メベンダゾール

用途メベンダゾール（Mebendazole、MBZ）は、ベンゾイミダゾール系の駆虫薬であり、スペクトラムが広い、すなわち多くの寄生虫治療に用いる事のできる医薬品である。回虫症、蟯虫感染症（英語版）、鉤虫感染症（英語版）[要リンク修正]、メジナ虫症、エキノコックス症、ジアルジア症等がある。

説明Mebendazole is a broad-spectrum anthelmintic that is active against both larval and adult stages of nematodes selectively binding the β-subunit of tubulin, thereby inhibiting intestinal microtubule synthesis in the parasite (IC50 = 0.19 μM for Giardia in vitro). As a tubulin-binding agent, mebendazole also possesses antitumor properties, inducing apoptosis of various human carcinomas both in vitro and in vivo, thus preventing their growth and migration. Furthermore, mebendazole has been used to inhibit hedgehog signaling in cancer cells via suppression of the formation of the primary cilium, a microtubule-based organelle that functions as a signaling hub for hedgehog pathway activation. Additionally, mebendazole has been shown to stabilize the transcriptional activator HIF-1α and its downstream targets, abrogating oxidative neuronal death in primary neurons.

使用Mebendazole Polymorph C is an Anthelmintic (Nematodes).

一般的な説明White to slightly yellow powder. Pleasant taste. Practically water insoluble.