化工社化工社 化学情報印刷レポート · 研究参考用
オキサゾラム
ネブスン · オキサゾラム · 10-クロロ-2,3,7,11b-テトラヒドロ-2-メチル-11b-フェニルオキサゾロ[3,2-d][1,4]ベンゾジアゼピン-6(5H)-オン · ペルサール · セレナール · トッカータ · セレナル【日本】 · オキサゾラム (JP17)
識別子と物理属性
| CAS No. | 24143-17-7 |
|---|---|
| 分子式 | C18H17ClN2O2 |
| 平均分子量 | 328.8 g/mol |
| 単同位体質量 | 328.0978555 g/mol |
| SMILES | CC1CN2CC(=O)Nc3ccc(Cl)cc3C2(c2ccccc2)O1 |
| InChIKey | VCCZBYPHZRWKFY-UHFFFAOYSA-N |
| PubChem CID | 4617 |
| ChEMBL | CHEMBL2104805 |
| ChEBI | CHEBI:31944 |
| EC No. | 246-032-0 |
| DTXSID | DTXSID5023401 |
| 現地名 | オキサゾラム |
化学・物理的性質
| XLogP | 3 |
|---|---|
| 極性表面積 | 41.6 |
| 水素結合供与体数 | 1 |
| 水素結合受容体数 | 3 |
| 回転可能結合数 | 1 |
| 重原子数 | 23 |
| 形式電荷 | 0 |
| 複雑度 | 468 |
| Kovats Retention Index | 25642569258625962590 |
| 融点 | 187°C |
| 沸点 | 495.8±45.0 °C(Predicted) |
| 密度 | 1.2065 (rough estimate) |
| 屈折率 | 1.5400 (estimate) |
| 引火点 | 11 °C |
| 貯蔵条件 | 2-8°C |
| 溶解度 | Chloroform (Slightly), Methanol (Slightly) |
| pKa（酸解離定数） | 12.85±0.60(Predicted) |
| 外観・状態 | 固体 |
安全性と法規制
| GHS 分類 | DangerH301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]H331 (100%): Toxic if inhaled [Danger Acute toxicity, inhalation]P261, P264, P264+P265, P270, P271, P280, P301+P316, P302+P352, P304+P340, P305+P351+P338, P316, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 39 reports by companies from 1 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. |
|---|---|
| 規制情報 | DEA schedule IV controlled substance |
| Hazard Classes and Categories | Acute Tox. 3 (100%)Skin Irrit. 2 (100%)Eye Irrit. 2 (100%) |
| Treatment | General supportive measures should be employed, along with intravenous fluids, and an adequate airway maintained. Hypotension may be combated by the use of norepinephrine or metaraminol. Dialysis is of limited value. Flumazenil (Anexate) is a competitive benzodiazepine receptor antagonist that can be used as an antidote for benzodiazepine overdose. In particular, flumazenil is very effective at reversing the CNS depression associated with benzodiazepines but is less effective at reversing respiratory depression. Its use, however, is controversial as it has numerous contraindications. It is contraindicated in patients who are on long-term benzodiazepines, those who have ingested a substance that lowers the seizure threshold, or in patients who have tachycardia or a history of seizures. As a general rule, medical observation and supportive care are the mainstay of treatment of benzodiazepine overdose. Although benzodiazepines are absorbed by activated charcoal, gastric decontamination with activated charcoal is not beneficial in pure benzodiazepine overdose as the risk of adverse effects often outweigh any potential benefit from the procedure. It is recommended only if benzodiazepines have been taken in combination with other drugs that may benefit from decontamination. Gastric lavage (stomach pumping) or whole bowel irrigation are also not recommended. |
用途
解説
オキサゾラム．N-(2-ベンゾイル-4-クロロフェニル)ブロモアセトアミドと1-アミノ-2-プロパノールとを加熱反応させると得られる．白色の結晶性粉末．融点約187 ℃．酢酸に易溶，1,4-ジオキサン，ジクロロメタンに可溶，エタノール，エーテルに難溶，水に不溶．トランキライザーとして用いられる．LD50 5200 mg/kg(マウス，経口)．
用途
ベンゾジアゼピン系化合物で す。GABA受容体に作用し、中枢神経抑制作 用を示します。作用時間は、長時間型とされ ています。
用途
ベンゾジアゼピン系化合物で す。GABA 受容体に作用し、中枢神経抑制作 用を示します。作用時間は、長時間型とされ ています。
使用
A psychotropic agent with anxiolytic, anticonvulsant, sedative and skeletal muscle relaxant properties. It is a precursor to the active substance Desmethyldiazepam (D291595).