ポビドンヨード
ポリドンヨ-ド · ポリビニルピロリドン-よう素錯体 · ポビドンヨード · イソジン · ポリビニルピロリドン‐よう素錯体 · ポビドンよう素 · ポビドン-よう素 · ポリ(ビニルピロリドン)-ヨウ素錯体
識別子と物理属性
| CAS No. | 25655-41-8 |
|---|---|
| 分子式 | C6H9I2NO |
| 平均分子量 | 364.95 g/mol |
| SMILES | C=CN1CCCC1=O.II |
| InChIKey | FAAHNQAYWKTLFD-UHFFFAOYSA-N |
| PubChem CID | 410087 |
| ChEMBL | CHEMBL5424182 |
| 現地名 | ポビドンヨード |
化学・物理的性質
| 極性表面積 | 20.3 |
|---|---|
| 水素結合供与体数 | 0 |
| 水素結合受容体数 | 1 |
| 回転可能結合数 | 1 |
| 重原子数 | 10 |
| 形式電荷 | 0 |
| 複雑度 | 120 |
| 融点 | 300 °C |
| 貯蔵条件 | Keep in dark place,Inert atmosphere,Room temperature |
| 溶解度 | H2O: ソリュブル100mg/mL水、エタノール、イソプロパノール、ポリエチレングリコール、グリセロールに可溶。クロロホルム、四塩化炭素、ヘキサン、アセトン、石油エーテルに不溶。 |
| 外観・状態 | 粉 |
| 色 | 黄褐色 |
| 臭い | ylsh. brn. amorphous powd., sl. char. odor |
| Merck | 13,7784 |
| 化粧品成分の機能 | 抗菌剤 |
| InChI | InChI=1S/C6H9NO.I2/c1-2-7-5-3-4-6(7)81-2/h2H,1,3-5H2 |
| InChIKey | FAAHNQAYWKTLFD-UHFFFAOYSA-N |
| SMILES | II.C(N1CCCC1=O)=C |
| CAS データベース | 25655-41-8(CAS DataBase Reference) |
| EPAの化学物質情報 | Povidone-iodine (25655-41-8) |
化学的特性
Povidone iodine is a complex of iodine with povidone. It occurs as a yellowish brown to reddish brown amorphous powder, having a slight characteristic odour. Its solution is acid to litmus. Soluble in water and in alcohol, practically insoluble in chloroform, in carbon tetrachloride, in ether, in solvent hexane, and in acetone. It is an external antiseptic with a broad microbicidal spectrum against bacteria, fungi, viruses, protozoa, and yeasts. This gel has about 1.0% available iodine.
安全性と法規制
| 水環境危害等級（WGK） | 2 |
|---|---|
| TSCA 収載状態 | TSCA listed |
| RTECS 番号 | TR1579600 |
| 税関コード | 29339900 |
| 安全措置（S） | 24/25-22 |
| 危険等級 | Aquatic Chronic 2Eye Dam. 1Skin Irrit. 2 |
| 貯蔵分類 | 11 - Combustible Solids |
| 有害物質データ | 25655-41-8(Hazardous Substances Data) |
用途
用途
ポビドンヨード（英語povidone iodine）とは、1-ビニル-2-ピロリドンの重合物（ポリビニルピロリドン）とヨウ素の複合体であり、日本薬局方にも収載されている医薬品（ヨウ素剤）である。通常、10%程度の水溶液にし、外用消毒薬として用いる。液剤は黒褐色であり、ヨウ素の特異な匂いと味がする。 ポビドンヨードはWHO必須医薬品モデル?リストに掲載されている殺菌剤の一つである。
説明
Povidone iodine is iodophor, used as topical antiseptic in surgery and for skin and mucous membrane infections, also as aerosol. A 10% povidone iodine solution contains 1% available iodine, but free-iodine is at 0.1% concentration. Skin exposure causes irritant rather than allergic contact dermatitis. In such a situation, however, iodine seems to be the true hapten.
来歴
Povidone iodine (PI) is frequently used during surgical preparation, postoperative wound cleaning and dressing. It was described by Shelaski about seventy years ago (Shelanski and Shelanski, 1956). PI consists of the complex structure of povidone, a polymer that is structurally similar to plasma proteins, and the iodine element, which has antimicrobial properties. The function of polyvinylpyrrolidone (PVP) used as a polymer includes increasing iodine solubility and penetration, decreasing iodine ion concentration and keeping iodine bound. However, PVP does not have antimicrobial properties. Shelanski defined this complex structure as 'iodophor' (Shelanski and Shelanski, 1956).
製法・合成法
製造方法
Povidone Iodine Solution is an antiseptic and disinfectant agent. The preparation method of povidone iodine: be that 1.17% potassium iodide is dissolved in part water in 10% water by mass percent, 2.34% iodine is added to wherein stirring and dissolving, be mixed with iodine solution standby; 0.01% stability auxiliary agent is dissolved in part water 10% water standby; In complex reaction still, add remaining water, open and stir, dropping into 10.0% polyvinylpyrrolidone k30 dissolves, then substep adds above-mentioned two kinds of solution that prepare, finally add 7.5% solvent normal propyl alcohol, after feeding intake, allow reactant mixture at 20 ℃, react 2 hours, react complete mixture is lowered the temperature and obtained betagen solution.