基本情報
- CAS
36519-31-0- 標準SMILES
CC(C)(C)NCC(O)c1ccc(O)c(CO)c1.CC(C)(C)NCC(O)c1ccc(O)c(CO)c1.O=S(=O)(O)O- InChIKey
BNPSSFBOAGDEEL-UHFFFAOYSA-N- 分子式
- C26H44N2O10S
- 平均分子量
- 576.7 g/mol
- 単同位体質量
- 576.27166678
概要
Albuterol sulfate is an ethanolamine sulfate salt. It is functionally related to an albuterol.
名称と識別子
- 優先名称
- Albuterol Sulfate
- IUPAC
- bis(4-[2-(tert-butylamino)-1-hydroxyethyl]-2-(hydroxymethyl)phenol);sulfuric acid
- 現地名
- サルブタモールヘミ硫酸塩
- 英語名
- SALBUTAMOL HEMISULFATE
- 分子式
- C13H23NO7S
- 分子量
- 337.38922
名称と別名
ALBUTEROL SULFATEVenetlinLoftanVolmaxSalbutamol SulphateAccuNebProventil-HFAVentolin RotacapsSch 13949W sulfateProAirProair RespiclickVentolin HFA
名称をさらに表示
サルブタモールヘミ硫酸塩dl-salbutamolsulfate(+-)-ysulfate(2:1)(salt)
VoSpire ERSultanolVentilastinBuventolEcoventSalbumolAlbuterol SulphateProair HFA
データベース識別子
- CAS
36519-31-0、51022-70-9、67713-16-0- PubChem CID
- 39859
- DTXSID
DTXSID10881180- ChEMBL
CHEMBL1441059- ChEBI
CHEBI:2550- UNII
- 021SEF3731
- EC Number
- 690-790-9
物性
構造計算による物性
- 極性表面積
- 228 Ų
- 水素結合供与体数
- 10
- 水素結合受容体数
- 12
- 回転可能結合数
- 10
- 重原子数
- 39
- 形式電荷
- 0
- 複雑度
- 309
実験および物理化学的性質
Human Drugs
Breast Feeding; Lactation; Milk, Human; Anti-Asthmatic Agents; Bronchodilator Agents; Beta Adrenergic Agonists
FDA approved drugs -> Active ingredient
FDA approved drugs -> Active ingredient
Animal DrugsFDA approved animal drugs -> Active ingredient
安全と法規制
安全情報は参考情報です。供給元の安全データシート（SDS）、適用法令、専門家による評価に代わるものではありません。
GHS分類
GHS ClassificationNot Classified
危険有害性情報
DOT Hazard Classification
Hexotonal
UN0393
Div 1.1 Explosives (with a mass explosion hazard) (49 eCFR § 173.50)
Hazard Classes and CategoriesNot Classified
DHS Chemicals of Interest (COI)
Torpex
A Commercial Grade
5000
A Commercial Grade
400
Explosive chemical that can be released at a facility.
毒性情報
Exposure RoutesSystemic absorption is rapid following aerosol administration.
Toxicity Summary
Salbutamol is a beta(2)-adrenergic agonist and thus it stimulates beta(2)-adrenergic receptors. Binding of albuterol to beta(2)-receptors in the lungs results in relaxation of bronchial smooth muscles. It is believed that salbutamol increases cAMP production by activating adenylate cyclase, and the actions of salbutamol are mediated by cAMP. Increased intracellular cyclic AMP increases the activity of cAMP-dependent protein kinase A, which inhibits the phosphorylation of myosin and lowers intracellular calcium concentrations. A lowered intracellular calcium concentration leads to a smooth muscle relaxation and bronchodilation. In addition to bronchodilation, salbutamol inhibits the release of bronchoconstricting agents from mast cells, inhibits microvascular leakage, and enhances mucociliary clearance.
Carcinogen ClassificationNo indication of carcinogenicity to humans (not listed by IARC).
化学と産業
薬理情報
Metabolism/Metabolites
Hydrolyzed by esterases in tissue and blood to the active compound colterol. The drug is also conjugatively metabolized to salbutamol 4'-O-sulfate. Route of Elimination: Approximately 72% of the inhaled dose is excreted in the urine within 24 hours, 28% as unchanged drug and 44% as metabolite. Half Life: 1.6 hours
FDA Pharmacological Classification
ALBUTEROL SULFATE
Adrenergic beta2-Agonists [MoA]; beta2-Adrenergic Agonist [EPC]
MeSH Pharmacological Classification
Agents that cause an increase in the expansion of a bronchus or bronchial tubes.
Drugs that prevent preterm labor and immature birth by suppressing uterine contractions (TOCOLYSIS). Agents used to delay premature uterine activity include magnesium sulfate, beta-mimetics, oxytocin antagonists, calcium channel inhibitors, and adrenergic beta-receptor agonists. The use of intravenous alcohol as a tocolytic is now obsolete.
Compounds bind to and activate ADRENERGIC BETA-2 RECEPTORS.
用途と製造
UsesFor symptomatic relief and prevention of bronchospasm due to bronchial asthma, chronic bronchitis, and other chronic bronchopulmonary disorders such as COPD.
サプライヤー4 社
湖北海克斯生化有限公司17362916295; 17362916295 · [email protected]
Shenzhen Excellent Biotech Co., Ltd.13480692018 · [email protected]
南京克罗托鲁宁医药科技有限公司13382066392
Hefei TNJ Chemical Industry Co.,Ltd.
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