2-ヨードアセトアミド

Iodoacetamide

HCID 3727CAS 144-48-9

基本情報

標準SMILES
NC(=O)CI
InChIKey
PGLTVOMIXTUURA-UHFFFAOYSA-N
分子式
C2H4INO
平均分子量
184.96 g/mol
単同位体質量
184.93376175

概要

Iodoacetamide is a sulfhydryl alkylating reagent that forms covalent bonds with the thiol group of cysteines so the protein or peptide no longer forms disulfide bonds.

名称と識別子

優先名称
Iodoacetamide
IUPAC
2-iodoacetamide
現地名
2-ヨードアセトアミド
英語名
2-Iodoacetamide
分子式
C2H4INO
分子量
184.96

名称と別名

2-Iodoacetamideiodoacetamide144-48-9SurautoACETAMIDE, 2-IODO-MonoiodoacetamideDTXSID9020742N-(3-Methoxy-4-butoxybenzyl)thiobarbituric acidZRH8M27S79NSC-9581DTXCID10742RefChem:389075
名称をさらに表示
2-ヨードアセトアミドヨードアセトアミド ヨウ化物ヨードアセトアミドヨードエタンアミドモノヨド酢酸アミド2-ヨードアセトアミド [生化学用]IAMIODACETAMIDEusafd-12-IodacetamidIodoethanamide2-iodo-acetamid
205-630-1USAF D-1MFCD00008028CCRIS 7710.alpha.-IodoacetamideAI3-518412-Iodo-acetamidealpha-Iodoacetamide

データベース識別子

CAS
144-48-9
PubChem CID
3727
DTXSID
DTXSID9020742
ChEMBL
CHEMBL276727
UNII
ZRH8M27S79
EC Number
205-630-1
Nikkaji
J3.270K

物性

構造計算による物性

XLogP
-0.2
極性表面積
43.1 Ų
水素結合供与体数
1
水素結合受容体数
1
回転可能結合数
1
重原子数
5

実験および物理化学的性質

Chemical ClassesNitrogen Compounds -> Other Nitrogen Compounds
SpringerMaterials PropertiesSchoenflies notation
LogP-0.19
Vapor Pressure0.00506 [mmHg]
Physical DescriptionCrystalline solid; [Sigma-Aldrich MSDS]

物理化学的性質

融点
92 · 92-95 °C(lit.)
沸点
297.1 · 297.1±23.0 °C(Predicted)
比重(密度)
2.1103 · 2.1103 (estimate)
貯蔵温度
2 · 2-8°C
溶解性
2 O: · H2O: 0.5M at20℃、透明、無色
外見
結晶性

化学的性質

化学的特性White solid in amber, foil sealed microtubes. Soluble in hot water, easily soluble in ethanol.

安全と法規制

GHS分類

GHS Classification · 4 件

Danger

H301 (99%): Toxic if swallowed [Danger Acute toxicity, oral]

P233, P260, P261, P264, P270, P271, P272, P273, P280, P284, P301+P316, P302+P352, P304+P340, P321, P330, P333+P317, P342+P316, P362+P364, P403, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 192 reports by companies from 14 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

危険有害性情報

Regulatory Information · 2 件

Chemical: Acetamide, 2-iodo-

2-Iodoacetamide: Does not have an individual approval but may be used under an appropriate group standard

Hazards Summary · 1 件

Causes ulceration or bleeding from the stomach and other GI changes in 74-week intermittent oral studies of rats; [RTECS] May cause irritation; May cause skin and respiratory sensitization; Toxic by ingestion; [Sigma-Aldrich MSDS] See Chloroacetamide.

Hazard Classes and CategoriesAcute Tox. 3 (99%)

毒性情報

Adverse EffectsSkin Sensitizer - An agent that can induce an allergic reaction in the skin.

安全データ

F
8-10-21
wgk
3
tsca
TSCA listed
rtecs
AC4200000
ridadr
UN 2811 6.1/PG 3
hs_code
29241900

化学と産業

薬理情報

MeSH Pharmacological Classification · 2 件

Highly reactive chemicals that introduce alkyl radicals into biologically active molecules and thereby prevent their proper functioning. Many are used as antineoplastic agents, but most are very toxic, with carcinogenic, mutagenic, teratogenic, and immunosuppressant actions. They have also been used as components in poison gases.

Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.

用途と製造

UsesAn alkylating sulfhydryl reagent with action similar to iodoacetate; [ChemIDplus]
General Manufacturing InformationAcetamide, 2-iodo-: ACTIVE
応用分野 · 3 件

用途合成原料(SH基修飾剤)。

用途タンパク質SH基修飾剤。

使用2-Iodoacetamide is an alkylating reagent for cysteine residues in peptide sequencing. Its actions are similar to those of iodoacetate. By virtue of reaction with cysteine, it is an irreversible inhibitor of enzymes with cysteine at the active site. It reacts much more slowly with histidine residues, but that activity is responsible for inhibition of ribonuclease.

調製方法

純化方法Crystallise it from water or CCl4. It is used for tagging proteins. [Gurd Methods Enzymol 25 424 1972, Beilstein 2 IV 536.]

サプライヤー50 社

国药集团化学试剂有限公司86-21-63210123 · [email protected]
北京华美互利生物化工010-56205725 · [email protected]
梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]
衢州润东化工有限公司0570-8789886 18892685668 · [email protected]
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]

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