フェノキサプロップ-エチル標準品

Tolerances are established for the combined residues of the herbicide fenoxaprop-ethyl [(+)-ethyl 2-[4-[(6-chloro-2- benzoxazolyl)oxy]phenoxy]propanoate] and its metabolites [2-[4-[(6-chloro- 2-benzoxazoyl)oxy]phenoxy]propanoic acid and 6-chloro-2,3- dihydrobenzoxazol-2-one], each expressed as fenoxaprop-ethyl, in or on the following raw agricultural commodities: 0.05 ppm for cottonseed; peanuts; peanut hulls; rice grain; and soybeans.

Interim tolerances, to expire April 12 1996, are established for the combined residues of the herbicide fenoxaprop-ethyl [(+)-ethyl 2-[4-[(6-chloro-2- benzoxazolyl)oxy]phenoxy]propanoate] and its metabolites [2-[4-[(6-chloro- 2-benzoxazoyl)oxy]phenoxy]propanoic acid and 6-chloro-2,3- dihydrobenzoxazol-2-one], each expressed as fenoxaprop-ethyl, in or on the following raw agricultural commodities: 0.02 ppm for milk; 0.05 ppm for cattle (fat, mbyp, and meat), goats (fat, mbyp, and meat), hogs (fat, mbyp, and meat), horses (fat, mbyp, and meat), sheep (fat, mbyp, and meat), and wheat (grain); and 0.50 ppm for wheat (straw).

Excerpt from ERG Guide 171 [Substances (Low to Moderate Hazard)]:

Wear goggles or face shield and impermeable rubber gloves while mixing. Long sleeved shirt and long pants while mixing and during application.

The persistence of (14)C fenoxaprop acid, the major degradation product of the herbicide (14)C fenoxaprop-ethyl, was studied at different controlled temperature and moisture conditions in 3 Sakatchewan soils. At 85% of field capacity, degradation approximated to first order kinetics at soil temperatures of 10, 20, and 30 °C, with halflife values ranging from 42 to 5 days. In clay at 20 °C, there was no effect of moisture, between 50 and 100% field capacity, on the rate of (14)C fenoxaprop acid breakdown. There was no loss of radioactivity after 65 days in air dry soils. In all soils incubated at 85% field capacity and 20 °C with (14)C fenoxaprop-ethyl, uniformly labeled in the chlorophenyl ring, there was evolution of (14)CO2 indicating ring fission. Over a 56 day incubation period, 10-15% of the applied radioactivity was released from the treated soils as (14)CO2. Extraction with ammoniated acetonitrile recovered 14-19% of the original radioactivity; between 3 and 5% of the initial (14)C was incorporated into soil microbial biomass, 17-25% into the fulvic acid, 7-12% into the humic acid, and 30-34% into the humin soil fractions.

The environmental persistence and fate of fenoxaprop-ethyl, a herbicide proposed for selective control of grasses in California rice, have been investigated under laboratory and field conditions. In the field, it dissipated rapidly from both water and soil, with half lives in water <4 hr and soil residues belo detectability within 6 days. The photolysis half life in sterile, distilled water was 269 hr; in field water a combination of microbial and photochemical reactions resulted in a half life of 29 hr. Products included the corresponding acid, 6-chlorobenzoxazolinone, ethyl 2-(4-hydroxyphenoxy)propanoate, and 2-(4-hydroxyphenoxy)propanoic acid. Hydrolysis was slower at pH 6.1 and 7.4 but resulted in a half life of only 8.3 hr at pH 9.1. Fenoxaprop-ethyl is essentially nonvolatile (Henry's Law constant = 3X10-7) and was bound moderately to soil (Kcc = 6800). These properties represent a near optimum for pesticide persistence.

ACCLAIM is a proprietary combination of nitrate and L-arginine that provides the beneficial cardiovascular effects of nitrates. Combining L-arginine with organic nitrates prevents the endothelial cell's depletion of L-arginine and the associated problem of nitrate tolerance. By eliminating nitrate tolerance, ACCLAIM allows patients to receive the continuous, 24-hour benefit of a potent nitrate product, thus sustaining the desired vasodilation effect.

0.32

OPP

0.0025

OPP

LD50 Mouse male oral 4670 mg/kg

LD50 Mouse female oral 5490 mg/kg

LD50 Rat male oral 2357 mg/kg

LD50 Rat female oral 2500 mg/kg

Fenoxaprop-ethyl

0.32

9000

Females 13-49 yrs

0.0025

15

Tolerances are established for the combined residues of the herbicide fenoxaprop-ethyl [(+)-ethyl 2-[4-[(6-chloro-2- benzoxazolyl)oxy]phenoxy]propanoate] and its metabolites [2-[4-[(6-chloro- 2-benzoxazoyl)oxy]phenoxy]propanoic acid and 6-chloro-2,3- dihydrobenzoxazol-2-one], each expressed as fenoxaprop-ethyl, in or on the following raw agricultural commodities: cottonseed; peanuts; peanut hulls; rice grain; and soybeans.

Interim tolerances, to expire April 12 1996, are established for the combined residues of the herbicide fenoxaprop-ethyl [(+)-ethyl 2-[4-[(6-chloro-2- benzoxazolyl)oxy]phenoxy]propanoate] and its metabolites [2-[4-[(6-chloro- 2-benzoxazoyl)oxy]phenoxy]propanoic acid and 6-chloro-2,3- dihydrobenzoxazol-2-one], each expressed as fenoxaprop-ethyl, in or on the following raw agricultural commodities: milk, cattle (fat, mbyp, and meat), goats (fat, mbyp, and meat), hogs (fat, mbyp, and meat), horses (fat, mbyp, and meat), sheep (fat, mbyp, and meat), and wheat (grain and straw).

Used as selective post-emergence herbicide for control of grassy weeds in beets, cotton, soy beans, vegetables, turf, and other crops; [HSDB]

Farming (Pesticides) [Category: Industry]

Herbicide to control grassy weeds in broadleaved crops and established turfgrass.

/Controls/ emerged annual and perennial grass weeds in such crops as beans, beets, cotton, groundnuts, potatoes, soyabeans and vegetables using 180-480 g ai/hectare.

Chronic angina and Coronary Artery Disease