フェニルアルシン オキシド

Phenylarsine Oxide

HCID 4778CAS 637-03-6

基本情報

標準SMILES
O=[As]c1ccccc1
InChIKey
BQVCCPGCDUSGOE-UHFFFAOYSA-N
分子式
C6H5AsO
平均分子量
168.02 g/mol
単同位体質量
167.95563628

概要

Phenylarsine oxide is an arsine oxide derived from phenylarsine. It has a role as an EC 3.1.3.48 (protein-tyrosine-phosphatase) inhibitor, an antineoplastic agent and an apoptosis inducer.

名称と識別子

優先名称
Phenylarsine Oxide
IUPAC
arsorosobenzene
現地名
フェニルアルシン オキシド
英語名
Phenylarsine oxide
分子式
C6H5AsO
分子量
168.02

名称と別名

phenylarsine oxide637-03-6OxophenylarsinearsorosobenzeneArzenePhenylarsenoxideArsenosobenzeneARSINE, OXOPHENYL-Phenyl arsine oxideFenylarsinoxidPhAsODTXSID5042249
名称をさらに表示
フェニルアルシン オキシドアルゼンフェニルアルシンオキシドフェニルアルセノキシドアルセノソベンゼンオキソフェニルアルシン酸化フェニルひ素フェニルアルシン=オキシド酸化フェニルひ素, 97%PolyalphaolefinsPAOPoly α-olefinsarsenoso-benzenoxophenyl-arsin
0HUR2WY345NSC-42470DTXCID3022249CHEBI:75253RefChem:861713211-275-32-(Hydroxypropyl)phenylarsinic acidBenzene, arsenoso-

データベース識別子

CAS
637-03-6
PubChem CID
4778
DTXSID
DTXSID5042249
ChEMBL
CHEMBL477683
ChEBI
CHEBI:75253
UNII
0HUR2WY345
EC Number
211-275-3
Nikkaji
J6.913B

物性

構造計算による物性

極性表面積
17.1 Ų
水素結合供与体数
0
水素結合受容体数
1
回転可能結合数
0
重原子数
8

実験および物理化学的性質

Chemical ClassesMetals -> Arsenic Compounds, Organic
Physical DescriptionCrystals with a melting point of 144-146 degrees C; [Merck Index]

物理化学的性質

融点
145 · 145-148 °C
貯蔵温度
Poison room
溶解性
50 mg/mL · DMSO: 50 mg/mL
外見
粉
色
白から黄色
由来生物
synthetic (organic)

化学的性質

化学的特性WHITE TO ALMOST WHITE CRYSTALS OR CRYST. POWDER

安全と法規制

GHS分類

GHS Classification · 4 件

Danger

H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]

P261, P264, P270, P271, P273, P301+P316, P304+P340, P316, P321, P330, P391, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 48 reports by companies from 7 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

危険有害性情報

Regulatory Information · 2 件

Chemical: Arsine, oxophenyl-

Restricted substance: Phenylarsine oxide

Hazards Summary · 1 件

Acute or chronic arsenic poisoning may result from ingestion or inhalation of a sufficient dose; [MSDSonline] Not found in any pesticide products; [NPIRS] Almost nothing is known regarding health effects of organic arsenic compounds in humans. Studies in animals show that some simple organic arsenic compounds are less toxic than inorganic forms. Ingestion of methyl and dimethyl compounds can cause diarrhea and damage to the kidneys. [ATSDR ToxProfiles]

Hazard Classes and CategoriesAcute Tox. 3 (100%)

安全と保護具

Exposure Control and Personal Protection · 1 件

TIH (Toxic Inhalation Hazard) - Term used to describe gases and volatile liquids that are toxic when inhaled. Some are TIH materials themselves, e.g., chlorine, and some release TIH gases when spilled in water, e.g., chlorosilanes. [ERG 2016].

Permissible Exposure Limit (PEL)0.5 [mg/m3], as As

安全データ

wgk
3
tsca
TSCA listed
rtecs
CH8100000
ridadr
UN 3465 6.1/PG 3
毒性
LD50 ipr-mus: 1930 mg/kg JPETAB 74,210,42
hs_code
29310099

化学と産業

薬理情報

MeSH Pharmacological Classification · 2 件

Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.

Drugs or agents which antagonize or impair any mechanism leading to blood platelet aggregation, whether during the phases of activation and shape change or following the dense-granule release reaction and stimulation of the prostaglandin-thromboxane system.

用途と製造

UsesInhibits protein-tyrosine-phosphatase. [ChemIDplus] Used in veterinarian medicine as a poultry coccidiostat; [6949, Merck Index]
General Manufacturing InformationArsine, oxophenyl-: ACTIVE
応用分野 · 3 件

用途合成原料。

使用Phenylarsine oxide is used as a poultry coccidiostat in veterinary medicine. It is also used in a membrane-permeable protein tyrosine phosphatase inhibitor.

一般的な説明Phenylarsine oxide (PhAsO4) is a bifunctional SH group chemical. It is hydrophobic in nature.

サプライヤー50 社

梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
上海麦克林生化科技股份有限公司021-50706066 15221275939 · [email protected]
上海仲因实业有限公司2537653158 16621191650 · [email protected]
Dayang Chem (Hangzhou) Co.,Ltd.+86-0571-88938639 17705817739 · [email protected]

補足説明

定義ChEBI: An arsine oxide derived from phenylarsine.

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