基本情報
- CAS
1228559-81-6- 標準SMILES
Cc1cccc(C)c1CNc1cc(C(=O)NCCOC(=O)CCCC(=O)O)cn2c(C)c(C)nc12- InChIKey
GPHPBXRKAJSSIC-UHFFFAOYSA-N- 分子式
- C26H32N4O5
- 平均分子量
- 480.6 g/mol
- 単同位体質量
- 480.23727013
概要
Linaprazan glurate is a small molecule drug. The usage of the INN stem '-prazan' in the name indicates that Linaprazan glurate is a proton pump inhibitor, not dependent on acid activation. Linaprazan glurate is under investigation in clinical trial NCT07037875 (A Study Comparing the Effect and Safety of Linaprazan Glurate to Lansoprazole in Participants With Erosive Esophagitis (EE) Due to Gastroesophageal Reflux Disease (GERD)). Linaprazan glurate has a monoisotopic molecular weight of 480.24 Da.
名称と識別子
- 優先名称
- Linaprazan Glurate
- IUPAC
- 5-[2-[[8-[(2,6-dimethylphenyl)methylamino]-2,3-dimethylimidazo[1,2-a]pyridine-6-carbonyl]amino]ethoxy]-5-oxopentanoic acid
- 英語名
- Pentanedioic acid, 1-[2-[[[8-[[(2,6-dimethylphenyl)methyl]amino]-2,3-dimethylimidazo[1,2-a]pyridin-6-yl]carbonyl]amino]ethyl] ester
- 分子式
- C26H32N4O5
- 分子量
- 480.56
名称と別名
Linaprazan glurate1228559-81-6Linaprazan glurate [INN]3VG4D399DT1-(2-(((8-(((2,6-Dimethylphenyl)methyl)amino)-2,3-dimethylimidazo(1,2-a)pyridin-6-yl)carbonyl)amino)ethyl) pentanedioatePentanedioic acid, 1-(2-(((8-(((2,6-dimethylphenyl)methyl)amino)-2,3-dimethylimidazo(1,2-a)pyridin-6-yl)carbonyl)amino)ethyl) ester1-[2-[[[8-[[(2,6-Dimethylphenyl)methyl]amino]-2,3-dimethylimidazo[1,2-a]pyridin-6-yl]carbonyl]amino]ethyl] pentanedioatePentanedioic acid, 1-[2-[[[8-[[(2,6-dimethylphenyl)methyl]amino]-2,3-dimethylimidazo[1,2-a]pyridin-6-yl]carbonyl]amino]ethyl] esterRefChem:153490UNII-3VG4D399DT5-(2-(8-((2,6-Dimethylbenzyl)amino)-2,3-dimethylimidazo[1,2-a]pyridine-6-carboxamido)ethoxy)-5-oxopentanoic acid5-[2-[[8-[(2,6-dimethylphenyl)methylamino]-2,3-dimethylimidazo[1,2-a]pyridine-6-carbonyl]amino]ethoxy]-5-oxopentanoic acid
名称をさらに表示
リナプラザングルレートfast onset,Linaprazan glurate,gastric acid,gastrointestinal inflammatory diseases,peptic ulcer diseases,Inhibitor,inhibit5-[2-[[[8-[(2,6-dimethylphenyl)methylamino]-2,3-dimethyl-6-imidazo[1,2-a]pyridinyl]-oxomethyl]amino]ethoxy]-5-oxopentanoic acid
Glurate de linaprazanGlurato de linaprazanLinaprazan Impurity 8Linaprazan glurate [WHO-DD]orb1303649SCHEMBL2367993CHEMBL5095187Linaprazan glurate (USAN/INN)
データベース識別子
- CAS
1228559-81-6- PubChem CID
- 46208366
- ChEMBL
CHEMBL5095187- UNII
- 3VG4D399DT
物性
構造計算による物性
- XLogP
- 3.7
- 極性表面積
- 122 Ų
- 水素結合供与体数
- 3
- 水素結合受容体数
- 7
- 回転可能結合数
- 12
- 重原子数
- 35
- 形式電荷
- 0
- 複雑度
- 725
物理化学的性質
- 比重(密度)
- 1.25 · 1.25±0.1 g/cm3(Predicted)
- 貯蔵温度
- -20 °C · Store at -20°C
- 酸解離定数(Pka)
- 4.6 · 4.60±0.10(Predicted)
- 外見
- Solid
- 色
- White to off-white
化学と産業
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