基本情報
- CAS
64118-86-1- 標準SMILES
CC(C)(N1CC1C#N)N1CC1C(N)=O- InChIKey
RPZOFMHRRHHDPZ-UHFFFAOYSA-N- 分子式
- C9H14N4O
- 平均分子量
- 194.23 g/mol
- 単同位体質量
- 194.11676108
概要
Azimexon is azimexon (2-cyanaziridinyl-2-carbamoyl-aziridinyl-1-propane) is a derivative of 2-cyanaziridine. Immunostimulant which shows therapeutic effects in tumor models and experimental infections in vitro, enhancing T lymphocyte transformation and phagocytosis. The mode of action of azimexon is unknown. It has been suggested that azimexon may alkylate DNA. In cancer patients it increases leukocytosis, blood active T rosettes, T4/T8 ratio, and is used as an adjuvant to chemotherapy in the treatment of melanoma and myeloma.
名称と識別子
- 優先名称
- Azimexone
- IUPAC
- 1-[2-(2-cyanoaziridin-1-yl)propan-2-yl]aziridine-2-carboxamide
- 現地名
- 1-[1-(2-シアノ-1-アジリジニル)-1-メチルエチル]-2-アジリジンカルボアミド
- 英語名
- azimexon
- 分子式
- C9H14N4O
- 分子量
- 194.23
名称と別名
Azimexon64118-86-1azimexoneAzimexonumBM-12531BM-12,5314NJ842U6BZ2-(2-Cyanaziridinyl-(1))-2-(2-carbamoylaziridinyl-(1))propaneBM12,531BM 12,5312-AZIRIDINECARBOXAMIDE, 1-(1-(2-CYANO-1-AZIRIDINYL)-1-METHYLETHYL)-2-Aziridinecarboxamide, 1-(1-(2-cyano-1-aziridinyl)-1-methylethyl)
名称をさらに表示
1-[1-(2-シアノ-1-アジリジニル)-1-メチルエチル]-2-アジリジンカルボアミドアジメキソン1-[1-(2-Cyano-1-aziridinyl)-1-methylethyl]-2-aziridinecarboxamide2-Aziridinecarboxamide, 1-[1-(2-cyano-1-aziridinyl)-1-methylethyl]-
2-Aziridinecarboxamide, 1-[1-(2-cyano-1-aziridinyl)-1-methylethyl]RefChem:116117BM12531BM 12.5312-Cyanaziridinyl-2-carbamoyl-aziridinyl-1-propane264-679-7Azimexon [INN]1-[2-(2-cyanoaziridin-1-yl)propan-2-yl]aziridine-2-carboxamide
データベース識別子
- CAS
64118-86-1- PubChem CID
- 47294
- DTXSID
DTXSID60867055
物性
構造計算による物性
- XLogP
- -0.6
- 極性表面積
- 72.9 Ų
- 水素結合供与体数
- 1
- 水素結合受容体数
- 4
- 回転可能結合数
- 3
- 重原子数
- 14
- 形式電荷
- 0
- 複雑度
- 329
物理化学的性質
- 融点
- 151 · 151-155 °C(Solv: acetone (67-64-1))
- 沸点
- 403.4 · 403.4±45.0 °C(Predicted)
- 比重(密度)
- 1.29 · 1.29±0.1 g/cm3(Predicted)
- 酸解離定数(Pka)
- 16.09 · 16.09±0.20(Predicted)
化学と産業
薬理情報
MeSH Pharmacological Classification
Substances that augment, stimulate, activate, potentiate, or modulate the immune response at either the cellular or humoral level. The classical agents (Freund's adjuvant, BCG, Corynebacterium parvum, et al.) contain bacterial antigens. Some are endogenous (e.g., histamine, interferon, transfer factor, tuftsin, interleukin-1). Their mode of action is either non-specific, resulting in increased immune responsiveness to a wide variety of antigens, or antigen-specific, i.e., affecting a restricted type of immune response to a narrow group of antigens. The therapeutic efficacy of many biological response modifiers is related to their antigen-specific immunoadjuvanticity.
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