ヘミン

化学的特性Hemin is a Dark purple crystalline powder or elongated needle-shaped crystal. It does not dissolve in water, but it can dissolve in acidic acetone and alkaline water. The molecular formula is C34H32ClFe(III)N4O4, and the molecular weight is 651.96. Hemin is mainly used as raw material for anti-anemia and anti-cancer drugs.

解説ferriprotoporphyrin chlorid．C34H32ClFeN4O4(651.96)．クロロヘミンともいう．Cl原子が1個配位したポルフィリンの三価鉄錯体の慣用名．ヘミンは，塩化ストロンチウムを溶解した氷酢酸-アセトン混合液に血液を加え，濾液を濃縮して析出させると得られる．長方形板状晶．融点300 ℃ 以上．希アンモニア水に易溶，希酸，水に難溶．240 ℃ で昇華する．アルカリ溶液中では塩素がヒドロキシ基と置換したヘマチンになり，濃硫酸に溶解すると鉄を失う．森北出版「化学辞典（第2版）

用途希少疾病用医薬品急性ポルフィリン症の発作の治療

説明Hemin is a metalloporphyrin compound with a relatively simple structure. It is formed by the complexation of a molecule of ferrous iron and protoporphyrin. It is an in vitro group substitute of natural heme and its chemical properties are similar to that of heme. Heme, an essential small molecule in living organisms, can be found abundantly in various organisms including animals, plants, microorganisms, and algae.

使用Hemin is used in cellular protection and control mechanism. It stimulates the synthesis of globulin. It is also used to study the bacterial strains and growth conditions, in the short-term colony assays and cell transfections. Further, it is used to treat the symptoms of various porphyrias. In addition, it is used in the preparation of agar medium for the bacteria culture.

一般的な説明Heme is a small molecule present either free or bound to hemoglobin in the bloodstream of mammals. This is an alternative source of iron within the host that contains a porphyrin ring containing a Fe2+ ion called hemin.

使用用途ヘミンはヘモグロビンといった血液への活性に関わる分野で、医薬の中間体として使われています。ヘミンは医療において、赤血球系の細胞の「分化誘導」活性を有することがわかっていました。 ヘミン自体が化学式の示す通り、塩素イオンを1つ有するポルフィリンの3価鉄錯体です。血液中のヘモグロビンを作るのに重要な鉄分と相関があります。そのため、人体に対して早くから貢献していた物質と言えます。

純化方法Hemin is purified by recrystallisation from AcOH. Also, hemin (5g) is shaken in pyridine (25mL) till it dissolves, then CHCl3 (40mL) is added, the container is stoppered and shaken for 5minutes (releasing the stopper occasionally). The solution is filtered under slight suction, and the flask and filter are washed with a little CHCl3 (15mL). During this period, AcOH (300mL) is heated to boiling, and saturated aqueous NaCl (5mL) and conc HCl (4mL) are added. The CHCl3 filtrate is poured in a steady stream, with stirring, into the hot AcOH mixture and set aside for 12hours. The crystals are filtered off, washed with 50% aqueous AcOH (50mL), H2O (100mL), EtOH (25mL), Et2O and dried in air. [Fischer Org Synth Coll Vol III 442 1955, Beilstein 26 III/IV 3048.]