データを補完しています。通常は 1 分以内に完了します
基本情報
- CAS
155141-29-0- 標準SMILES
CN(CCOc1ccc(CC2SC(=O)NC2=O)cc1)c1ccccn1.O=C(O)/C=C\C(=O)O- InChIKey
SUFUKZSWUHZXAV-BTJKTKAUSA-N- 分子式
- C22H23N3O7S
- 平均分子量
- 473.5 g/mol
- 単同位体質量
- 473.12567108
概要
Rosiglitazone Maleate is the maleate salt of rosiglitazone, an orally-active thiazolidinedione with antidiabetic properties and potential antineoplastic activity. Rosiglitazone activates peroxisome proliferator-activated receptor gamma (PPAR-gamma), a ligand-activated transcription factor, thereby inducing cell differentiation and inhibiting cell growth and angiogenesis. This agent also modulates the transcription of insulin-responsive genes, inhibits macrophage and monocyte activation, and stimulates adipocyte differentiation.
名称と識別子
- 優先名称
- Rosiglitazone Maleate
- IUPAC
- (Z)-but-2-enedioic acid;5-[[4-[2-[methyl(pyridin-2-yl)amino]ethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione
名称と別名
Rosiglitazone maleate155141-29-0BRL-49653CRosiglitzazone maleateDTXSID2023569BRL 49653CBRL-49653-CNSC-717764KX2339DP44DTXCID7035692,4-Thiazolidinedione, 5-((4-(2-(methyl-2-pyridinylamino)ethoxy)phenyl)methyl)-, (2Z)-2-butenedioate (1:1)NSC717764
名称をさらに表示
CHEBI:88922,4-Thiazolidinedione, 5-[[4-[2-(methyl-2-pyridinylamino)ethoxy]phenyl]methyl]-, (2Z)-2-butenedioate (1:1)RefChem:56530(+-)-5-((4-(2-(Methyl-2-pyridinylamino)ethoxy)phenyl)methyl)-2,4-thiazolidinedione, (Z)-2-Butenedioate (1:1)AvandiaRosiglitazone Maleate [USAN]MFCD03427306Rosiglitazone (maleate)
データベース識別子
- CAS
155141-29-0- PubChem CID
- 5281055
- DTXSID
DTXSID2023569- ChEMBL
CHEMBL843- UNII
- KX2339DP44
- EC Number
- 642-163-6
物性
構造計算による物性補完中
- 極性表面積
- 171 Ų
- 水素結合供与体数
- 3
- 水素結合受容体数
- 10
- 回転可能結合数
- 9
- 重原子数
- 33
- 形式電荷
- 0
- 複雑度
- 587
実験および物理化学的性質
Solubility68.2 [ug/mL] (The mean of the results at pH 7.4)
Human Drugs
FDA approved drugs -> Active ingredient
FDA approved drugs -> Active ingredient
安全と法規制
GHS分類
GHS Classification
Warning
H302 (20%): Harmful if swallowed [Warning Acute toxicity, oral]
P203, P261, P264, P264+P265, P270, P271, P273, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P318, P319, P321, P330, P332+P317, P337+P317, P362+P364, P391, P403+P233, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 5 reports by companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
危険有害性情報
Hazard Classes and CategoriesEye Irrit. 2 (60%)
毒性情報
Drug Induced Liver Injury
Drug Induced Liver Injury Rank (DILIrank 2.0)
Rosiglitazone maleate
vLess-DILI-concern
3
Warnings & precautions
DOI:10.1016/j.drudis.2016.02.015
化学と産業
薬理情報
MeSH Pharmacological ClassificationSubstances which lower blood glucose levels.
関連反応
5 件
化合物ノート
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