エルカ酸アミド

Based on an estimated water solubility of 0.2 mg/L and a regression equation, a log Koc value of 4.02 has been estimated for erucamide(1). This value indicates that erucamide should be immobile in soil(2) and should remain strongly adsorbed to suspended solids and sediments in water(SRC).

In a standard ASTM test to assess the biodegradation potential of chemicals, erucamide was found to be readily assimilated by fungi(1). Therefore, biodegradation of erucamide in water and soil may be important, although no rate data for biodegradation under environmental conditions are available(SRC).

The vapor pressure of erucamide has been estimated to be 1.28X10-6 mm Hg at 25 °C from its melting point of 77.5 °C(1) and an estimation method(3). The Henry's Law constant for erucamide has been estimated to be 2.844X10-6 atm-cu m/mole by an estimation method(4). From the ratio of estimated vapor pressure and estimated Henry's Law constant, the water solubility of erucamide has been estimated to be 0.2 mg/L(2). Since erucamide is a long chain aliphatic amide, it is likely to have low water solubility. The low water solubility of erucamide suggests that bioconcentration of the compound in aquatic organisms may be important(2,SRC).

A Henry's Law constant of 2.844X10-6 atm-cu m/mole has been estimated for erucamide by the bond contribution method(1). Based on this value, the volatilization of erucamide from a model river of depth 1 m, flowing at 1 m/sec and a wind speed of 3 m/sec has been estimated to be 23 days(2). Therefore, volatilization should not be important in water(SRC).

ACTION OF ERUCIC ACID ON RAT CARDIAC MYOBLASTS IN PRIMARY CELL CULTURE INDICATES AN INTENSE STEATOSIS. /EURACIC ACID/

8 OF 18 RATS FED ERUCIC ACID SHOWED MYOCARDIAL GRANULOMAS, NECROSIS, & LESIONS. /EURACIC ACID/

Amides are generally susceptible to chemical hydrolysis, but most amides without electronegative substituent on carbon or nitrogen hydrolyze extremely slowly(2). Erucamide contains chromophoric group amenable to absorption of light at wavelengths greater than 290 nm(1). Therefore, photolysis of erucamide by sunlight may be important, but rates of photolysis are unknown. The rate constant for the reaction of vapor phase erucamide with hydroxyl radicals has been estimated to be 1.03X10-10 cu-cm/molecule-sec for the cis-isomer by an estimation method(3,SRC). Assuming the daily average concn of hydroxyl radicals in the atmosphere of 5X10+5/cu-cm(4), the half-life for this reaction has been estimated to be 3.7 hrs. The rate constants for the reaction of vapor phase erucamide with atmospheric ozone have been estimated to be 13.0X10-17 cu-cm/molecule-sec(5,SRC). Assuming the daily average atmospheric concn of ozone to be 7X10+11 molecules/cu-cm(5), the half-life has been estimated to be 2.1 hrs(SRC).

Workers using erucamide during use as a foam stabilizer, solvent for fats and waxes, and antiblock agent for plastics are the most likely people for exposure to this compound(1,SRC). NIOSH (NOES Survey 1981-1983) has statistically estimated that 34,861 workers are potentially exposed to erucamide in the USA(2).

The release of erucamide in the environment is expected to occur during its industrial use as a foam stabilizer, solvent for waxes and resins, and antiblock agent for plastics. Hydrolysis of erucamide in water and soil should not be important. Based on sunlight absorption characteristics of chromophoric groups present in erucamide, photolysis in water and soil surfaces may be important, but the rates of photolysis are unknown. Erucamide was found to be readily assimilated by fungi but its biodegradation in soil and water is unknown. The estimated low vapor pressure indicates volatilization from soil may not be important. The estimated Henry's Law constant suggests that volatilization of erucamide from water should be negligible. Based upon an estimated Koc value, erucamide may have very low mobility in soil and should remain strongly sorbed to suspended solids and sediments in water. The estimated log BCF indicates bioconcentration of erucamide in aquatic organisms should be important. The estimated vapor pressure suggests that erucamide should be present both in the vapor and particulate phase in air. If present in the atmosphere in the vapor form, erucamide should react with photochemically produced hydroxyl radicals and ozone with an estimated half-life of 3.2 hrs and 2.1 hrs, respectively. Particulate erucamide salt may be partially removed from the atmosphere by dry deposition. Workers using erucamide during production of foam plastics, and waxes and resins are the most likely people for exposure to these compounds. (SRC)