マレイン酸 クロルフェニラミン

Breast Feeding; Lactation; Milk, Human; Antihistamines; Antipruritics

FDA approved drugs -> Active ingredient

FDA approved drugs -> Active ingredient

This chemical does not meet GHS hazard criteria for 0.8% (2 of 241) of reports.

Danger

H301 (87.6%): Toxic if swallowed [Danger Acute toxicity, oral]

P260, P261, P262, P264, P264+P265, P270, P271, P280, P301+P316, P301+P317, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P354+P338, P316, P317, P319, P321, P330, P361+P364, P363, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 241 reports by companies from 19 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Danger

SYMPTOMS: Symptoms of exposure to this compound may include drowsiness, dizziness, sleeplessness, nervousness and excitability. Other symptoms may include sensitivity reactions, dry mouth, weakness, anorexia, nausea, vomiting headache, hypotension, polyuria, heartburn, diplopia, dysuria, blurred vision and dermatitis. Exposure to large amounts may lead to hallucinations, convulsions or death, especially in infants and children. There has been one report of left-sided blepharospasm and dyskinesia on the left side of the face. Other symptoms may include central nervous system depression, local anesthesia, skin sensitization, dryness of the nose and throat, abdominal pain and diarrhea. A dulling of mental alertness may also occur.

CHLORPHENIRAMINE MALEATE

Histamine-1 Receptor Antagonist [EPC]; Histamine H1 Receptor Antagonists [MoA]

CHLORPHENIRAMINE MALEATE 4MG

Histamine-1 Receptor Antagonist [EPC]; Histamine H1 Receptor Antagonists [MoA]

Agents, usually topical, that relieve itching (pruritus).

Drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine. Included here are the classical antihistaminics that antagonize or prevent the action of histamine mainly in immediate hypersensitivity. They act in the bronchi, capillaries, and some other smooth muscles, and are used to prevent or allay motion sickness, seasonal rhinitis, and allergic dermatitis and to induce somnolence. The effects of blocking central nervous system H1 receptors are not as well understood.

Agents that are used to treat allergic reactions. Most of these drugs act by preventing the release of inflammatory mediators or inhibiting the actions of released mediators on their target cells. (From AMA Drug Evaluations Annual, 1994, p475)