基本情報
- CAS
51781-21-6- 標準SMILES
CC(C)(C)NCC(O)COc1cccc2c1CCC(=O)N2.Cl- InChIKey
FYBXRCFPOTXTJF-UHFFFAOYSA-N- 分子式
- C16H25ClN2O3
- 平均分子量
- 328.83 g/mol
- 単同位体質量
- 328.1553704
概要
Carteolol Hydrochloride is a synthetic quinolinone derivative, antihypertensive Carteolol Hydrochloride is a nonselective beta-adrenoceptor blocking agent for beta-1 and beta-2 receptors with no membrane-stabilizing activity but moderate intrinsic sympathomimetic effects. It is used for treatment of hypertension and certain arrhythmias, and as an anti-angina and antiglaucoma agent. (NCI04)
名称と識別子
- 優先名称
- Carteolol Hydrochloride
- IUPAC
- 5-[3-(tert-butylamino)-2-hydroxypropoxy]-3,4-dihydro-1H-quinolin-2-one;hydrochloride
- 現地名
- カルテオロール·塩酸塩
- 英語名
- Carteolol hydrochloride
- 分子式
- C16H25ClN2O3
- 分子量
- 328.83
名称と別名
名称をさらに表示
データベース識別子
- CAS
51781-21-6- PubChem CID
- 40127
- DTXSID
DTXSID4045478- ChEMBL
CHEMBL1201002- UNII
- 4797W6I0T4
- EC Number
- 257-415-7
物性
構造計算による物性
- 極性表面積
- 70.6 Ų
- 水素結合供与体数
- 4
- 水素結合受容体数
- 4
- 回転可能結合数
- 6
- 重原子数
- 22
- 形式電荷
- 0
- 複雑度
- 354
実験および物理化学的性質
Human Drugs
Breast Feeding; Lactation; Milk, Human; Adrenergic Beta-Antagonists; Antiglaucoma Agents
FDA approved drugs -> Active ingredient
FDA approved drugs -> Active ingredient
物理化学的性質
- 融点
- 278 °C · 278°C
- 貯蔵温度
- Refrigerator
- 溶解性
- 96 %エタノールに溶けにくく、ジクロロメタンにほとんど溶けない。 · 水に溶け、メタノールに溶けにくく、96%エタノールに溶けにくく、ジクロロメタンにほとんど溶けない。
- 外見
- Solid
- 色
- ホワイトからオフホワイト
- Merck
- 14 · 14,1866
- InChI
- InChI=1S/C16H24N2O3.ClH/c1-16(2,3)17-9-11(19)10-21-14-6-4-5-13-12(14)7-8-15(20)18-13;/h4-6,11,17,19H,7-10H2,1-3H3,(H,18,20);1H
- InChIKey
- FYBXRCFPOTXTJF-UHFFFAOYSA-N
- SMILES
- C12CCC(=O)NC=1C=CC=C2OCC(O)CNC(C)(C)C.Cl
化学的性質
化学的特性Crystalline Solid
安全と法規制
GHS分類
GHS Classification
This chemical does not meet GHS hazard criteria for 16.7% (1 of 6) of reports.
Warning
H302 (83.3%): Harmful if swallowed [Warning Acute toxicity, oral]
P203, P264, P264+P265, P270, P280, P301+P317, P305+P351+P338, P318, P330, P337+P317, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 6 reports by companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
危険有害性情報
毒性情報
安全データ
- rtecs
- VC8282000
- 毒性
- LD50 in male mice, rats (mg/kg): 810, 1380 orally; 54.5, 158 i.v.; 380, 400 i.p. (Lang)
- hs_code
- 2933790002
化学と産業
薬理情報
FDA Pharmacological Classification
CARTEOLOL HYDROCHLORIDE
Adrenergic beta-Antagonists [MoA]; beta-Adrenergic Blocker [EPC]
MeSH Pharmacological Classification
Drugs that bind to but do not activate beta-adrenergic receptors thereby blocking the actions of beta-adrenergic agonists. Adrenergic beta-antagonists are used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches, and anxiety.
Agents used for the treatment or prevention of cardiac arrhythmias. They may affect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers. Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade.
Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS.
Drugs that inhibit the actions of the sympathetic nervous system by any mechanism. The most common of these are the ADRENERGIC ANTAGONISTS and drugs that deplete norepinephrine or reduce the release of transmitters from adrenergic postganglionic terminals (see ADRENERGIC AGENTS). Drugs that act in the central nervous system to reduce sympathetic activity (e.g., centrally acting alpha-2 adrenergic agonists, see ADRENERGIC ALPHA-AGONISTS) are included here.
上流・下流製品情報
下流製品
サプライヤー100 社
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