N,N,N',N'-Tetramethylazodicarboxamide (HCID 4278)

名称と識別子

優先名称: N,N,N',N'-Tetramethylazodicarboxamide
IUPAC: 3-(dimethylcarbamoylimino)-1,1-dimethylurea
現地名: 1,1'-アゾビス(N,N-ジメチルホルムアミド)
英語名: N,N,N',N'-Tetramethylazodicarboxamide
分子式: C6H12N4O2
分子量: 172.19

名称と別名

10465-78-8N,N,N',N'-TetramethylazodicarboxamideDTXSID6040456CHEBI:48958RefChem:1090319DTXCID40204561,1'-azobis(N,N-dimethylformamide)N1,N1,N2,N2-Tetramethyldiazene-1,2-dicarboxamideMFCD000083181,1'-azobis(N,N'-dimethylformamide)(3E)-3-(dimethylcarbamoylimino)-1,1-dimethyl-ureaN,N,N',N'-Tetramethylazodicarboxamide(TMAD)

名称をさらに表示

1,1'-アゾビス(N,N-ジメチルホルムアミド)N,N,N',N'-テトラメチルジアゼン-1,2-ジカルボアミドN,N,N',N'-テトラメチルジアゼンジカルボアミドアゾビス(N,N-ジメチルホルムアミド)ジアミドダイアマイドN,N,N',N'-テトラメチルアゾジカルボン酸アミドN,N,N',N'-テトラメチルアゾジカルボキサミドビス(ジメチルカルバモイル)ジアゼンN,N,N′,N′-テトラメチルジアゼン-1,2-ジカルボアミド1-[(ジメチルカルバモイル)イミノ]-3,3-ジメチル尿素N,N,N′,N′-テトラメチルジアゼンビスカルボアミドN,N,N′,N′-テトラメチルジアゼンジカルボアミド1,1′-アゾビス(N,N-ジメチルホルムアミド)TMADDIAMIDE(E)-1-[(dimethylcarbamoyl)imino]-3,3-dimethylurea(E)-N1,N1,N2,N2-tetramethyldiazene-1,2-dicarboxamide3-(Dimethylcarbamoylimino)-1,1-dimethylureaNsc143013

C6H12N4O2TetramethylazodicarboxamideN,N',N'-TetramethylazodicarboxamideLopac0_000397SCHEMBL39340MLS002153343SCHEMBL103289orb1219154

データベース識別子

CAS: 10465-78-8
PubChem CID: 4278
DTXSID: DTXSID6040456
ChEMBL: CHEMBL1338900
EC Number: 233-951-7

物性

構造計算による物性

XLogP: 0.2
極性表面積: 65.3 Å²
水素結合供与体数: 0
水素結合受容体数: 2
回転可能結合数: 0
重原子数: 12
形式電荷: 0
複雑度: 188

実験および物理化学的性質

Chemical ClassesOther Uses -> Biochemical Research

Physical DescriptionYellow crystalline solid; [Sigma-Aldrich MSDS]

物理化学的性質

融点: 112 °C · 112 °C
沸点: 220.4 · 220.4±23.0 °C(Predicted)
比重(密度): 1.13 · 1.13±0.1 g/cm3(Predicted)
貯蔵温度: -20 °C · -20°C
溶解性: soluble in Methanol
外見: 結晶性
酸解離定数(Pka): 0 · -0+-.0.70(Predicted)
色: 黄色
水溶解度: 19.6 · water: 19.60-21.00mg/mL, clear to slightly hazy, orange
BRN: 1910409 · 1910409
InChI: InChI=1S/C6H12N4O2/c1-9(2)5(11)7-8-6(12)10(3)4/h1-4H3/b8-7+
InChIKey: VLSDXINSOMDCBK-BQYQJAHWSA-N
SMILES: C(=O)(/N=N/C(=O)N(C)C)N(C)C
CAS データベース: 10465 · 10465-78-8(CAS DataBase Reference)

化学的性質

化学的特性Yellow crystals

安全と法規制

GHS分類

GHS Classification · 5 件

This chemical does not meet GHS hazard criteria for 50% (2 of 4) of reports.

Warning

H315 (50%): Causes skin irritation [Warning Skin corrosion/irritation]

P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 4 reports by companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

危険有害性情報

Regulatory InformationStatus: Active Update: 29-07-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/29433

Hazards SummaryMay cause irritation; [Sigma-Aldrich MSDS]

Hazard Classes and CategoriesSkin Irrit. 2 (50%)

安全データ

F: 4.10
wgk: 3
rtecs: LQ1041000
hs_code: 29270000
消防法: 危-5-II
safety_code: 22-24/25
ストレージクラス: 11 - Combustible Solids

化学と産業

用途と製造

UsesA sulfhydryl reagent which oxidizes sulfhydryl groups to the disulfide form. It is a radiation-sensitizing agent of anoxic bacterial and mammalian cells. [ChemIDplus]

応用分野 · 1 件

使用Reported to be of use as a thiol oxidizing agent. Diamide has been used to titrate protein glutathiolation to discriminate from other oxidative protein modifications. Treatment increased protein glutathiolation in a concentration-dependent manner and had comparably little effect on protein-protein disulfide formation.