基本情報
- CAS
36637-18-0- 標準SMILES
CCCN(CC)C(CC)C(=O)Nc1c(C)cccc1C- InChIKey
VTUSIVBDOCDNHS-UHFFFAOYSA-N- 分子式
- C17H28N2O
- 平均分子量
- 276.4 g/mol
- 単同位体質量
- 276.22016352
概要
Etidocaine is an amino acid amide in which 2-[ethyl(propyl)amino]butanoic acid and 2,6-dimethylaniline have combined to form the amide bond. Used as a local anaesthetic (amide caine), it has rapid onset and long action properties, similar to bupivacaine, and is given by injection during surgical procedures and during labour and delivery. It has a role as a local anaesthetic.
名称と識別子
- 優先名称
- Etidocaine
- IUPAC
- N-(2,6-dimethylphenyl)-2-[ethyl(propyl)amino]butanamide
- 現地名
- エチドカイン
- 英語名
- Etidocaine
- 分子式
- C17H28N2O
- 分子量
- 276.42
名称と別名
Etidocaine36637-18-0EtidocainaN-(2,6-dimethylphenyl)-2-[ethyl(propyl)amino]butanamideEtidocainumDTXSID10230272-(Ethylpropylamino)-2',6'-butyroxylidideI6CQM0F31V(+-)-N-(2,6-Dimethylphenyl)-2-(ethylpropylamino)butanamideCHEBI:4904W-19053 FREE BASEDTXCID703027
名称をさらに表示
ズラネストrac-(2R*)-N-(2,6-ジメチルフェニル)-2-[エチル(プロピル)アミノ]ブチルアミドエチドカインrac-(R*)-N-(2,6-ジメチルフェニル)-2-[エチル(プロピル)アミノ]ブタンアミドW-19053DuranestEtidocaine HCLEtidocaine USP/EP/BPEtidocaine, 10 mM in DMSOEDC,Inhibitor,inhibit,Etidocaine,anestheticsButanaMide, N-(2,6-diMethylphenyl)-2-(ethylpropylaMino)-
Butanamide, N-(2,6-dimethylphenyl)-2-(ethylpropylamino)-, (+-)-Duranest (as hydrochloride)Duranest [as hydrochloride]N-(2,6-dimethylphenyl)-2-(ethyl-propylamino)butanamideN-(2,6-dimethylphenyl)-2-(ethyl(propyl)amino)butanamideRefChem:388963N01BB07253-143-8
データベース識別子
- CAS
36637-18-0、38188-41-9、38188-42-0、60108-68-1- PubChem CID
- 37497
- DTXSID
DTXSID1023027- ChEMBL
CHEMBL492- ChEBI
CHEBI:4904- UNII
- I6CQM0F31V、K9D2CE52PU、Y83XVY9AQ8
- EC Number
- 253-143-8
- Nikkaji
- J67.488E
物性
構造計算による物性
- XLogP
- 3.7
- 極性表面積
- 32.3 Ų
- 水素結合供与体数
- 1
- 水素結合受容体数
- 2
- 回転可能結合数
- 7
- 重原子数
- 20
- 形式電荷
- 0
- 複雑度
- 283
実験および物理化学的性質
LogP3.22
Human DrugsPharmaceuticals
Melting Point203-203.5
物理化学的性質
- 沸点
- 389.7 · 389.7±30.0 °C(Predicted)
- 比重(密度)
- 0.993 · 0.993±0.06 g/cm3(Predicted)
- 酸解離定数(Pka)
- 14.18 · 14.18±0.70(Predicted)
化学と産業
薬理情報
ATC Code
N - Nervous system
QN - Nervous system
MeSH Pharmacological Classification
Drugs that block nerve conduction when applied locally to nerve tissue in appropriate concentrations. They act on any part of the nervous system and on every type of nerve fiber. In contact with a nerve trunk, these anesthetics can cause both sensory and motor paralysis in the innervated area. Their action is completely reversible. (From Gilman AG, et. al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed) Nearly all local anesthetics act by reducing the tendency of voltage-dependent sodium channels to activate.
用途と製造
Use ClassificationPharmaceuticals
応用分野
使用Anesthetic (local).
上流・下流製品情報
上流原料
サプライヤー11 社
Hangzhou Sage Chemical Co., Ltd.+86057186818502 13588463833 · [email protected]
上海陶术生物科技股份有限公司+1-781-999-5354; +1-00000000000 · [email protected]
河北方乾新材料科技有限公司86-180-3439-5858-5858 18034395858
成都标样生物科技有限公司028-81700200 13308200041 · [email protected]
Shaanxi Didu New Materials Co. Ltd+86-86-17392712779 +86-13289823923 · [email protected]
杭州洁汉化工有限公司+86-571-86217390; +8618058761490 · [email protected]
Xiamen Wonderful Bio Technology Co., Ltd.+86-13043004613 · [email protected]
上海一飞生物科技有限公司021-65675885 18964387627 · [email protected]
TargetMol中国（陶术生物）15002134094 · [email protected]
上海陶术生物科技股份有限公司+1-781-999-5354 · [email protected]
上海阿摩尔生物科技有限公司13370042665 18916960931 · [email protected]
補足説明
定義ChEBI: An amino acid amide in which 2-[ethyl(propyl)amino]butanoic acid and 2,6-dimethylaniline have combined to form the amide bond. Used as a local anaesthetic (amide caine), it has rapid onset and long action properties, similar to bupivacaine, and is given b injection during surgical procedures and during labour and delivery.
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