2-[4-[(6-クロロキノキサリン-2-イル)オキシ]フェノキシ]プロピオン酸エチル

Pesticide -> EPA IRIS

Pesticides -> Herbicides, Other

Pesticide (Quizalofop ethyl) -> USDA PDB

log Kow= 4.28

4.28

In benzene 290, xylene 120, acetone 111, ethanol 9, hexane 2.6 (all in g/l, at 20 °C)

In water, 0.3 mg/l @ 20 °C

0.00000001 [mmHg]

6.49X10-9 mm Hg @ 20 °C

Quizalofop-ethyl appears as white crystals. Insoluble in water. Used as an herbicide.

White solid; [Merck Index] Colorless solid; [HSDB]

Warning

H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]

P264, P270, P273, P280, P301+P317, P302+P352, P317, P321, P330, P362+P364, P391, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 39 reports by companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Warning

H302: Harmful if swallowed [Warning Acute toxicity, oral]

Hazard Traits - Reproductive Toxicity

Commission Regulation (EC) No 1490/2002

Propanoic acid, 2-[4-[(6-chloro-2-quinoxalinyl)oxy]phenoxy]-, ethyl ester: Does not have an individual approval but may be used under an appropriate group standard

New Active Ingredients ... includes pesticide active ingredients initially registered after November 1, 1984, that currently have active product registrations. By law, these newer pesticides are not subject to the reregistration program. They must, however, meet the new safety standard of the FQPA, and will be reviewed on a 15-year cycle under the registration review program. ... Active Ingredient Number: 128711; Type of Pesticide: conventional-herbicide; Use Site: food use and non-food use; Year: 1988.

A halogenated ester and amine. Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides. Esters react with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction of esters with caustic solutions. Flammable hydrogen is generated by mixing esters with alkali metals and hydrides.

Acute Tox. 4 (100%)

Acute toxicity (Oral) - Category 4

Tolerances are established for the combined residues of the herbicide quizalofop (2-[4-(6-chloroquinoxalin-2-yloxy)phenoxy]propanoic acid) and quizalofop ethyl (ethyl-2-[4-(6-chloroquinoxalin-2-yloxy)phenoxy]propanoate), all expressed as quizaolgop ethyl, in or on the following agricultural commodities: soybean flour 0.5 ppm; soybean hulls 0.02 ppm; soybean meal 0.5 ppm; soybean soapstock 1.0 ppm; soybeans 0.05 ppm.

Tolerances are established for the combined residues of the herbicide quizalofop (2-[4-(6-chloroquinoxalin-2-yloxy)phenoxy]propanoic acid), quizalop-ethyl (ethyl-2-[4-(6-chloroquinoxalin-2-yloxy)phenoxy]propanoate), and quizolofop-methyl (methyl-2-[4-(6-chloroquinoxalin-2-yloxy)phenoxy]propanoate), all expressed as quizalofop-ethyl, as follows: cattle, fat 0.05 ppm; cattle, meat 0.02 ppm; cattle, mbyp 0.05 ppm; eggs 0.02 ppm; goats, fat 0.05 ppm; goats, meat 0.02 ppm; goats, mbyp 0.05 ppm; hogs, fat 0.05 ppm; hogs, meat 0.02 ppm; hogs, mbyp 0.05 ppm; horses, fat 0.05 ppm; horses, meat 0.02 ppm; horses, mbyp 0.05 ppm; milk 0.01 ppm; milk, fat 0.05 ppm; poultry, fat 0.05 ppm; poultry, meat 0.02 ppm; poultry, mbyp 0.05 ppm; sheep, fat 0.05 ppm; sheep, meat 0.02 ppm; sheep, mbyp 0.05 ppm.

TERRESTRIAL FATE: Based on a classification scheme(1), Koc values of 510 and 570(2) indicate that quizalofop-ethyl is expected to have low mobility in soil(SRC). Volatilization of quizalofop-ethyl from moist soil surfaces is not expected to be an important fate process(SRC) given a Henry's Law constant of 1.1X10-8 atm-cu m/mole(SRC), based upon its vapor pressure, 6.49X10-9 mm Hg(3) and water solubility, 0.3 mg/l(4). Quizalofop-ethyl is not expected to volatilize from dry soil surfaces(SRC) based upon its vapor pressure(3). In a field dissipation study in soil, quizalofop-ethyl had a half-life of 60 days(2) suggesting that this compound is degraded fairly slowly in the environment.

AQUATIC FATE: Based on a classification scheme(1), Koc values of 510 and 570(2) indicate that quizalofop-ethyl is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces may be expected(3) based upon a Henry's Law constant of 1.1X10-8 atm-cu m/mole(SRC), based upon its vapor pressure, 6.49X10-9 mm Hg(4) and water solubility, 0.30 mg/l(5). According to a classification scheme(6), an estimated BCF of 400(SRC), from its log Kow(7) and a regression-derived equation(8), suggests the potential for bioconcentration in aquatic organisms is high(SRC). Data on the biodegradation of quizalofop-ethyl in water were not available. In a field dissipation study in soil, quizalofop-ethyl had a half-life of 60 days(2) suggesting that this compound is degraded fairly slowly in the environment.

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), quizalofop-ethyl, which has a vapor pressure of 6.49X10-9 mm Hg at 20 °C(2), is expected to exist solely in the particulate phase in the ambient atmosphere. Particulate-phase quizalofop-ethyl may be removed from the air by wet and dry deposition(SRC).

Assure

Hepatic

9 x 10 ^-3 mg/kg-day

A field dissipation half-life of 60 days was reported(1); this value includes loss due to both abiotic and biotic degradation as well as transport processes. In soil, a DT50 value of less than 1 day has been reported; quizalofop is formed as the degradation product(2).

An estimated BCF of 400 was calculated for quizalofop-ethyl(SRC), using a log Kow of 4.28(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is high(SRC).

The Henry's Law constant for quizalofop-ethyl is 1.1X10-8 atm-cu m/mole(SRC) based upon its vapor pressure, 6.49X10-9 mm Hg(1), and water solubility, 0.30 mg/l(2). This Henry's Law constant indicates that quizalofop-ethyl is expected to be essentially nonvolatile from water surfaces(3). Quizalofop-ethyl's Henry's Law constant(1,2) indicates that volatilization from moist soil surfaces should not occur(SRC). Quizalofop-ethyl is not expected to volatilize from dry soil surfaces(SRC) based upon its vapor pressure(1).

New Active Ingredients ... includes pesticide active ingredients initially registered after November 1, 1984, that currently have active product registrations. By law, these newer pesticides are not subject to the reregistration program. They must, however, meet the new safety standard of the FQPA, and will be reviewed on a 15-year cycle under the registration review program. ... Active Ingredient Number: 128711; Type of Pesticide: conventional-herbicide; Use Site: food use and non-food use; Year: 1988.

In mammals, following oral admin, the parent is rapidly metabolized; >90% of the dose is eliminated in the urine within 3 days.

Selective systemic herbicide, absorbed by the leaves, with translocation throughout the plant, moving in both the xylem & phloem. & accumulation in the meristematic tissue.

Used as selective post-emergence herbicide for control of annual and perennial grass weeds in potatoes, soy beans, sugar beets, peanuts, vegetables, cotton, and other crops; [HSDB]

Farming (Pesticides) [Category: Industry]

For Quizalofop-ethyl (USEPA/OPP Pesticide Code: 128711) ACTIVE products with label matches. /SRP: Registered for use in the U.S. but approved pesticide uses may change periodically and so federal, state and local authorities must be consulted for currently approved uses./

Systemic herbicide used for selective post-emergence control of annual and perennial grass weeds in potatos, soy beans, sugar beet, peanuts, oilseed rape, sunflowers, vegetables, cotton, and flax.

This is a man-made compound that is used as a pesticide.

USEPA/OPP Pesticide Code 128711; Trade Names: Targa, Assure, DPX-Y6202, INY-6202, NC 302, NCI-96683, FBC-32197, EXP-3864, Pilot.

Emulsifiable concentrate, suspension concentrate