基本情報
- CAS
135467-16-2- 標準SMILES
C[C@@H](O)[C@@H]1NC(=O)[C@H](CCCCN)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)[C@H](N)Cc2ccccc2)CSSC[C@@H](C(=O)N[C@H](CO)[C@@H](C)O)NC1=O.O=C(O)c1cc2ccccc2c(Cc2c(O)c(C(=O)O)cc3ccccc23)c1O- InChIKey
KFWJVABDRRDUHY-XJQYZYIXSA-N- 分子式
- C72H82N10O16S2
- 平均分子量
- 1,407.6 g/mol
概要
Octreotide Pamoate is a synthetic long-acting octapeptide analogue of endogenous somatostatin. Octreotide pamoate binds to somatostatin receptors expressed by some neuroendocrine and non-neuroendocrine tumor cells, thereby initiating somatostatin receptor-mediated apoptosis. Other possible antineoplastic activities of this agent include suppression of tumor angiogenesis and tumor growth-promoting insulin-like growth factor 1 (IGF-1). (NCI04)
名称と識別子
- 優先名称
- Octreotide pamoate
- IUPAC
- (4R,7S,10S,13R,16S,19R)-10-(4-aminobutyl)-19-[[(2R)-2-amino-3-phenylpropanoyl]amino]-16-benzyl-N-[(2R,3R)-1,3-dihydroxybutan-2-yl]-7-[(1R)-1-hydroxyethyl]-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxamide;4-[(3-carboxy-2-hydroxynaphthalen-1-yl)methyl]-3-hydroxynaphthalene-2-carboxylic acid
- 現地名
- パモ酸オクトレオチド
- 英語名
- SMS 201-995 pa
- 分子式
- C72H82N10O16S2
- 分子量
- 1407.62
名称と別名
Octreotide pamoateSMS paOctreotide embonateSMS-PAMWH8YQ1AIOSMS 201-995 paOctreotide pamoate [USAN]UNII-MWH8YQ1AIOSMS-201-995 PA135467-16-2OCTREOTIDE EMBONATE [WHO-DD]Octreotide pamoate (USAN)
名称をさらに表示
パモ酸オクトレオチド
D-PHENYLALANYL-L-CYSTEINYL-L-PHENYLALANYL-D-TRYPTOPHYL-L-LYSYL-L-THREONYL-L-CYSTEINYL-L-THREONINOL CYCLIC (2->7)-DISULFIDE EMBONATE (1:1) (SALT)D-PHENYLALANYL-L-CYSTEINYL-L-PHENYLALANYL-D-TRYPTOPHYL-L-LYSYL-L-THREONYL-L-CYSTEINYL-L-THREONINOL CYCLIC (2->7)-DISULFIDE PAMOATE (1:1) (SALT)D-PHENYLALANYL-L-CYSTEINYL-L-PHENYLALANYL-D-TRYPTOPHYL-L-LYSYL-L-THREONYL-L-CYSTEINYL-L-THREONINOL CYCLIC (2->7)-DISULPHIDE PAMOATE (1:1) (SALT)D-PHENYLALANYL-L-CYSTEINYL-L-PHENYLALANYL-D-TRYPTOPHYL-L-LYSYL-L-THREONYL-N-((1R,2R)-2-HYDROXY-1-(HYDROXYMETHYL)PROPYL)-L-CYSTEINAMIDE CYCLIC (2->7)-DISULFIDE 4,4'-METHYLENEBIS(3-HYDROXY-2-NAPHTHOATE) (1:1) (SALT)D-PHENYLALANYL-L-CYSTEINYL-L-PHENYLALANYL-D-TRYPTOPHYL-L-LYSYL-L-THREONYL-N-((1R,2R)-2-HYDROXY-1-(HYDROXYMETHYL)PROPYL)-L-CYSTEINAMIDE CYCLIC (2->7)-DISULPHIDE 4,4'-METHYLENEBIS(3-HYDROXY-2-NAPHTHOATE) (1:1) (SALT)L-CYSTEINAMIDE, D-PHENYLALANYL-L-CYSTEINYL-L-PHENYLALANYL-D-TRYPTOPHYL-L-LYSYL-L-THREONYL-N-(2-HYDROXY-1-(HYDROXYMETHYL)PROPYL)-, CYCLIC (2->7)-DISULFIDE (R-(R*,R*))-, 4,4'-METHYLENEBIS(3-HYDROXY-2-NAPHTHALENECARBOXYLATE) (1:1) (SALT)L-CYSTEINAMIDE, D-PHENYLALANYL-L-CYSTEINYL-L-PHENYLALANYL-D-TRYPTOPHYL-L-LYSYL-L-THREONYL-N-(2-HYDROXY-1-(HYDROXYMETHYL)PROPYL)-, CYCLIC (2->7)-DISULPHIDE (R-(R*,R*))-, 4,4'-METHYLENEBIS(3-HYDROXY-2-NAPHTHALENECARBOXYLATE) (1:1) (SALT)RefChem:167859
物性
構造計算による物性
- 極性表面積
- 498 Ų
- 水素結合供与体数
- 17
- 水素結合受容体数
- 20
- 回転可能結合数
- 21
- 重原子数
- 100
- 形式電荷
- 0
- 複雑度
- 2,310
化学と産業
応用分野
使用Antineoplastic.
サプライヤー4 社
杭州思诺达医药科技有限责任公司0571-87213919 17306812703 · [email protected]
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杭州肽佳生物科技有限公司0571-87213919 15967184799 · [email protected]
TargetMol中国（陶术生物）15002134094 · [email protected]
関連反応
3 件
化合物ノート
読み込み中…