beta-D-Galactopyranose

Powder; [Sigma-Aldrich MSDS]

Solid

Danger

H334 (99.9%): May cause allergy or asthma symptoms or breathing difficulties if inhaled [Danger Sensitization, respiratory]

P233, P260, P271, P284, P304+P340, P342+P316, P403, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 1506 reports by companies from 4 notifications to the ECHA C&L Inventory.；Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

Chemical: Galactosidase, .beta.-

Galactosidase, .beta.-: Does not have an individual approval but may be used under an appropriate group standard

.beta.-D-Galactopyranose: Does not have an individual approval but may be used under an appropriate group standard

Chemical: Galactosidase, .beta.-

Galactosidase, .beta.-: Does not have an individual approval but may be used under an appropriate group standard

.beta.-D-Galactopyranose: Does not have an individual approval but may be used under an appropriate group standard

A - Alimentary tract and metabolism；A09 - Digestives, incl. enzymes；A09A - Digestives, incl. enzymes；A09AA - Enzyme preparations；A09AA04 - Tilactase

QA - Alimentary tract and metabolism；QA09 - Digestives, incl. enzymes；QA09A - Digestives, incl. enzymes；QA09AA - Enzyme preparations；QA09AA04 - Tilactase

The use of a single oral administration of tilactase has been shown to be highly effective in decreasing the symptoms and hydrogen excretion of hypolactasia in tests of lactose H(2)-breath. The analysis has shown a decrease of approximately 80% in both malabsorbers and intolerants.The administration of tilacatase also decreases the presence of bloating and flatus.

Lactose is the primary disaccharide found in dairy products. Tilactase is a type of lactase which is the enzyme that is in charge of the breakdown of lactose to glucose and galactose which can be used by the body. Basically, tilactase acts by replacing the missing lactase in the body and allows avoidance of the reach of lactose to the small intestine and the normal bacteria and thus, preventing the symptoms of the lactose intolerance. Once tilactase has metabolized the lactose, the metabolism products are reabsorbed by the normal process of digestion.

Tilactase is not absorbed in the GI tract and thus the pharmacokinetic parameters related to absorption are not relevant.

Tilactase is completely eliminated in the feces either unchanged or as metabolites.

Tilactase is not absorbed and thus the volume of distribution is not relevant.

Tilactase is not absorbed and thus the clearance rate is not relevant.

A group of enzymes that catalyzes the hydrolysis of terminal, non-reducing beta-D-galactose residues in beta-galactosides. Deficiency of beta-Galactosidase A1 may cause GANGLIOSIDOSIS, GM1. [ChemIDplus] Available commercially as a catalyst to hydrolyze milk lactose into glucose and galactose; [REPROTOX]