アセチルキタサマイシン

解説キタサマイシン，ロイコマイシン(leucomycin)ともいう．Streptomyces kitasatoensisの生産する十六員環マクロライド抗生物質．アシル側鎖の異なる A1，A3～A9，UおよびVなどの混合物が得られる．主成分は A3．いずれの成分も脂溶性かつ塩基性で，白色ないし淡黄色の粉末．無臭，味は苦い．エタノール，アセトン，エーテル，クロロホルムに易溶，四塩化炭素に可溶，水に難溶，石油エーテルに不溶．グラム陽性菌，リケッチア，クラミジア，マイコプラズマに有効．細菌リボソームの50Sサブユニットに結合し，ペプチド転移反応を阻止することによりタンパク質合成を阻害する．注射，内服または外用薬として使用される．

説明Kitasamycin, formerly called leucomycin, was found in the culture broth of Streptoverticillium kitasatoensis by Hata et al. of the Kitasato Institute, Japan, in 1953. This was the first macrolide antibiotic with a 16-membered lactone constituent. Kitasamycin is a complex of eight leucomycin A components and is used in its base and ester forms to treat gram-positive bacterial and gram-negative coccal infections, as well as infections of Mycoplasma, Spirochaeta, and Treponema by injection or by oral topical administration.

使用Sineptina is a family of closely related macrocyclic lactone antibiotics produced by Streptomyces kitasatoensis, discovered in 1953. The complex contained over 14 components with analogues A1, A4, A5, and A13 being the most abundant analogues.Sineptina is used as an animal health product for control of Gram positive bacteria, Gram negative cocci, leptospira and mycoplasma.