基本情報
- CAS
6915-11-3- 標準SMILES
COC1=CC(=O)CC(C)C12Oc1c(Cl)c(OC)cc(OC)c1C2=O- InChIKey
DDUHZTYCFQRHIY-UHFFFAOYSA-N- 分子式
- C17H17ClO6
- 平均分子量
- 352.8 g/mol
- 単同位体質量
- 352.071366
概要
grifulvin V has been reported in Axinella verrucosa with data available.
名称と識別子
- 優先名称
- Gris-peg
- IUPAC
- 7-chloro-3',4,6-trimethoxy-5'-methylspiro[1-benzofuran-2,4'-cyclohex-2-ene]-1',3-dione
- 英語名
- griseofulvin
- 分子量
- 0
名称と別名
Gris-PEG7-chloro-3',4,6-trimethoxy-5'-methylspiro[1-benzofuran-2,4'-cyclohex-2-ene]-1',3-dione7-chloro-3',4,6-trimethoxy-5'-methylspiro(1-benzofuran-2,4'-cyclohex-2-ene)-1',3-dioneRefChem:922504GRISEOFULVIN,ULTRAMICROSIZEGriseofulvin, ultramicrosize6915-11-37-chloro-2',4,6-trimethoxy-6'-methyl-3H-spiro[1-benzofuran-2,1'-cyclohexan]-2'-ene-3,4'-dione78739-00-1GriseostatinGrisowenMLS000028436
名称をさらに表示
Spiro[benzofuran-2(3H),1'-[2]cyclohexene]-3,4'-dione, 7-chloro-2',4,6-trimethoxy-6'-methyl- (8CI, 9CI)
NSC34533SMR0000583177-chloro-2',4,6-trimethoxy-6'-methyl-3H,4'H-spiro[1-benzofuran-2,1'-cyclohex[2]ene]-3,4'-dionedl-GriseofulvinFulvicin Bolus7-Chloro-2',4,6-trimethoxy-6'-methyl-3H-spiro[[1]benzofuran-2,1'-cyclohex[2]ene]-3,4'-dione7-chloro-4,6,12-trimethoxy-14-methylspiro[2-hydrobenzo[b]furan-2,4'-cyclohexan e]-11-ene-3,10-dioneC17H17ClO6
データベース識別子
- CAS
6915-11-3、78739-00-1- PubChem CID
- 3512
- DTXSID
DTXSID20859239
物性
構造計算による物性
- XLogP
- 2.2
- 極性表面積
- 71.1 Ų
- 水素結合供与体数
- 0
- 水素結合受容体数
- 6
- 回転可能結合数
- 3
- 重原子数
- 24
- 形式電荷
- 0
- 複雑度
- 575
実験および物理化学的性質
LogP2.33
Human Drugs
FDA approved drugs -> Active ingredient
FDA approved drugs -> Active ingredient
安全と法規制
安全情報は参考情報です。供給元の安全データシート（SDS）、適用法令、専門家による評価に代わるものではありません。
毒性情報
Exposure RoutesPoorly absorbed from GI ranging from 25 to 70% of an oral dose. Absorption is significantly enhanced by administration with or after a fatty meal.
Toxicity Summary
Griseofulvin is fungistatic, however the exact mechanism by which it inhibits the growth of dermatophytes is not clear. It is thought to inhibit fungal cell mitosis and nuclear acid synthesis. It also binds to and interferes with the function of spindle and cytoplasmic microtubules by binding to alpha and beta tubulin. It binds to keratin in human cells, then once it reaches the fungal site of action, it binds to fungal microtubes thus altering the fungal process of mitosis.
Signs and SymptomsSide effects are minor: headaches, gastrointestinal reactions and cutaneous eruptions
Carcinogen Classification2B, possibly carcinogenic to humans. (L135)
化学と産業
薬理情報
Metabolism/MetabolitesPrimarily hepatic with major metabolites being 6-methyl-griseofulvin and its glucuronide conjugate.
Half Life: 9-21 hours
MeSH Pharmacological ClassificationSubstances that destroy fungi by suppressing their ability to grow or reproduce. They differ from FUNGICIDES, INDUSTRIAL because they defend against fungi present in human or animal tissues.
用途と製造
Uses
Griseofulvin is used both in animals and in humans, to treat fungal infections of the skin (commonly known as ringworm) and nails. Griseofulvin is used orally only for dermatophytosis. It is ineffective topically. Griseofulvin is reserved for cases with nail, hair or large body surface involvement. (Wikipedia)
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