Levovirin

HCID 460516

ノート反応

部分構造検索類似構造を探す

基本情報

CAS: 206269-27-4
標準SMILES: NC(=O)c1ncn([C@H]2O[C@@H](CO)[C@H](O)[C@@H]2O)n1
InChIKey: IWUCXVSUMQZMFG-RGDLXGNYSA-N
分子式: C8H12N4O5
平均分子量: 244.2 g/mol
単同位体質量: 244.08076948

名称と識別子

優先名称: Levovirin
IUPAC: 1-[(2S,3S,4R,5S)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2,4-triazole-3-carboxamide
英語名: 1-[(2S,3S,4S,5S)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2,4-triazole-3-carboxamide
分子式: C8H12N4O5
分子量: 244.2

名称と別名

Levovirin206269-27-4L-RibavirinICN17261ICN 17261UNII-ZGF0S6S33QZGF0S6S33QICN-17261LEVOVIRIN [WHO-DD]DTXSID901746481H-1,2,4-Triazole-3-carboxamide, 1-beta-L-ribofuranosyl-1H-1,2,4-TRIAZOLE-3-CARBOXAMIDE, 1-BETA;-L-RIBOFURANOSYL-

名称をさらに表示

L-Ribovirin1-β-L-ribofuranosyl-1,2,4-triazole-3-carboxamide1H-1,2,4-Triazole-3-carboxamide, 1-β-L-ribofuranosyl-1-[(2S,3S,4R,5S)-3,4-dihydroxy-5-methylol-tetrahydrofuran-2-yl]-1,2,4-triazole-3-carboxamide

1-[(2S,3S,4R,5S)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1H-1,2,4-triazole-3-carboxamide1-((2S,3S,4R,5S)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl)-1H-1,2,4-triazole-3-carboxamideRefChem:153236DTXCID30971391-((2S,3S,4R,5S)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1H-1,2,4-triazole-3-carboxamide1-[(2S,3S,4R,5S)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2,4-triazole-3-carboxamide1-beta-l-ribofuranosyl-1h-1,2,4-triazole-3-carboxamide1-[(2S,3S,4S,5S)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2,4-triazole-3-carboxamide

データベース識別子

CAS: 206269-27-4
PubChem CID: 460516
DTXSID: DTXSID90174648
ChEMBL: CHEMBL274536
UNII: ZGF0S6S33Q
Nikkaji: J1.303.803A

物性

構造計算による物性

XLogP: -1.8
極性表面積: 144 Å²
水素結合供与体数: 4
水素結合受容体数: 7
回転可能結合数: 3
重原子数: 17
形式電荷: 0
複雑度: 304

実験および物理化学的性質

DrugsPharmaceuticals -> Listed in ZINC15

物理化学的性質

溶解性: DMSO (Slightly), Methanol (Slightly, Heated, Sonicated), Water (Slightly)
外見: Solid
色: White to Off-White
安定性: Hygroscopic

化学と産業

応用分野

使用Levovirin is a monocyclic L-nucleosides with type 1 cytokine-inducing activity. Levovirin is the L-enantiomer of Ribavirin (R414475) with similar immunomodulatory activity but does not have direct antiviral activity or hemolytic anemia.