4',5-ジヒドロキシ-7-(β-D-グルコピラノシルオキシ)イソフラボン

説明Genistin is a natural isoflavone isolated from legumes, including soy and kudzu. It is a phytoestrogen, as it stimulates the growth of estrogen-dependent human breast cancer cells in vivo. Like other isoflavones, genistin promotes the proliferation of bone marrow stromal cells and osteoblasts and suppresses bone turnover. It also increases bone formation in collagen matrix in vivo.

使用Genistin has been used for immune reactivity against influenza viruses in vitro and as an internal standard in isoflavones quantification.

一般的な説明Genistin belongs to the class of isoflavone glycosides generally extracted from soybeans.

純化方法Genistin is repeatedly crystallised from hot 80% EtOH/water and treated with charcoal (Nuchar) until free from saponin. The presence of saponin is detected by adding crystals to conc H2SO4 when the citron yellow colour changes to red, then purple. Pure genistin does not change colour. UV in 85% EtOH has max at 262.5nm. [Walter J Am Chem Soc 63 3273 1941, Beilstein 18 III/IV 2732.]