メナテトレノン

化学的特性A yellow crystal is extracted from acetone-ethanol or methanol-chloroform. It has a molecular weight of 580.90 and a melting point of 51-52°C. It is insoluble in water but slightly soluble in oil. It dissolves well in ethanol, ether, acetone, benzene, chloroform, and other organic solvents. However, its solubility is slightly lower than that of vitamin K1. It decomposes when exposed to strong acid, oxidants, alkalis, and light.

解説ビタミンK2ともよばれる．多くの細菌が電子伝達系でこの化合物のキノン部分の可逆的酸化還元を利用している．酸化還元電位は－74 mVでユビキノン(ビタミンE)より190 mV低い．

用途ビタミンK 製剤骨形成を促進する

説明Menatetrenone (also known as MK-4) is a manaquinone compound and a vitamin K compound which can be used as a hemostatic agent as well as adjunctive therapy for the pain of osteoporosis. It mainly takes effects through modulating the signaling of certain tyrosine kinases, thereby affecting several transcription factors including c-myc and c-fos. It is capable of inhibiting tumor cells growth through inducing apoptosis and cell cycle arrest. It can be produced via the conversion of vitamin K1 inside the body including the testes, pancreas and arterial walls.

天然物の起源Menatetrenone (vitamin K2) is widely found in green leaves and vegetables, and also in fish, meat, cheese and liver oil.

一般的な説明Menaquinone (K2), a vitamin K2 homologue with four isoprene units. It has been reported to enhance bone formation and plays a vital role in the production of blood coagulation factors.

定義ChEBI: Menaquinone-4 is a menaquinone whose side-chain contains 4 isoprene units in an all-trans-configuration. It has a role as a bone density conservation agent, a human metabolite, an antioxidant, an anti-inflammatory agent and a neuroprotective agent.