Levobunolol Hydrochloride

HCID 5284409CAS 27912-14-7

基本情報

標準SMILES: CC(C)(C)NC[C@H](O)COc1cccc2c1CCCC2=O.Cl
InChIKey: DNTDOBSIBZKFCP-YDALLXLXSA-N
分子式: C17H26ClNO3
平均分子量: 327.8 g/mol
単同位体質量: 327.16012137

概要

Levobunolol hydrochloride is a hydrochloride obtained by combining equimolar amounts of levobunolol and hydrochloric acid. A non-selective beta-adrenergic antagonist used for treatment of glaucoma. It has a role as a beta-adrenergic antagonist and an antiglaucoma drug. It contains a levobunolol(1+).

名称と識別子

優先名称: Levobunolol Hydrochloride
IUPAC: 5-[(2S)-3-(tert-butylamino)-2-hydroxypropoxy]-3,4-dihydro-2H-naphthalen-1-one;hydrochloride

名称と別名

levobunolol hydrochloride27912-14-7Levobunolol HClAkbetaBetaganDTXSID6020777W 7000ANSC-759158W-7000AO90S49LDHHDTXCID20777CHEBI:6439

名称をさらに表示

(-)-3,4-Dihydro-5-(3-(tert-butylamino)-2-hydroxypropoxy)-1(2H)-naphthalenone hydrochlorideRefChem:55472W7000A248-725-3Levobunolol (hydrochloride)Levobunolol.HClGotensin(-) -Levobunolol hydrochloride

データベース識別子

CAS: 27912-14-7
PubChem CID: 5284409
DTXSID: DTXSID6020777
ChEMBL: CHEMBL1201177
ChEBI: CHEBI:6439
UNII: O90S49LDHH
EC Number: 248-725-3

物性

構造計算による物性

極性表面積: 58.6 Å²
水素結合供与体数: 3
水素結合受容体数: 4
回転可能結合数: 6
重原子数: 22
形式電荷: 0
複雑度: 350

実験および物理化学的性質

Human Drugs · 2 件

FDA approved drugs -> Active ingredient

安全と法規制

GHS分類

GHS Classification · 5 件

This chemical does not meet GHS hazard criteria for 2.1% (1 of 48) of reports.

Warning

H302 (97.9%): Harmful if swallowed [Warning Acute toxicity, oral]

P264, P270, P301+P317, P330, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 48 reports by companies from 3 notifications to the ECHA C&L Inventory.

危険有害性情報

Hazard Classes and CategoriesAcute Tox. 4 (97.9%)

化学と産業

薬理情報

FDA Pharmacological Classification · 2 件

LEVOBUNOLOL HYDROCHLORIDE

beta-Adrenergic Blocker [EPC]; Adrenergic beta-Antagonists [MoA]

MeSH Pharmacological Classification · 2 件

Drugs that bind to but do not activate beta-adrenergic receptors thereby blocking the actions of beta-adrenergic agonists. Adrenergic beta-antagonists are used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches, and anxiety.

Drugs that inhibit the actions of the sympathetic nervous system by any mechanism. The most common of these are the ADRENERGIC ANTAGONISTS and drugs that deplete norepinephrine or reduce the release of transmitters from adrenergic postganglionic terminals (see ADRENERGIC AGENTS). Drugs that act in the central nervous system to reduce sympathetic activity (e.g., centrally acting alpha-2 adrenergic agonists, see ADRENERGIC ALPHA-AGONISTS) are included here.