基本情報
- CAS
101626-70-4- 標準SMILES
C=CCN1CCc2nc(N)sc2CC1- InChIKey
DHSSDEDRBUKTQY-UHFFFAOYSA-N- 分子式
- C10H15N3S
- 平均分子量
- 209.31 g/mol
- 単同位体質量
- 209.09866866
概要
6-prop-2-enyl-4,5,7,8-tetrahydrothiazolo[4,5-d]azepin-2-amine is an azepine.
名称と識別子
- 優先名称
- Talipexole
- IUPAC
- 6-prop-2-enyl-4,5,7,8-tetrahydro-[1,3]thiazolo[4,5-d]azepin-2-amine
- 現地名
- タリペキソール
- 英語名
- TALIPEXOLE
- 分子式
- C10H15N3S
- 分子量
- 209.31
名称と別名
Talipexole101626-70-4TalipexolTalipexolumDTXSID80463217AM2J46Z1YBHT920DTXCID60263216-(prop-2-en-1-yl)-4H,5H,6H,7H,8H-[1,3]thiazolo[4,5-d]azepin-2-amine6-(prop-2-en-1-yl)-4H,5H,6H,7H,8H-(1,3)thiazolo(4,5-d)azepin-2-amine4H-Thiazolo(4,5-d)azepin-2-amine, 5,6,7,8-tetrahydro-6-(2-propenyl)-, dihydrochlorideRefChem:187312
名称をさらに表示
6-アリル-2-アミノ-5,6,7,8-テトラヒドロ-4H-チアゾロ[4,5-d]アゼピンタリペキソール6-アリル-5,6,7,8-テトラヒドロ-4H-チアゾロ[4,5-d]アゼピン-2-アミン5,6,7,8-テトラヒドロ-6-(2-プロペニル)-4H-チアゾロ[4,5-d]アゼピン-2-アミン2-アミノ-6-アリル-5,6,7,8-テトラヒドロ-4H-チアゾロ[4,5-d]アゼピン6-(プロパ-2-エン-1-イル)-4H,5H,6H,7H,8H-[1,3]チアゾロ[4,5-d]アゼピン-2-アミンTalipexolum [latin]Talipexol [spanish]TALIPEXOLE USP/EP/BP6-Allyl-2-amino-5,6,7,8-tetrahydro-4H-thiazolo[4,5-d]azepine6-Allyl-5,6,7,8-tetrahydro-4H-[1,3]thiazolo[4,5-d]azepin-2-amine
BHT 9202-amino-6-allyl-5,6,7,8-tetrahydro-4H-thiazolo-(5,4-d)azepin-dihydrochloride6-allyl-2-amino-5,6,7,8-tetrahydro-4H-thiazolo(4,5-d)azepin dihydrochlorideB-HT 920Talipexole [INN]6-prop-2-enyl-4,5,7,8-tetrahydro-[1,3]thiazolo[4,5-d]azepin-2-amineDomin6-allyl-5,6,7,8-tetrahydro-4H-thiazolo[4,5-d]azepin-2-amine
物性
構造計算による物性
- XLogP
- 1.5
- 極性表面積
- 70.4 Ų
- 水素結合供与体数
- 1
- 水素結合受容体数
- 4
- 回転可能結合数
- 2
- 重原子数
- 14
- 形式電荷
- 0
- 複雑度
- 210
実験および物理化学的性質
LogP1.48
物理化学的性質
- 沸点
- 364.6 · 364.6±37.0 °C(Predicted)
- 比重(密度)
- 1.167 · 1.167±0.06 g/cm3(Predicted)
- 貯蔵温度
- -20 °C · Store at -20°C
- 溶解性
- Soluble in DMSO
- 外見
- Powder
- 酸解離定数(Pka)
- 7.22 · 7.22±0.20(Predicted)
化学と産業
薬理情報
MeSH Pharmacological Classification
Drugs that selectively bind to and activate alpha adrenergic receptors.
Mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions. Several MONOAMINE OXIDASE INHIBITORS are useful as antidepressants apparently as a long-term consequence of their modulation of catecholamine levels. The tricyclic compounds useful as antidepressive agents (ANTIDEPRESSIVE AGENTS, TRICYCLIC) also appear to act through brain catecholamine systems. A third group (ANTIDEPRESSIVE AGENTS, SECOND-GENERATION) is a diverse group of drugs including some that act specifically on serotonergic systems.
Drugs that bind to and activate dopamine receptors.
応用分野
用途ドパミンD受容体アゴニストレボドパの長期使用による副作用を軽減する
説明Domin was launched in Japan for Parkinson's disease. The compound is readily accessible in two steps from I-allylhexahydro-4H-azepin4-one. Its antiparkinson activity resides in the fact that talipexole is a selective agonist for presynaptic dopamine D2 receptors with no D1 receptor activity. It is a clonidine-like α2-adrenoreptor agonist and has fewer GI side effects than bromocriptine the most widely used dopamine angonist. Also it is 70 times more potent than bromocriptine and has a more rapid onset of action. In addition to its anti-tremor activity there was a sedative effect but no emesis. The latter probably a result of talipexole's 5-HT3 receptor antagonistic activity. Its metabolites have no biological activity, there was no development of tolerence and its effect could be enhanced by L-dopa.
上流・下流製品情報
上流原料
サプライヤー19 社
上海毕得医药科技股份有限公司400-1647117 13681763483 · [email protected]
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