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O-メチルヒドロキシルアミン
(アミノオキシ)メタン · メトキシアミン · O-メチルヒドロキシルアミン · Ｏメチルヒドロキシルアミン · Methoxyamine · NCI-C-60060 · (Aminooxy)methane · Relugoli Impurity 94
識別子と物理属性
| CAS No. | 67-62-9 |
|---|---|
| 分子式 | CH5NO |
| 平均分子量 | 47.057 g/mol |
| 単同位体質量 | 47.03711378 g/mol |
| SMILES | CON |
| InChIKey | GMPKIPWJBDOURN-UHFFFAOYSA-N |
| PubChem CID | 4113 |
| ChEMBL | CHEMBL1213633 |
| ChEBI | CHEBI:192842 |
| EC No. | 200-660-1 |
| DTXSID | DTXSID8043862 |
| 現地名 | O-メチルヒドロキシルアミン |
化学・物理的性質
| XLogP | -0.7 |
|---|---|
| 極性表面積 | 35.3 |
| 水素結合供与体数 | 1 |
| 水素結合受容体数 | 2 |
| 回転可能結合数 | 0 |
| 重原子数 | 3 |
| 形式電荷 | 0 |
| 複雑度 | 4.8 |
| 物質分類 | Nitrogen Compounds -> Hydroxylamines |
| SpringerMaterials Properties | Schoenflies notation |
| 臭い | FISHY, AMINE ODOR |
| Color/Form | MOBILE LIQUID |
| 溶解度 | SLIGHTLY SOL IN BENZENE, PETROLEUM ETHER /N-METHYLHYDROXYLAMINE/MISCIBLE WITH WATER, ALCOHOL, ETHER |
| 沸点 | 49-50 °C @ 760 MM HG47.83°C |
| 蒸気圧 | 291.0 [mmHg] |
| Physical Description | Colorless liquid with an unpleasant odor[Hawley] |
| Other Experimental Properties | INDEX OF REFRACTION: 1.4164 @ 20 °C/DMELTING POINT: 42 °C WITH RAPID HEATINGDENSITY: 1.0003 G/ML @ 20 °C/4 °C /N-METHYLHYDROXYLAMINE/ |
| 融点 | 25°C |
| 密度 | 0.9069 g/cm3 |
| 屈折率 | 1.4164 (estimate) |
| pKa（酸解離定数） | 12.5(at 25℃) |
化学的特性
Colorless liquid; unpleasant odor.Soluble in water and alcohol.
安全性と法規制
| GHS 分類 | DangerH302+H312+H332 (96.6%): Harmful if swallowed, in contact with skin or if inhaled [Warning Acute toxicity, oralacute toxicity, dermalacute toxicity, inhalation]P260, P261, P264, P264+P265, P270, P271, P280, P301+P317, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P354+P338, P316, P317, P321, P330, P362+P364, P363, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 29 reports by companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. |
|---|---|
| 有害性の概要 | Highly irritating[Merck Index] A strong skin irritant[Hawley] Emergency treatment: Corrosives-alkaline[HSDB] Mutagenic[RTECS] See Hydroxylamine. |
| Hazard Classes and Categories | Acute Tox. 4 (100%) |
| Skin, Eye, and Respiratory Irritations | ...CORROSIVE TO SKIN & HIGHLY IRRITANT TO EYES & MUCOUS MEMBRANES... /HYDROXYLAMINE/ |
| 有害作用 | Dermatotoxin - Skin burns. |
| Human Toxicity Excerpts | ...CORROSIVE TO SKIN & HIGHLY IRRITANT TO EYES & MUCOUS MEMBRANES. REPEATED EXPOSURE MAY ENHANCE ALLERGIC REACTION PARTICULARLY OF BACK OF HANDS & FOREARMS FROM 1-2 WK TO 2-5 YR AFTER COMMENCEMENT OF EXPOSURE & CASES OF ECZEMA...FOLLOWING PROLONGED CONTACT. ... NO CASES OF SYSTEMIC POISONING...IN WORKERS. /HYDROXYLAMINE//HYDROXYLAMINE IS/ ABOUT EQUIPOTENT TO NITRITE AS METHEMOGLOBIN FORMER, BUT IT HAS GREATER TENDENCY TO PRODUCE SULFHEMOGLOBIN, HEINZ BODIES & OTHER IRREVERSIBLE RED CELL DAMAGE. ... SYSTEMIC POISONING CHARACTERIZED BY CYANOSIS, CONVULSIONS & COMA. /HYDROXYLAMINE/ |
| Non-Human Toxicity Excerpts | /HIGH CONCN/ IN ANIMALS...CAUSES CONVULSIONS FOLLOWED BY PARALYSIS & DEATH FROM CESSATION OF BREATHING... CHRONIC ABSORPTION OF MODERATE DOSES (1 MG/KG) MAY LEAD TO SLIGHT ANEMIA. /HYDROXYLAMINE/...INHIBITOR OF CATALASE &...WHEN ADMIN PARENTERALLY, 40 MG CAUSING CONVULSIONS, NYSTAGMUS & DEATH IN RABBIT. LOCAL APPLICATION OF 10% SOLN...TO RABBIT EYES...CAUSED MODERATE INFLAMMATION OF CONJUNCTIVA. /HYDROXYLAMINE/HYDROXYLAMINE ELEVATES BRAIN GABA /GAMMA-AMINOBUTYRIC ACID/ LEVELS IN RATS. /HYDROXYLAMINE/O-METHYLHYDROXYLAMINE (2000 MCG/ML) INDUCED RESISTANCE MUTATION TO 8-AZAGUANINE. IT IS HIGHLY POTENT MUTAGEN FOR MICROORGANISMS AS WELL AS FOR MAMMALIAN CELLS.REPLICATION OF PHAGE MS2 IN PRESENCE OF O-METHYLHYDROXYLAMINE (MUTAGENESIS IN VIVO) INCR REVERSION FREQUENCY OF 2 AMBER MUTATIONS IN MATURATION PROTEIN. PROBABLE MODE OF MUTAGENIC ACTION INVOLVES ENZYMATIC FORMATION OF MODIFIED PRECURSORS & INCORPORATION INTO RNA. |
| 輸送番号（UN） | 1760 |
| 危険等級 | 8 |
| 包装等級 | II |
| 有害物質データ | 67-62-9(Hazardous Substances Data) |
用途
使用
Analytical reagent, mainly for ketones and aldehydes.