ロキシスロマイシン

用途薬理作用研究用。

用途マクロライド系抗生物質です。 細菌リボソーム 50s に結合し、タンパク質合 成阻害作用を示します。グラム陽性・陰性菌 に抗菌作用を示します。

用途マクロライド系抗生物質です。 細菌リボソーム 50S に結合し、タンパク質 合成阻害作用を示します。グラム陽性・陰性 菌に抗菌作用を示します。

説明Roxithromycin, an oxime ether derivative of erythromycin, is a new macrolide antibiotic of high potency and long duration. Its in v i m activity spectrum is similar to that of erythromycin, but is superior to the latter against Legionella, Mycoplasma and Chlamydia.

使用Roxithromycin was one of the new generation erythromycins introduced in the 1980s. Improved acid stability was achieved by converting the 9-keto group to the more stable oxime and alkylation of the oxime to provide the methoxyethoxymethyl ether oxime. In vivo, roxithromycin exhibits higher tissue levels and a longer half-life while being slightly less potent than erythromycin in vitro.