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化工社化工社 化学情報印刷レポート · 研究参考用
HCID 5284483作成日：2026年10月30日

ジブチルジチオカルバミン酸亜鉛(II)

ジブチルジチオカルバミン酸亜鉛(II) · ビス(ジブチルジチオカルバミン酸)亜鉛 · ビス(ジブチルジチオカルバミド酸)亜鉛 · ビス(ジブチルカルバモジチオ酸)亜鉛 · 亜鉛ビス(ジブチルジチオカルバマート) · ジ-N-ブチルジチオカルバミン酸亜鉛 · ジブチルジチオカルバミン酸亜鉛 · ジブチル·ジチオカルバミン酸

https://huagongshe.com/ja/chemical/5284483

ジブチルジチオカルバミン酸亜鉛(II) の分子構造式

識別子と物理属性

CAS No.136-23-2
分子式C18H36N2S4Zn
平均分子量474.1 g/mol
単同位体質量472.105276 g/mol
SMILESCCCCN(CCCC)C(=S)[S-].CCCCN(CCCC)C(=S)[S-].[Zn+2]
InChIKeyBOXSVZNGTQTENJ-UHFFFAOYSA-L
PubChem CID5284483
ChEMBLCHEMBL2373108
ChEBICHEBI:144323
EC No.205-232-8
DTXSIDDTXSID0021462
現地名ジブチルジチオカルバミン酸亜鉛(II)

化学・物理的性質

極性表面積72.7
水素結合供与体数0
水素結合受容体数4
回転可能結合数12
重原子数25
形式電荷0
複雑度112
PolymersPlastics & Rubber -> Dithiocarbamates (Rubber)
化粧品AntioxidantAntimicrobial
臭いPleasant odorwh. powd., pleasant odor
密度1.24 at 20 °C/20 °C1,21 g/cm3
Color/FormWhite powder
溶解度Sol in carbon disulfide, benzene, chloroforminsol in waterInsoluble in water100μg/L at 25℃
沸点Decomposes at 296 °C318℃[at 101 325 Pa]
DecompositionWhen heated to decomposition it emits very toxic fumes of /zinc, nitrogen , and sulfur oxides/.
融点104-108 °C104-110°C
Food Contact SubstancesFCS -> FDA Inventory of Food Contact Substances Listed in 21 CFR
Physical DescriptionWet SolidOther SolidDry PowderLarge CrystalsWhite solid with a pleasant odor[HSDB] White to cream-colored powder[MSDSonline]
蒸気圧0Pa at 25℃
貯蔵条件Inert atmosphere,Room Temperature
外観・状態個体
比重1.21
色白い
化粧品成分の機能抗酸化物質抗菌剤
InChI1S/2C9H19NS2.Zn/c2*1-3-5-7-10(9(11)12)8-6-4-2/h2*3-8H2,1-2H3,(H,11,12)/q+2/p-2
InChIKeyBOXSVZNGTQTENJ-UHFFFAOYSA-L
SMILESCCCCN(CCCC)C(=S)S[Zn]SC(=S)N(CCCC)CCCC
LogP（分配係数）2.16 at 25℃
CAS データベース136-23-2(CAS DataBase Reference)
EPAの化学物質情報Zinc dibutyldithiocarbamate (136-23-2)

化学的特性

White powder; pleasant odor. Soluble in carbon disulfide, benzene, and chloroform; insoluble in water.

安全性と法規制

GHS 分類WarningH315: Causes skin irritation [Warning Skin corrosion/irritation]P261, P264, P264+P265, P271, P272, P273, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P333+P317, P337+P317, P362+P364, P391, P403+P233, P405, and P501 (click each P-code to see the statement)H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
規制情報Chemical: Zinc, bis(dibutylcarbamodithioato-S,S')-, (T-4)-Zinc, bis(dibutylcarbamodithioato-.kappa.S,.kappa.S')-, (T-4)- is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Zinc, bis(dibutylcarbamodithioato-.kappa.S,.kappa.S')-, (T-4)- are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)REACH registered substance: Zinc bis(dibutyldithiocarbamate) (EC: 205-232-8)Butyl ziram: Does not have an individual approval but may be used under an appropriate group standard
その他の安全情報IMAP assessments - Short chain zinc dialkyldithiocarbamates: Human health tier II assessment
有害性の概要Caused minimal to no irritation to skin and eyes of rabbitsHuman patch test studies: 1.) No positive sensitizing reactions in 20 volunteers2.) Allergic responses elicited when tested on 5 individuals with rubber glove contact dermatitis[HSDB] A skin, eye, and respiratory tract irritantMay cause skin sensitization[eChemPortal: ERMAESIS] A skin, eye, and respiratory tract irritantIn chronic animal feeding studies, no significant adverse effects[IUCLID] Teratogenic when injected into chick eggsNo other data on reproductive toxicity found[REPROTOX] May cause irritation[MSDSonline] Several of the dialkyldithiocarbamates are known skin sensitizersSee Carba mix.
FDA 要件Zinc dibutyldithiocarbamate is an indirect food additive for use only as a component of adhesives.
Special ReportsEPA/Office of Pollution Prevention and ToxicsHigh Production Volume (HPV) Challenge Program's Robust Summaries and Test Plans. Available from: http://www.epa.gov/chemrtk/viewsrch.htm on Zinc, bis(dibutylcarbamodithioato-S,S')-, (T-4) as of December 28, 2004.

用途

用途

ゴム薬剤(加硫促進剤) 、潤滑油添加剤、食品包装材料の安定剤

使用

Accelerator for latex dispersions and cements, etc; ultra-accelerator for lubricating oil additive.

Hazard Classes and CategoriesSkin Irrit. 2 (100%)Hazardous to the aquatic environment (acute) - category 1STOT SE 3
State Drinking Water Standards(IL) ILLINOIS 5000 ug/L /Zinc/
州飲料水ガイドライン(AZ) ARIZONA 5000 ug/L /Zinc/(MN) MINNESOTA 2000 ug/l /Zinc/
連邦飲料水ガイドラインEPA 5000 ug/L /Zinc/
処分方法SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air qualitypotential migration in soil or watereffects on animal, aquatic, and plant lifeand conformance with environmental and public health regulations.
生態毒性値LC50 Salmo gairdneri (Rainbow troutmean weight 0.84 g, mean length 38 mm) 750 mg/L/24 hr560 mg/L/48 hr520 mg/L/96 hrstatic, dissolved oxygen 9.1 mg/L, pH 8.0, temperature 12 °C.LC50 Lepomis macrochirus (Bluegill Sunfishmean weight 0.17 g, mean length 20 mm) >1000 mg/L/24 hr880 mg/L/48 hr, 96 hrstatic, dissolved oxygen 8.4 mg/L, pH 8.0, temperature 22 °C.EC50 Daphnia magna (Water fleaimmobilization) 0.74 mg/L/48 hr /Conditions of bioassay not specified in source examined/
有害作用Skin Sensitizer - An agent that can induce an allergic reaction in the skin.
Human Toxicity Excerpts/HUMAN EXPOSURE STUDIES/ Patch testing on 20 human volunteers (14 men and 6 women ranging in age from 17 to 69) with the rubber accelerator ZDBC produced no positive reactions on initial application, no positive reactions during the course of 15 serial applications, and no positive reactions on a subsequent rechallenge. It was concluded that the test substance was not a cumulative irritant or a sensitising agent./HUMAN EXPOSURE STUDIES/ ... Dithiocarbamate type accelerators (DTCs), mercaptobenzothiazole type accelerators (MBTs) and their corresponding amines were extracted from three different brands of surgical gloves, analyzed and patch tested in five individuals diagnosed with rubber glove contact dermatitis. Positive patch tests confirmed that DTCs including zinc-dimethyldithiocarbamate, zinc-diethyldithiocarbamate, zinc-dibutyldithiocarbamate, dimethylamine, diethylamine and piperidine triggered allergic response in the subjects./SIGNS AND SYMPTOMS/ Acute zinc toxicity from excessive ingestion is uncommon, but GI distress and diarrhea have been reported following ingestion of beverages standing in galvanized cans of from the use of galvanized utensils. However, evidence of hematologic, hepatic, or renal toxicity has not been observed in individuals ingesting as much as 12 g of elemental zinc over a 2-day period. /Zinc//SIGNS AND SYMPTOMS/ Alcohol intolerance may result from exposure to dithiocarbamates. /Dithiocarbamates/For more Human Toxicity Excerpts (Complete) data for ZINC DIBUTYLDITHIOCARBAMATE (8 total), please visit the HSDB record page.
Environmental BiodegradationANAEROBIC: No biodegradation data were located for zinc dibutyldithiocarbamate(SRC). However, 68% and 17% CO2 production after 50 days with and without sediment, respectively, were reported for analogous zinc dimethyldithiocarbamate using an adapted water sediment medium(1). This suggests biodegradation under anaerobic conditions may be an important environmental fate process for zinc dibutyldithiocarbamate(SRC).
Environmental BioconcentrationNo bioconcentration data were located for zinc dibutyldithiocarbamate(SRC). However, BCFs of 90 and 4.7 were reported for analogous zinc dimethyldithiocarbamate using trout and guppies, respectively, which were exposed over a 2-week period(1). According to a classification scheme(2), these BCFs suggest the potential for bioconcentration in aquatic organisms is moderate(SRC), provided the compound is not metabolized by the organism(SRC).
Non-Human Toxicity Excerpts/LABORATORY ANIMALS: Acute Exposure/ Six young adult rabbits, ...body weights... ranged from 2.57- 2.83 kg /were studied/. Thirty-nine (39) mg of the test substance was instilled into the conjunctival sac of the right eye of each animal... . Observations for signs of irritation were conducted on days 1, 2, and 3 after dosing. The untreated eye of each animal served as a negative control. ...The Draize Method was used for scoring eye irritation. The average Draize score for 24, 48 and 72 hours was calculated for each animal and then averaged over the six animals. The average Draize score was 0.3 on a scale from 0-110. All signs of irritation had subsided by the second day after exposure./LABORATORY ANIMALS: Acute Exposure/ Six young adult /New Zealand albino/ rabbits, ...mean body weights... ranged from 2.91-3.20 kg /were studied/. The skin on the dorsal surface of each animal was shaved with an electric clipper and abraded with a hypodermic needle prior to administration of the test substance. ...A mass of 0.5 g of the test material, moistened with physiological saline, was applied to each of two intact and two abraded sites on each animal. The test material was applied to the skin under 1 inch square gauze patches and held in contact with the skin by means of an occlusive wrap of latex rubber secured by bandaging and elastic tape. The occlusive wrap and gauze patches were removed after 24 hours, and the excess test material was wiped from the treated sites of each animal. The initial (day 1) observation for skin irritation was made approximately 1 hr after removal of the wrappings. Dermal irritation was scored by the Draize Method... . The Primary Irritation Index was found to be 0.1 on a scale of 0.0-8.0. All signs of skin irritation had subsided by the third day after test material administration./LABORATORY ANIMALS: Subchronic or Prechronic Exposure/ Groups of 15 male and 15 female rats were given diet containing 0, 100, 500 or 2500 ppm zinc dibutyldithiocarbamate for 17 wk. At 2500 ppm rate of body weight gain of females and food intake of both sexes were reduced and relative liver and kidney weight of both sexes were increased. There were no effects on results of hematological exam or analyses of serum and urine. No-untoward-effect level was 500 ppm./LABORATORY ANIMALS: Subchronic or Prechronic Exposure/ Excessive zinc addition to food or water /of experimental animals/ has resulted in a variety of systemic effects in the hematological and gastrointestinal systems. Alterations in the blood lipid profile and lesions in the liver, kidney, and pancreas as well as decreased body weight gain have been reported. /Zinc/For more Non-Human Toxicity Excerpts (Complete) data for ZINC DIBUTYLDITHIOCARBAMATE (14 total), please visit the HSDB record page.
Environmental Abiotic DegradationDithiocarbamate salts are known to rapidly hydrolyze under acidic conditions. Breakdown products detected during hydrolysis experiments are the starting amine ... and carbon disulfide(1).
Antidote and Emergency TreatmentBasic treatment: Establish a patent airway. Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilation if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with normal saline during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 mL/kg up to 200 mL of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool. Administer activated charcoal ... . /Dithiocarbamates and Related Compounds/For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with normal saline during transport ... . Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious or in severe respiratory distress patient. Hyperventilate if signs of cerebral edema are present. Monitor cardiac rhythm and treat arrhythmias if necessary ... . Start an IV with D5W /SRP: "To keep open", minimal flow rate/. Use lactated Ringer's if signs of hypovolemia are present. Watch for signs of fluid overload. Treat seizures with diazepam ... . For hypotension with signs of hypovolemia, administer fluid cautiously. Consider vasopressors for hypotension with a normal fluid volume. Watch for signs of fluid overload ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Dithiocarbamates and Related Compounds/Persons who have absorbed any significant amount of thiocarbamates must avoid alcoholic beverages for at least three weeks. Disposition of thiocarbamates is slow, and their inhibitory effects on enzymes are slowly reversible. /Thiocarbamates/
Non-Human Toxicity ValuesLD50 Mouse 100 mg/kgLD50 Mouse ip >2.5 g/kg bwLD50 Rat oral >5000 mg/kg bwLD50 Rabbit (New Zealand albino) dermal >2000 mg/kg bw
水環境危害等級（WGK）WGK 2
TSCA 収載状態TSCA listed
RTECS 番号ZH0175000
輸送番号（UN）3077
毒性LD50 ipr-mus: 100 mg/kg NTIS** AD277-689
税関コード2931.90.9051
危険文句（R）36/37/38-50/53-43
化審法(2)-2122
危険表示Xi,N
安全措置（S）26-36/37/39-61-60-37-24
危険等級9Aquatic Acute 1Aquatic Chronic 1Eye Irrit. 2Skin Irrit. 2Skin Sens. 1STOT SE 3
包装等級III
貯蔵分類11 - Combustible Solids
有害物質データ136-23-2(Hazardous Substances Data)
危険度評価（NFPA 704基準/消防庁データ）人的[青]=1