(E)-1,2-ジフルオロエテン

Danger

H220 (100%): Extremely flammable gas [Danger Flammable gases]

P203, P210, P222, P280, P318, P377, P381, P403, P405, P410+P403, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 3 reports by companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

The point of departure for the Workplace Enviromental Exposure Level (WEEL) was 15,000 ppm from the 13-week rat inhalation study. After application of the adjustment factors, an 8-hour time-weighted average (TWA) WEEL value of 350 ppm was derived. This exposure limit is expected to provide a significant margin of safety against any potential adverse health effects in workers. A short-term exposure level (STEL) or skin notation is not applicable for this WEEL.

HFO-1132E has low acute toxicity following inhalation exposure in rats and dogs. It did not cause cardiac sensitization in dogs and did not cause reproductive and developmental toxicity in rats following repeated inhalation exposures. Repeated inhalation exposures for up to 13 weeks in rats found degeneration of the vomeronasal organ (VNO) at all exposure levels; however, the VNO is poorly developed or absent in humans. HFO-1132E was not genotoxic in an in vitro chromosome aberration study or in in vivo (rat) and in vitro micronucleus assays; however, it was mutagenic in some of the Salmonella and E. coli strains (with and without S9). Also, statistically significant increases in DNA strand breaks in the kidney were found at concentrations greater than or equal to 60,000 ppm, and in the liver, bladder, and lung at 120,000 ppm in an in vivo comet assay in rats; however, an increase in hedgehog cells was also noted that confounded the comet response. The full text provides additional information/perspective, e.g., the relevance of the VNO to humans is discussed in detail in the Other Information part pf the Animal Toxicity Data section.