基本情報
- CAS
777-11-7- 標準SMILES
Clc1cc(Cl)c(OCC#CI)cc1Cl- InChIKey
CTETYYAZBPJBHE-UHFFFAOYSA-N- 分子式
- C9H4Cl3IO
- 平均分子量
- 361.4 g/mol
- 単同位体質量
- 359.83725
概要
Haloprogin is an aromatic ether.
名称と識別子
- 優先名称
- Haloprogin
- IUPAC
- 1,2,4-trichloro-5-(3-iodoprop-2-ynoxy)benzene
- 現地名
- ハロプロジン
- 英語名
- HALOPROGIN
- 分子式
- C9H4Cl3IO
- 分子量
- 361.39
名称と別名
haloprogin777-11-7HalotexMycandenMycilanPolikHaloprogineHaloproginaM-1028 (Meiji)HaloproginumNSC-1000713-Iodo-2-propynyl 2,4,5-trichlorophenyl ether
名称をさらに表示
ハロテクスフンガクロルポリックハロテックスハロプロギンハロプロジン2,4,5-トリクロロフェニル(3-ヨードプロパルギル)エーテル3-ヨード-2-プロピニル(2,4,5-トリクロロフェニル)エーテル2,4,5-トリクロロフェニルヨウ化プロパルギルエーテルミカンデン1,2,4-トリクロロ-5-[(3-ヨード-2-プロピニル)オキシ]ベンゼン(3-ヨード-2-プロピニル)(2,4,5-トリクロロフェニル)エーテル1-ヨード-3-(2,4,5-トリクロロフェノキシ)-1-プロピンミシランハロプロジン (JAN)m1028FungaclorHALOPROGIN (200 MG)
DTXSID9046865AIU7053OWL1,2,4-Trichloro-5-((3-iodoprop-2-yn-1-yl)oxy)benzeneM-10281,2,4-trichloro-5-[(3-iodoprop-2-yn-1-yl)oxy]benzeneBenzene, 1,2,4-trichloro-5-((3-iodo-2-propynyl)oxy)-NSC100071DTXCID7026865
データベース識別子
- CAS
777-11-7
物性
構造計算による物性
- XLogP
- 4.6
- 極性表面積
- 9.2 Ų
- 水素結合供与体数
- 0
- 水素結合受容体数
- 1
- 回転可能結合数
- 2
- 重原子数
- 14
- 形式電荷
- 0
- 複雑度
- 247
実験および物理化学的性質
Drugs
Pharmaceuticals -> Antibiotics
Pharmaceuticals -> Listed in ZINC15
LogP5.3
Solubility6.01e-03 g/L
Human Drugs
FDA approved drugs -> Active ingredient
FDA approved drugs -> Active ingredient
Melting Point
114-115
113.5 °C
Physical DescriptionSolid
物理化学的性質
- 融点
- 113 · 113-114°
- 沸点
- 477.49 °C · 477.49°C (rough estimate)
- 比重(密度)
- 1.935 · 1.9350 (estimate)
- 外見
- Solid
- 色
- White to off-white
安全と法規制
安全情報は参考情報です。供給元の安全データシート（SDS）、適用法令、専門家による評価に代わるものではありません。
GHS分類
GHS Classification
Warning
H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
P264+P265, P280, P305+P351+P338, and P337+P317 (click each P-code to see the statement)
The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.
危険有害性情報
Hazard Classes and CategoriesEye Irrit. 2 (100%)
安全データ
- rtecs
- KO1225000
- 毒性
- LD50 in mice: >3 g/kg orally and s.c.; 510 mg/kg i.p. (Seki, 1963)
- risk_code
- 22-36/37/38
- hazard_code
- Xn
- safety_code
- 26-36
化学と産業
薬理情報
ATC Code
D - Dermatologicals
QD - Dermatologicals
Pharmacodynamics
Used as a topical ointment or cream in the treatment of Tinea infections. Tinea infections are superficial fungal infections caused by three species of fungi collectively known as dermatophytes (Trichophyton, Microsporum and Epidermophyton). Commonly these infections are named for the body part affected, including tinea corporis (general skin), tinea cruris (groin), and tinea pedis (feet).
Mechanism of Action
Haloprogin is a halogenated phenolic ether administered topically for dermotaphytic infections. The mechanism of action is unknown, but is thought to be via inhibition of oxygen uptake and disruption of yeast membrane structure and function. There is a higher incidence of cutaneous side effects with haloprogin, including irritation, burning, vesiculation (blisters), scaling, and itching. It is generally used when the infection is unresponsive to other antifungals.
MeSH Pharmacological ClassificationSubstances that destroy fungi by suppressing their ability to grow or reproduce. They differ from FUNGICIDES, INDUSTRIAL because they defend against fungi present in human or animal tissues.
Cellular LocationsMembrane
応用分野
使用Antibacterial.
一般的な説明3-Iodo-2-propynyl-2,4,5-trichlorophenyl ether (Halotex)crystallizes as white to pale yellow forms that are sparinglysoluble in water and very soluble in ethanol. It is an etherealderivative of a phenol. Haloprogin is used as a 1% cream forthe treatment of superficial tinea infections.Formulations of haloprogin should be protected fromlight because the compound is photosensitive. Haloprogin isavailable as a solution and a cream, both in a 1% concentration.Haloprogin is probably not the first topical agent thatshould be recommended. Although the cure rates for topicalfungal infections are relatively high, they come at a highprice. The lesion typically worsens before it improves.Inflammation and painful irritation are common.
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