2-メルカプトベンゾチアゾールナトリウム

1.25 to 1.28 at 77 °F (NTP, 1992)

DENSITY 10.5 LB/GAL (50% AQ SOLN)

greater than or equal to 100 mg/mL at 68 °F (NTP, 1992)

Sol in water.

Danger

H314 (95.4%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]

P260, P261, P264, P264+P265, P272, P273, P280, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P354+P338, P316, P317, P321, P333+P317, P362+P364, P363, P391, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 938 reports by companies from 21 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Warning

H317 (100%): May cause an allergic skin reaction [Warning Sensitization, Skin]

Chemical: 2(3H)-Benzothiazolethione, sodium salt (1:1)

2(3H)-Benzothiazolethione, sodium salt (1:1) is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of 2(3H)-Benzothiazolethione, sodium salt (1:1) are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

Status: Active Update: 21-12-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/2140

Sodium 2-mercaptobenzothiazole: Does not have an individual approval but may be used under an appropriate group standard

Contact with moisture in the body by inhalation may yield sodium hydroxide (corrosive) and 2-mercaptabenzothiazole, an irritant. Contact with the eyes caused opacity or ulceration of the cornea, inflammation of the iris, redness and swelling of the conjunctiva and partial eversion of the eye lids, and destruction or irreversible tissue change in 24 hours or less (rabbit). A dose of 2,500 mg/kg applied to the skin caused severe depression, cold extremities, appetite loss; 4 of 10 died. Exposure of the skin to 1,250 mg/kg caused a severe degree of skin injury. The skin was burned in 24 hours with formation of hard eschar at 1-2 weeks; 1 of 10 rabbits died. Ingestion caused tremors, convulsions, severe depression and hemaluria in male rats. Ingestion of 312.5 mg/kg: 1 of 5 male rats die on day 2; 625 mg/kg: 2 of 5 died within 3-5 minutes; 1,250 mg/kg: 3 of 5 died within 3-5 minutes; 2,500 mg/kg: 100% mortality within 3-5 minutes. Hemorrhage of the stomach occurred in all rats that died. (USCG, 1999)

In in vitro studies mercaptobenzothiazole (MBT) (5x10-6 M) inhibited dopamine-beta-hydroxylase (an enzyme involved in the synthesis of norepinephrine) activity by 47%. In in vivo studies MBT (200 mg/kg, ip) lowered norepinephrine levels of mouse brain by 40% at 1 hr after injection; possibly by chelation of cupric ions necessary for dopamine-beta-hydroxylase activity./Mercaptobenzothiazole/

...Rats... were dosed ip with 35S-mercapto-labelled 2-mercaptobenzothiazole. Analysis of urinary metabolites indicated that mercaptobenzothiazole underwent conjugation with glutathione and with glucuronic acid. Radiolabelled inorg sulfate was also identified in urine. /Mercaptobenzothiazole/

At an in vitro concn of 1mM mercaptobenzothiazole caused a slow inhibition of the hexose monophosphate pathway and a moderate stimulation of the tricarboxylic acid cycle of Ehrlich ascites tumor cells./Mercaptobenzothiazole/

The percutaneous absorption of mercaptobenzothiazole in aqueous soln was studied in guinea pigs. [14C]-labeled mercaptobenzothiazole (about 11 mg/kg body weight) was applied to the shaved skin of the test animals ... Radioactivity in the tissues and excreta was monitored for up to 48 hr. At 48 hr the following distribution of radioactivity (percent of applied dose) was observed following application to intact (abraded) skin: blood: 0.08 (0.17); internal organs: 0.02 (0.05); GI contents: 0.02 (0.03); feces: 0.46 (1.92); urine: 8.39 (34.58); skin (at application site): 12.13 (7.29); coverings and washings: 60.97 (39.10) /from table/. Max rate of absorption was observed at 3 to 6 hours after application as measured by radioactivity in the urine.

The tissue distribution and excretion of mercaptobenzothiazole was studied in guinea pigs injected sc with [14C]-labeled aqueous soln of mercaptobenzothiazole (5 mg/kg). Max values of radioactivity were observed in tissues at 15 min after injection, and thereafter the radioactivity decr rapidly with time. At 1 hr afr dosing highest values of radioactivity were observed in kidney, liver, and thyroid. At 48 hr the highest values were observed in the thyroid. Excretion of the cmpd appeared to be rapid. At 6 hr after dosing 92.6% of the applied dose had been recovered in urine.