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アルソロ亜酸
アルソロ亜酸 · Arsenous acid (9CI) · Arsenous acid (as As) · GCPXMJHSNVMWNM-UHFFFAOYSA-N · Carbon Dioxide in Nitrogen (Nominal Amount-of-Substance Fraction 500 μmol/mol)
識別子と物理属性
| CAS No. | 13464-58-9 |
|---|---|
| 分子式 | AsH3O3 |
| 平均分子量 | 125.944 g/mol |
| 単同位体質量 | 125.929814 g/mol |
| SMILES | O[As](O)O |
| InChIKey | GCPXMJHSNVMWNM-UHFFFAOYSA-N |
| PubChem CID | 545 |
| ChEMBL | CHEMBL1236189 |
| ChEBI | CHEBI:49900 |
| DTXSID | DTXSID7074828 |
| 現地名 | アルソロ亜酸 |
化学・物理的性質
| 極性表面積 | 60.7 |
|---|---|
| 水素結合供与体数 | 3 |
| 水素結合受容体数 | 3 |
| 回転可能結合数 | 0 |
| 重原子数 | 4 |
| 形式電荷 | 0 |
| 複雑度 | 8 |
| 物質分類 | Metals -> Arsenic Compounds, Inorganic |
| 沸点 | 465 °C |
| Physical Description | SolidV (@25 °C) |
| 外観・状態 | 溶液中にのみ存在する |
| pKa（酸解離定数） | 6.86±0.53(Predicted) |
| 色 | exists only in solution |
| EPAの化学物質情報 | Arsenous acid (13464-58-9) |
化学的特性
exists only in solution; is a weak acid, K=8×1016; structure: HO(OH)AsOH; preparation: 1 g As2O3, 5mL dilute HCl, dilute to 100mL with H2O; uses: for skin and blood disorders in animals [MER06] [KIR78]
安全性と法規制
| 有害性の概要 | See Arsenic and the linked occupational diseases. |
|---|---|
| 暴露管理・個人防護 | Biological Exposure Indices (BEI) [ACGIH] - Inorganic arsenic plus methylated metabolites in urine = 35 ug As/Lend of workweek |
| Minimum Risk Level | Acute Oral: 0.005 mg/kg/day (L134) Chronic Oral: 0.0003 mg/kg/day (L134) Chronic Inhalation: 0.01 mg/m3 (L134) |
| Threshold Limit Values (TLV) | 0.01 [mg/m3], as As |
| Permissible Exposure Limit (PEL) | 0.01 [mg/m3], as As |
| Protective Action Criteria (PAC) | 0.050 [mg/m3]0.78 [mg/m3]4.7 [mg/m3] |
| Immediately Dangerous to Life or Health (IDLH) | 5.0 [mg/m3], as As |
| Treatment | Arsenic poisoning can be treated by chelation therapy, using chelating agents such as dimercaprol, EDTA or DMSA. Charcoal tablets may also be used for less severe cases. In addition, maintaining a diet high in sulfur helps eliminate arsenic from the body. (L20) |
| 健康影響 | Arsenic poisoning can lead to death from multi-system organ failure, probably from necrotic cell death, not apoptosis. Arsenic is also a known carcinogen, esepcially in skin, liver, bladder and lung cancers. (T1, L20) |
| 有害作用 | Neurotoxin - Sensorimotor |
| 暴露経路 | Oral (L2)inhalation (L2)dermal (L2) |
| 毒性の概要 | Arsenic and its metabolites disrupt ATP production through several mechanisms. At the level of the citric acid cycle, arsenic inhibits pyruvate dehydrogenase and by competing with phosphate it uncouples oxidative phosphorylation, thus inhibiting energy-linked reduction of NAD+, mitochondrial respiration, and ATP synthesis. Hydrogen peroxide production is also increased, which might form reactive oxygen species and oxidative stress. Arsenic's carginogenicity is influenced by the arsenical binding of tubulin, which results in aneuploidy, polyploidy and mitotic arrests. The binding of other arsenic protein targets may also cause altered DNA repair enzyme activity, altered DNA methylation patterns and cell proliferation. (T1, A17) |
用途
使用
Pesticides.