ストロンチウムジクロリド

This chemical does not meet GHS hazard criteria for 3.3% (7 of 212) of reports.

Danger

H315 (24.1%): Causes skin irritation [Warning Skin corrosion/irritation]

P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P354+P338, P317, P319, P321, P332+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 212 reports by companies from 9 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Warning

Chemical: Strontium chloride (SrCl2)

Strontium chloride (SrCl2) is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Strontium chloride (SrCl2) are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

REACH registered substance: Strontium chloride (EC: 233-971-6)

Strontium chloride: Does not have an individual approval but may be used under an appropriate group standard

Causes somnolence, changes in motor activity, and diarrhea in oral lethal-dose studies of guinea pigs, mice, and rabbits; Causes ulceration of the stomach in 7-day intermittent oral studies of monkeys; Causes changes in spleen weight, changes in clotting factors, normocytic anemia, and abnormal liver function tests in repeated-dose oral studies of rats; [RTECS] A skin and strong eye irritant; [Sigma-Aldrich MSDS] See Strontium and Strontium chloride hexahydrate.

Skin Irrit. 2 (24.1%)

As an active ingredient in a toothpaste formulation, strontium chloride and the rest of the toothpaste product that it is incorporated into is designed to come into contact with and topically coat the teeth that are being brushed and is not supposed to be swallowed. The regular use of the toothpaste maintains protection that strontium chloride provides against tooth sensitivity despite the normal everyday wear, tear, and cleaning of teeth.

For dental hypersensitivity, strontium ions in strontium chloride toothpaste formulations appear to relieve pain and sensitivity by blocking fluid flow in dentinal tubules, which are essentially microscopic canals in the dentin. Regular use of such toothpastes maintains the strontium chloride barricading of the tubules despite normal everyday wear, tear, and washing of teeth.

Strontium can bind to proteins and, based on its similarity to calcium, probably forms complexes with various inorganic anions, such as carbonate and phosphate, and carboxylic acids, such as citrate and lactate. Strontium can also interact with ligands that normally bind calcium, like hypoxyapatite, the main component of mineralized bone, and a variety of calcium-binding and calcium transport proteins that are important in the physiological disposition of calcium in cells, including Ca2+ adenosine triphosphatases, Na+Ca+ antiport], and Ca2+ channels.

About 30 percent of ingested strontium is absorbed into the blood through the gut. The amount of strontium absorbed tends to decrease with age and is higher (about 60 percent) in children in their first year of life. Once it is absorbed into the blood, most of it ends up in bone; with the remainder going to soft tissues or being excreted in urine, feces, and sweat. About 8 percent of ingested strontium remains in the body after 30 days, and this decreases to about 4 percent after 1 year.