Nicotine hydrochloride

· CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.

· Do not touch damaged containers or spilled material unless wearing appropriate protective clothing.

· CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.

· Do not touch damaged containers or spilled material unless wearing appropriate protective clothing.

Excerpt from ERG Guide 151 [Substances - Toxic (Non-Combustible)]:

General First Aid:

General First Aid:

· Wear positive pressure self-contained breathing apparatus (SCBA).

· Wear positive pressure self-contained breathing apparatus (SCBA).

Wear positive-pressure self-contained breathing apparatus when fighting fires involving this material.

If material is on fire or involved in a fire: Extinguish fire using agent suitable for type of surrounding fire. Material itself does not burn or burns with difficulty. Use water in flooding quantities of fog. Use foam, dry chemical, or carbon dioxide.

Generators of waste (equal to or greater than 100 kg/mo) containing this contaminant, EPA hazardous waste number P075, must conform with USEPA regulations in storage, transportation, treatment and disposal of waste.

A potential candidate for rotary kiln incineration at a temperature range of 820 to 1,600 °C and residence times of seconds for liquids and gases, and hours for solids.

A potential candidate for fluidized bed incineration at a temperature range of 450 to 980 °C and residence times of seconds for liquids and gases, and longer for solids.

Avoid breathing dusts, and fumes from burning material. Keep upwind. Avoid bodily contact with the material. ... Do not handle broken packages unless wearing appropriate personal protective equipment. Wash away any material which may have contacted the body with copious amounts of water or soap and water. ... If contact with the material is anticipated, wear appropriate chemical protective clothing.

If material is not on fire and not involved in a fire: Keep sparks, flames, and other sources of ignition away. Keep material out of water sources and sewers.

Excerpt from ERG Guide 151 [Substances - Toxic (Non-Combustible)]:

Immediate precautionary measure

Immediate precautionary measure

8 hr Time Weighted Avg (TWA): 0.5 mg/cu m, skin. /Nicotine/

Excursion Limit Recommendation: Excursions in worker exposure levels may exceed 3 times the TLV-TWA for no more than a total of 30 minutes during a work day, and under no circumstances should they exceed 5 times the TLV-TWA, provided that the TLV-TWA is not exceeded.

Excerpt from ERG Guide 151 [Substances - Toxic (Non-Combustible)]:

Wear appropriate chemical protective gloves, boots and goggles.

SRP: Contaminated protective clothing should be segregated in such a manner so that there is no direct personal contact by personnel who handle, dispose, or clean the clothing. Quality assurance to ascertain the completeness of the cleaning procedures should be implemented before the decontaminated protective clothing is returned for reuse by the workers. Contaminated clothing should not be taken home at end of shift, but should remain at employee's place of work for cleaning.

Small Fire

Small Fire

/HUMAN EXPOSURE STUDIES/ An iv dose of 1.0 mg nicotine hydrochloride ... given to 4 volunteers produced vasoconstriction of the skin and slight to moderate increase of respirations, heart rate, and blood pressure without any serious toxic effect.

/LABORATORY ANIMALS: Acute Exposure/ Systemic administration of nicotine HCl (0.5 mg/kg) /to cats/ prior to arecoline injection resulted in significant reduction in elicited attack and threat behaviors. Nicotine (0.075-0.500 mg/kg) produced a dose-dependent suppression of natural predatory behavior as well.

/LABORATORY ANIMALS: Subchronic or Prechronic Exposure/ Male mice treated with nicotine hydrochloride either acutely (5 mg/kg ip) or subchronically (5 mg/kg ip daily for 3 weeks; 25 mg/liter in drinking water for 2-3 months) showed no evidence of hepatic dysfunction, as measured by serum glutamic-pyruvic transaminase or serum alkaline phosphatase activities. Neither acute nor subchronic administration modified the hepatotoxic response to a potent hepatotoxin (carbon tetrachloride), nor that of less potent hepatotoxins chloroform or 1, 1, 1-trichloroethane, nor was the cholestatic effect of alpha-naphthylisothiocyanate modified.

/LABORATORY ANIMALS: Subchronic or Prechronic Exposure/ Sc injection of nicotine hydrochloride 2.5 mg/kg every 12 hr for 3-4 weeks into mice increased food consumption, increased wt gain, and increased the cerebral noradrenaline content from 0.630 to 0.841 gamma/g, without significantly altering body lipids or amine content of peripheral tissues.

/LABORATORY ANIMALS: Chronic Exposure or Carcinogenicity/ Solution of 0.09375 and 0.0625% nicotine-HCl and 1% nicotinic acid were administered continuously in drinking water to 7-, 5-, and 6-wk-old Swiss albino mice for the remainder of their lifetime. The consumption of the chemical resulted in no apparent carcinogenic action in the treated animals.

/LABORATORY ANIMALS: Developmental or Reproductive Toxicity/ In chick embryos treated with nicotine hydrochloride on the 2nd, 3rd, & 4th day of incubation, hearts were smaller than normal, with an irregular beat, & blood circulation was slow and erratic. In most embryos hematomas were present in heart. Several cardiac malformations were also found.

Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR as necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Nicotine and Related Compounds/

Basic treatment: Establish a patent airway (oropharyngeal or nasopharyngeal airway, if needed). Suction if necessary. Aggressive airway management may be needed. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Anticipate seizures and treat if necessary... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with 0.9% saline (NS) during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool. Administer activated charcoal ... . /Nicotine and Related Compounds/

Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious or is in respiratory distress. Monitor cardiac rhythm and treat arrhythmias if necessary ... . Start IV administration of D5W /SRP: "To keep open", minimal flow rate/. Use 0.9% saline (NS) or lactated Ringer's (LR) if signs of hypovolemia are present. For hypotension with signs of hypovolemia, administer fluid cautiously. Watch for signs of fluid overload ... . Treat seizures with diazepam or lorazepam ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Nicotine and Related Compounds/

Emergency and supportive measures: Maintain an open airway and assist ventilation if necessary. Administer supplemental oxygen. Treat seizures, coma, hypotension, hypertension, and arrhythmias if they occur. observe for at least 4-6 hours to rule out delayed toxicity, especially after skin exposure. For ingestion of intact gum tablets or transdermal patches, observe for a longer period (up to 12-24 hours). /Nicotine/

For more Antidote and Emergency Treatment (Complete) data for NICOTINE HYDROCHLORIDE (7 total), please visit the HSDB record page.

LD50 Mouse ip 13,500 mg/kg

LD50 Mouse sc 31,900 ug/kg

P075; As stipulated in 40 CFR 261.33, when nicotine and salts, as a commercial chemical product or manufacturing chemical intermediate or an off-specification commercial chemical product or a manufacturing chemical intermediate, becomes a waste, it must be managed according to federal and/or state hazardous waste regulations. Also defined as a hazardous waste is any container or inner liner used to hold this waste or any residue, contaminated soil, water, or other debris resulting from the cleanup of a spill, into water or on dry land, of this waste. Generators of small quantities of this waste may qualify for partial exclusion from hazardous waste regulations (40 CFR 261.5(e)). /Nicotine and salts/

Persons in charge of vessels or facilities are required to notify the National Response Center (NRC) immediately, when there is a release of this designated hazardous substance, in an amount equal to or greater than its reportable quantity of 100 lb or 45.4 kg. The toll free number of the NRC is (800) 424-8802. The rule for determining when notification is required is stated in 40 CFR 302.4 (section IV. D.3.b). /Nicotine and salts/