オレイン酸·エタノールアミン

FDA approved drugs -> Active ingredient

FDA approved drugs -> Active ingredient

This chemical does not meet GHS hazard criteria for 13.6% (42 of 309) of reports.

Warning

H319 (79%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]

P264+P265, P280, P305+P351+P338, and P337+P317 (click each P-code to see the statement)

Aggregated GHS information provided per 309 reports by companies from 9 notifications to the ECHA C&L Inventory.

Chemical: 9-Octadecenoic acid, (Z)-, compound with 2-aminoethanol (1:1)

REACH registered substance: Monoethanolamine oleate (EC: 218-878-0)

9-Octadecenoic acid (9Z)-, compd. with 2-aminoethanol (1:1): Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.

Drug Induced Liver Injury Rank (DILIrank 2.0)

Ethanolamine oleate

vNo-DILI-concern

0

No match

DOI:10.1016/j.drudis.2016.02.015

When injected intravenously, ethanolamine oleate acts primarily by irritation of the intimal endothelium of the vein and produces a sterile dose-related inflammatory response. This results in fibrosis and possible occlusion of the vein. Ethanolamine oleate also rapidly diffuses through the venous wall and produces a dose-related extravascular inflammatory reaction.

The oleic acid component of ethanolamine oleate is responsible for the inflammatory response, and may also activate coagulation in vivo by release of tissue factor and activation of Hageman factor. The ethanolamine component, however, may inhibit fibrin clot formation by chelating calcium, so that a procoagulant action of ethanolamine oleate has not been demonstrated.

ETHANOLAMINE OLEATE

Vascular Sclerosing Activity [PE]; Sclerosing Agent [EPC]; Sclerosing Activity [MoA]

Chemical agents injected into blood vessels and lymphatic sinuses to shrink or cause localized THROMBOSIS; FIBROSIS, and obliteration of the vessels. This treatment is applied in a number of conditions such as VARICOSE VEINS; HEMORRHOIDS; GASTRIC VARICES; ESOPHAGEAL VARICES; PEPTIC ULCER HEMORRHAGE.

After injection into an esophageal varix, ethanolamine oleate is cleared from the injection site within five minutes via the portal vein. Some of the medication also flows into the azygos vein through the periesophageal vein if more than 20 mL is injected.

Used as a sclerosing agent; [Merck Index] Used for treatment of pyogenic granuloma. [ChemIDplus] Used to make textiles, leather, and fur articles, and fabricated metal products; [ECHA REACH Registrations]