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Warning

H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]

P264, P270, P301+P317, P330, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 106 reports by companies from 2 notifications to the ECHA C&L Inventory.

Chemical: 2,4,6-Cycloheptatrien-1-one, 2-hydroxy-4-(1-methylethyl)-

2,4,6-Cycloheptatrien-1-one, 2-hydroxy-4-(1-methylethyl)-: Does not have an individual approval but may be used under an appropriate group standard

The existing information was reviewed by the independent Expert Panel for Fragrance Safety and supports the use of 2,4,6-cycloheptatrien-1-one, 2-hydroxy-4-(1-methylethyl)- as described in this safety assessment. Data show that it is not genotoxic. The repeated dose, reproductive, and local respiratory toxicity endpoints were evaluated using the Threshold of Toxicological Concern (TTC) for a Cramer Class I material, and the exposure to 2,4,6-cycloheptatrien-1-one, 2-hydroxy-4-(1-methylethyl)- is below the TTC (0.03 mg/kg/day, 0.03 mg/kg/day, and 1.4 mg/day, respectively). The skin sensitization endpoint was completed using the Dermal Sensitization Threshold (DST) for reactive materials (64 μg/cm2); exposure is below the DST. Based on data, 2,4,6-cycloheptatrien-1-one, 2-hydroxy-4-(1-methylethyl)- is a photoirritant but is not a concern under the current declared use levels. 2,4,6-Cycloheptatrien-1-one, 2-hydroxy-4-(1-methylethyl)- has not been fully evaluated for photoallergenicity.

The existing information was reviewed by the independent Expert Panel for Fragrance Safety and supports the use of 2,4,6-cycloheptatrien-1-one, 2-hydroxy-4-(1-methylethyl)- as described in this safety assessment. For the hazard assessment based on the screening data, 2,4,6-cycloheptatrien-1-one, 2-hydroxy-4-(1-methylethyl)- was found not to be Persistent, Bioaccumulative, and Toxic (PBT) as per the International Fragrance Association (IFRA) Environmental Standards, and its risk quotients, based on its current volume of use (VoU) in Europe and North America (i.e., Predicted Environmental Concentration/Predicted No Effect Concentration [PEC/PNEC]), are less than 1.

Substances that prevent infectious agents or organisms from spreading or kill infectious agents in order to prevent the spread of infection.

Agents obtained from higher plants that have demonstrable cytostatic or antineoplastic activity.

Organic chemicals that form two or more coordination links with an iron ion. Once coordination has occurred, the complex formed is called a chelate. The iron-binding porphyrin group of hemoglobin is an example of a metal chelate found in biological systems.

Fragrance Ingredients

Cosmetics -> Antistatic; Hair conditioning