Propafenone Hydrochloride

HCID 36708CAS 34183-22-7

基本情報

標準SMILES: CCCNCC(O)COc1ccccc1C(=O)CCc1ccccc1.Cl
InChIKey: XWIHRGFIPXWGEF-UHFFFAOYSA-N
分子式: C21H28ClNO3
平均分子量: 377.9 g/mol
単同位体質量: 377.17577144

概要

Propafenone hydrochloride is a hydrochloride that is the monohydrochloride salt of propafenone. It is a class 1C antiarrhythmic drug with local anesthetic effects, and is used in the management of supraventricular and ventricular arrhythmias. It has a role as an anti-arrhythmia drug. It contains a propafenone(1+).

名称と識別子

優先名称: Propafenone Hydrochloride
IUPAC: 1-[2-[2-hydroxy-3-(propylamino)propoxy]phenyl]-3-phenylpropan-1-one;hydrochloride

名称と別名

PROPAFENONE HYDROCHLORIDE34183-22-7Propafenone HClRythmol SRBaxarytmonPropafenon hydrochlorid1-(2-(2-Hydroxy-3-(propylamino)propoxy)phenyl)-3-phenylpropan-1-one hydrochloride33XCH0HOCD1-[2-[2-hydroxy-3-(propylamino)propoxy]phenyl]-3-phenylpropan-1-one hydrochlorideNSC-7586401-{2-[2-hydroxy-3-(propylamino)propoxy]phenyl}-3-phenylpropan-1-one hydrochloride2'-(2-Hydroxy-3-(propylamino)propoxy)-3-phenylpropiophenone hydrochloride

名称をさらに表示

Hydrochloride, Propafenone1-Propanone, 1-(2-(2-hydroxy-3-(propylamino)propoxy)phenyl)-3-phenyl-, hydrochlorideCHEBI:8466DTXSID1010172332'-[2-Hydroxy-3-(propylamino)propoxy]-3-phenylpropiophenone HydrochlorideRefChem:55925DTXCID7014754251-(2-((2RS)-2-Hydroxy-3-(propylamino)propyloxy)phenyl)-3-phenylpropan-1-one monohydrochloride

データベース識別子

CAS: 34183-22-7
PubChem CID: 36708
DTXSID: DTXSID101017233
ChEMBL: CHEMBL1201063
ChEBI: CHEBI:8466
UNII: 33XCH0HOCD
EC Number: 251-867-9

物性

構造計算による物性

極性表面積: 58.6 Å²
水素結合供与体数: 3
水素結合受容体数: 4
回転可能結合数: 11
重原子数: 26
形式電荷: 0
複雑度: 368

実験および物理化学的性質

Solubility>56.7 [ug/mL] (The mean of the results at pH 7.4)

Human Drugs · 2 件

FDA approved drugs -> Active ingredient

Collision Cross Section177.2 Å² [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]

安全と法規制

GHS分類

GHS Classification · 4 件

Warning

H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]

P261, P264, P270, P271, P280, P301+P317, P302+P352, P304+P340, P317, P321, P330, P362+P364, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 154 reports by companies from 6 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

危険有害性情報

Hazard Classes and CategoriesAcute Tox. 4 (100%)

毒性情報

Drug Induced Liver Injury · 6 件

Drug Induced Liver Injury Rank (DILIrank 2.0)

Propafenone hydrochloride

vLess-DILI-concern

Adverse reactions

DOI:10.1016/j.drudis.2016.02.015

化学と産業

薬理情報

FDA Pharmacological Classification · 2 件

PROPAFENONE HYDROCHLORIDE

Antiarrhythmic [EPC]

MeSH Pharmacological Classification · 2 件

Agents used for the treatment or prevention of cardiac arrhythmias. They may affect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers. Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade.

A class of drugs that inhibit the activation of VOLTAGE-GATED SODIUM CHANNELS.