Requirement: Obligations to provide information apply. These obligations are:1. If the assessment report about the chemical recommends secondary notification of the chemical in particular circumstances and any of the circumstances occur in relation to the introduction (importation or manufacture) of the chemical by a person, then the person introducing this chemical must tell us in writing within 28 calendar days that the circumstances have occurred.2. A person who introduces this chemical must tell us in writing within 28 calendar days if they become aware of any of the following circumstances, namely, that since the assessment under the Industrial Chemicals (Notification and Assessment) Act 1989:a. the function or use of the chemical has changed, or is likely to change, significantlyb. the amount of the chemical being introduced has increased, or is likely to increase, significantlyc. in the case of a chemical not manufactured, or proposed to be manufactured, in Australia at the time of the assessmentâit has begun to be manufactured in Australiad. the method of manufacture of the chemical in Australia has changed, or is likely to change, in a way that may result in an increased risk of an adverse effect of the chemical on occupational health and safety, public health or the environment

GHS 分類

DangerH301: Toxic if swallowed [Danger Acute toxicity, oral]H314: Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]H317: May cause an allergic skin reaction [Warning Sensitization, Skin]H330: Fatal if inhaled [Danger Acute toxicity, inhalation]H334: May cause allergy or asthma symptoms or breathing difficulties if inhaled [Danger Sensitization, respiratory]H335: May cause respiratory irritation [Warning Specific target organ toxicity, single exposureRespiratory tract irritation]H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]H411: Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]P233, P260, P261, P264, P270, P271, P272, P273, P280, P284, P301+P316, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P354+P338, P316, P319, P320, P321, P330, P333+P317, P342+P316, P362+P364, P363, P391, P403, P403+P233, P405, and P501 (click each P-code to see the statement)This chemical does not meet GHS hazard criteria for < 0.1% (1 of 2123) of reports.

規制情報

Chemical: PentanedialSpecific Information Requirement: Obligations to provide information apply. These obligations are:1. If the assessment report about the chemical recommends secondary notification of the chemical in particular circumstances and any of the circumstances occur in relation to the introduction (importation or manufacture) of the chemical by a person, then the person introducing this chemical must tell us in writing within 28 calendar days that the circumstances have occurred.2. A person who introduces this chemical must tell us in writing within 28 calendar days if they become aware of any of the following circumstances, namely, that since the assessment under the Industrial Chemicals (Notification and Assessment) Act 1989:a. the function or use of the chemical has changed, or is likely to change, significantlyb. the amount of the chemical being introduced has increased, or is likely to increase, significantlyc. in the case of a chemical not manufactured, or proposed to be manufactured, in Australia at the time of the assessmentâit has begun to be manufactured in Australiad. the method of manufacture of the chemical in Australia has changed, or is likely to change, in a way that may result in an increased risk of an adverse effect of the chemical on occupational health and safety, public health or the environment

用途

解説

グルタルアルデヒド (Glutaraldehyde) とは、ジアルデヒド化合物に分類される有機化合物です。分子式はC5H8O2であり、IUPAC命名法に則った名称では1,5-ペンタンジアール (1,5-Pentanedial) と呼ばれます。CAS登録番号は111-30-8です。分子量100.12、融点-14℃、沸点71-72℃であり、常温では無色またはわずかに薄い黄色の液体です。刺激臭があります。水、アルコール、に容易に溶解する物質です。

用途

有機合成原料、殺菌消毒剤、安定剤。

用途

皮なめし、消毒剤

用途

写真用ゼラチンの架橋剤(硬膜剤)、皮革のなめし剤、紙?プラスチックなどへの定着剤、菌?消毒剤。

説明

Glutaraldehyde is a well-known sensitizer among cleaners and health workers. It is also found in X-ray developers products.

使用

Glutaraldehyde (Symbol GTA; glutaric dialdehyde, 1,5-pentanedial, glutaral) is commonly used in the medical industry in cold sterilization and in the X-ray development process. It can also be encountered in the leather industry as a tanning ingredient and in mortuary workers. There are no reports which indicate that glutaraldehyde is a naturally occurring compound. Cidex and Acusol, 2% buffered solutions, use this aldehyde as an active ingredient. Sodium bicarbonate is required to activate the solution, which then has a shelf life of 1–2 weeks. Despite health hazards involved with its use, glutaraldehyde is one of the most effective biocides used. It is particularly effective against bacteria and viruses, including the human immunodeficiency virus.

一般的な説明

Light yellow liquid. Mixes with water.

使用用途

グルタルアルデヒドはの固定液のほか、皮のなめし剤や紙・プラスチックなどへの定着剤、写真用ゼラチンの架橋剤 (硬膜剤) 、レントゲン写真の現像液などに使用されます。アルデヒド基を2つ持っているため固定力が強く、微細構造の形態保持に優れています。しかし、組織内の浸透力が弱いため、通常、組織試料は1mm角の大きさが上限です。更に、約1～2時間程度、4℃で冷却する必要があります。強い殺菌力を有しており、内視鏡や手術器具類などの医療用器具・機器・装置に対して、化学的滅菌・殺菌消毒剤として利用されます。2%グルタルアルデヒド溶液や20%グルタルアルデヒド溶液は医療用医薬品として認可されている薬品であり、ほとんど全ての細菌、真菌、芽胞、ウイルスに有効です。医療以外では、等の殺藻剤、畜鶏舎や養鶏用器具機材の殺菌・消毒剤にも使用されています。

製法・合成法

純化方法

Likely impurities are oxidation products-acids, semialdehydes and polymers. It can be purified by repeated washing with activated charcoal (Norit) followed by vacuum filtration, using 15-20g charcoal/100mL of glutaraldehyde solution. Distil it at 60-65o/15mm, discarding the first 5-10%, then dilute with an equal volume of freshly distilled water at 70-75o, using magnetic stirring under nitrogen. The solution is stored at low temperature (3-4o), in a tightly stoppered container, and protected from light. Standardise by titration with hydroxylamine. [Anderson J Histochem Cytochem 15 652 1967, Beilstein 1 IV 3659.]