カルテオロール·塩酸塩

Carteolol Hydrochloride

HCID 40127

基本情報

CAS
51781-21-6
標準SMILES
CC(C)(C)NCC(O)COc1cccc2c1CCC(=O)N2.Cl
InChIKey
FYBXRCFPOTXTJF-UHFFFAOYSA-N
分子式
C16H25ClN2O3
平均分子量
328.83 g/mol
単同位体質量
328.1553704

概要

Carteolol Hydrochloride is a synthetic quinolinone derivative, antihypertensive Carteolol Hydrochloride is a nonselective beta-adrenoceptor blocking agent for beta-1 and beta-2 receptors with no membrane-stabilizing activity but moderate intrinsic sympathomimetic effects. It is used for treatment of hypertension and certain arrhythmias, and as an anti-angina and antiglaucoma agent. (NCI04)

名称と識別子

優先名称
Carteolol Hydrochloride
IUPAC
5-[3-(tert-butylamino)-2-hydroxypropoxy]-3,4-dihydro-1H-quinolin-2-one;hydrochloride
現地名
カルテオロール·塩酸塩
英語名
Carteolol hydrochloride
分子式
C16H25ClN2O3
分子量
328.83

名称と別名

carteolol hydrochloride51781-21-6Carteolol HClCartrolOcupressAbbott-43326OPC-1085TeopticDTXSID4045478NSC-3009064797W6I0T4DTXCID2025478
名称をさらに表示
ブロキレートリエントンカルテロールチスタロールカルテロカルテオロールTブロキレートPF5-[3-[(1,1-ジメチルエチル)アミノ]-2-ヒドロキシプロポキシ]-3,4-ジヒドロキノリン-2(1H)-オン·塩酸塩ブロックビーメルカトアチオグールミケランLAオルカロールカルノノンミケランランテロール塩酸カルテオロールカルテオロール·塩酸塩ベタメノールカルテオロール塩酸塩endakoc1085TenaletCarteolCartelomikelanopc1085
5-(2-Hydroxy-3-tert-butylamino)propoxy-3,4-dihydrocarbostyril hydrochloride5-(3-(tert-Butylamino)-2-hydroxypropoxy)-3,4-dihydrocarbostyril monohydrochlorideNSC3009065-(3-((1,1-Dimethylethyl)amino)-2-hydroxypropoxy)-3,4-dihydro-2(1H)-quinolinone hydrochloride5-(3-tert-Butylamino-2-hydroxy-propoxy)-3,4-dihydro-2(1H)-chinolinon-hydrochloridCHEBI:34385-[3-(tert-Butylamino)-2-hydroxypropoxy]-3,4-dihydrocarbostyril monohydrochloride5-[3-[(1,1-Dimethylethyl)amino]-2-hydroxypropoxy]-3,4-dihydro-2(1H)-quinolinone Hydrochloride

データベース識別子

CAS
51781-21-6
PubChem CID
40127
DTXSID
DTXSID4045478
ChEMBL
CHEMBL1201002
UNII
4797W6I0T4
EC Number
257-415-7

物性

構造計算による物性

極性表面積
70.6 Ų
水素結合供与体数
4
水素結合受容体数
4
回転可能結合数
6
重原子数
22

実験および物理化学的性質

Human Drugs · 3 件

Breast Feeding; Lactation; Milk, Human; Adrenergic Beta-Antagonists; Antiglaucoma Agents

FDA approved drugs -> Active ingredient

FDA approved drugs -> Active ingredient

物理化学的性質

融点
278 °C · 278°C
貯蔵温度
Refrigerator
溶解性
96 %エタノールに溶けにくく、ジクロロメタンにほとんど溶けない。 · 水に溶け、メタノールに溶けにくく、96%エタノールに溶けにくく、ジクロロメタンにほとんど溶けない。
外見
Solid
色
ホワイトからオフホワイト
Merck
14 · 14,1866

化学的性質

化学的特性Crystalline Solid

安全と法規制

GHS分類

GHS Classification · 5 件

This chemical does not meet GHS hazard criteria for 16.7% (1 of 6) of reports.

Warning

H302 (83.3%): Harmful if swallowed [Warning Acute toxicity, oral]

P203, P264, P264+P265, P270, P280, P301+P317, P305+P351+P338, P318, P330, P337+P317, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 6 reports by companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

危険有害性情報

Hazard Classes and CategoriesAcute Tox. 4 (83.3%)

毒性情報

Effects During Pregnancy and Lactation◉ Summary of Use during Lactation

安全データ

rtecs
VC8282000
毒性
LD50 in male mice, rats (mg/kg): 810, 1380 orally; 54.5, 158 i.v.; 380, 400 i.p. (Lang)
hs_code
2933790002

化学と産業

薬理情報

FDA Pharmacological Classification · 2 件

CARTEOLOL HYDROCHLORIDE

Adrenergic beta-Antagonists [MoA]; beta-Adrenergic Blocker [EPC]

MeSH Pharmacological Classification · 4 件

Drugs that bind to but do not activate beta-adrenergic receptors thereby blocking the actions of beta-adrenergic agonists. Adrenergic beta-antagonists are used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches, and anxiety.

Agents used for the treatment or prevention of cardiac arrhythmias. They may affect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers. Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade.

Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS.

Drugs that inhibit the actions of the sympathetic nervous system by any mechanism. The most common of these are the ADRENERGIC ANTAGONISTS and drugs that deplete norepinephrine or reduce the release of transmitters from adrenergic postganglionic terminals (see ADRENERGIC AGENTS). Drugs that act in the central nervous system to reduce sympathetic activity (e.g., centrally acting alpha-2 adrenergic agonists, see ADRENERGIC ALPHA-AGONISTS) are included here.

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