基本情報
- CAS
54533-85-6- 標準SMILES
CCN(CC)Cc1nccn1-c1ccc([N+](=O)[O-])cc1C(=O)c1ccccc1Cl- InChIKey
WZGBZLHGOVJDET-UHFFFAOYSA-N- 分子式
- C21H21ClN4O3
- 平均分子量
- 412.9 g/mol
- 単同位体質量
- 412.1302182
概要
Nizofenone is a member of benzophenones.
名称と識別子
- 優先名称
- Nizofenone
- IUPAC
- (2-chlorophenyl)-[2-[2-(diethylaminomethyl)imidazol-1-yl]-5-nitrophenyl]methanone
- 現地名
- ニゾフェノン
- 英語名
- Nizofenone
- 分子式
- C21H21ClN4O3
- 分子量
- 412.87
名称と別名
Nizofenone54533-85-6NizofenonaNizofenonum7A2NOC3R88DTXSID401014745RefChem:166178DTXCID2028563N06BX101-(2-(2-chlorobenzoyl)-4-nitrophenyl)-2-(diethylaminomethyl)imidazole((1-(2-(2-chlorobenzoyl)-4-nitrophenyl)-1H-imidazol-2-yl)methyl)diethylamineNizofenone [INN]
名称をさらに表示
2'-クロロ-2-[2-[(ジエチルアミノ)メチル]-1H-イミダゾール-1-イル]-5-ニトロベンゾフェノン1-[2-(2-クロロベンゾイル)-4-ニトロフェニル]-2-(ジエチルアミノメチル)-1H-イミダゾール(2-クロロフェニル)[2-[2-[(ジエチルアミノ)メチル]-1H-イミダゾール-1-イル]-5-ニトロフェニル]メタノンニゾフェノン2′-クロロ-2-[2-[(ジエチルアミノ)メチル]-1H-イミダゾール-1-イル]-5-ニトロベンゾフェノン({1-[2-(2-クロロベンゾイル)-4-ニトロフェニル]-1H-イミダゾール-2-イル}メチル)ジエチルアミンEkonNY-9179MidafenoneNizofenone fumarateNizofenone USP/EP/BP1-[2-(2-Chlorobenzoyl)-4-nitrophenyl]-2-(diethylaminomethyl)-1H-imidazole2'-Chloro-2-[2-[(diethylamino)methyl]-1H-imidazol-1-yl]-5-nitrobenzophenone(2-chlorophenyl)-[2-[2-(diethylaminomethyl)-1-imidazolyl]-5-nitrophenyl]methanone
物性
構造計算による物性
- XLogP
- 4.1
- 極性表面積
- 84 Ų
- 水素結合供与体数
- 0
- 水素結合受容体数
- 5
- 回転可能結合数
- 7
- 重原子数
- 29
- 形式電荷
- 0
- 複雑度
- 569
物理化学的性質
- 融点
- 75 · 75-76°
- 沸点
- 609.7 · 609.7±65.0 °C(Predicted)
- 比重(密度)
- 1.28 · 1.28±0.1 g/cm3(Predicted)
- 貯蔵温度
- 2 · 2-8°C
- 酸解離定数(Pka)
- 8.75 · 8.75±0.25(Predicted)
化学と産業
薬理情報
ATC Code
N - Nervous system
QN - Nervous system
MeSH Pharmacological Classification
Agents used for the treatment or prevention of cardiac arrhythmias. They may affect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers. Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade.
Drugs intended to prevent damage to the brain or spinal cord from ischemia, stroke, convulsions, or trauma. Some must be administered before the event, but others may be effective for some time after. They act by a variety of mechanisms, but often directly or indirectly minimize the damage produced by endogenous excitatory amino acids.
応用分野
説明Nizofenzone fumarate is a potent antianoxic agent reported of benefit to geriatric and stroke patients. In animal models nizofenzone is reported to have protective effects against anoxia, global ischemia or other conditions resulting from cerebral infarction. It is also claimed to be a sedative and anticonvulsant.
上流・下流製品情報
上流原料
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