基本情報
- CAS
127502-06-1- 標準SMILES
CCOCCP(CCOCC)CCP(CCOCC)CCOCC- InChIKey
QCWJONLQSHEGEJ-UHFFFAOYSA-N- 分子式
- C18H40O4P2
- 平均分子量
- 382.5 g/mol
- 単同位体質量
- 382.24018375
概要
Tetrofosmin is a phosphine.
名称と識別子
- 優先名称
- Tetrofosmin
- IUPAC
- 2-[bis(2-ethoxyethyl)phosphanyl]ethyl-bis(2-ethoxyethyl)phosphane
- 現地名
- テトロホスミン
- 英語名
- Tetrofosmin
- 分子式
- C18H40O4P2
- 分子量
- 382.46
名称と別名
TetrofosminUNII-3J0KPB596QtetrofosmineTetrofosmina3J0KPB596QP 53P-53DTXSID70155591TETROFOSMIN (II)TETROFOSMIN [II]tetrofosminumRefChem:58134
名称をさらに表示
テトロホスミンテトロホスミン (JAN)エチレンビス[ビス(2-エトキシエチル)ホスフィン]6,9-ビス(2-エトキシエチル)-3,12-ジオキサ-6,9-ジホスファテトラデカンテトロフォスミン1,2-ビス[ビス(2-エトキシエチル)ホスフィノ]エタンMyoview
DTXCID5078082V09GA02127502-06-1ethylenebis[bis(2-ethoxyethyl)phosphine]2-[bis(2-ethoxyethyl)phosphanyl]ethyl-bis(2-ethoxyethyl)phosphane3,12-Dioxa-6,9-diphosphatetradecane, 6,9-bis(2-ethoxyethyl)-Tetrofosmin [USAN:INN:BAN:JAN]6,9-bis(2-ethoxyethyl)-3,12-dioxa-6,9-diphosphatetradecane
データベース識別子
- CAS
127502-06-1- PubChem CID
- 4274
- DTXSID
DTXSID70155591- ChEMBL
CHEMBL1615784- ChEBI
CHEBI:135598- UNII
- 3J0KPB596Q
- Nikkaji
- J506.542I
物性
構造計算による物性
- XLogP
- 0.5
- 極性表面積
- 36.9 Ų
- 水素結合供与体数
- 0
- 水素結合受容体数
- 4
- 回転可能結合数
- 19
- 重原子数
- 24
- 形式電荷
- 0
- 複雑度
- 201
実験および物理化学的性質
DrugsPharmaceuticals -> Listed in ZINC15
SolubilitySoluble
Boiling Point100ºC
物理化学的性質
- 沸点
- 447.1 · 447.1±45.0 °C(Predicted)
化学と産業
薬理情報
Protein BindingRefer to [DB09160]
PharmacodynamicsRefer to [DB09160]
Mechanism of Action
Tetrofosmin normal biodistribution makes it suitable to be used as a myocardial agent as it is uptaken by the myocardial tissue and it presents a very low redistribution after 3-4 hours of administration. After distribution, tetrofosmin is a lipophilic cationic agent which is passively diffused and accumulated in viable myocardial tissue.
Biological Half-LifeRefer to [DB09160]
Metabolism/MetabolitesThis pharmacokinetic property has not been fully studied.
Absorption, Distribution and Excretion
After intravenous administration, tetrofosmin is rapidly cleared from the blood and taken up by the heart, skeletal muscle, liver, spleen and kidneys.
Refer to [DB09160]
This pharmacokinetic property has not been fully studied.
Refer to [DB09160]
応用分野
使用Tetrofosmin is used in diagnostic imaging procedures. A dual tracer imager for patients with hyperparathyroidism. A radiotracers for SPECT imaging.
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