基本情報
- CAS
82747-56-6- 標準SMILES
Cc1ncc2c(c1O)COC2c1ccc(Cl)cc1.Cl- InChIKey
QLMBAIRFQQLJJX-UHFFFAOYSA-N- 分子式
- C14H13Cl2NO2
- 平均分子量
- 298.2 g/mol
- 単同位体質量
- 297.032334
概要
Cicletanine Hydrochloride is the hydrochloride salt of a dihydropyridine derivative with diuretic and antihypertensive activity. Cicletanine exerts thiazide-like diuretic activity. In addition, this agent inhibits protein kinase C (PKC) and is able to reverse vasoconstriction through the inhibition of PKC-mediated inhibition of Na/K-ATPase phosphorylation.
名称と識別子
- 優先名称
- Cicletanine Hydrochloride
- IUPAC
- 3-(4-chlorophenyl)-6-methyl-1,3-dihydrofuro[3,4-c]pyridin-7-ol;hydrochloride
- 現地名
- シクレタニン塩酸塩
- 英語名
- Cicletanine hydrochloride
- 分子式
- C14H12ClNO2.ClH
- 分子量
- 298.168
名称と別名
CICLETANINE HYDROCHLORIDE82747-56-6Cicletanine HClT0SY6373OQWIN-90000 HCLWIN 90,000 HCLFuro(3,4-c)pyridin-7-ol, 3-(4-chlorophenyl)-1,3-dihydro-6-methyl-, hydrochlorideRefChem:1261013-(4-chlorophenyl)-6-methyl-1,3-dihydrofuro[3,4-c]pyridin-7-ol;hydrochloride3-(4-chlorophenyl)-6-methyl-1,3-dihydrofuro[3,4-c]pyridin-7-ol hydrochlorideCicletanine hydrochloride (JAN)Coverine
名称をさらに表示
シクレタニン塩酸塩シクレタニン塩酸塩 (JAN)塩酸シクレタニンJustarSecletanTenstaten3-(4-Chlorophenyl)-1,3-dihydro-6-methyl-furo[3,4-c]pyridin-7-ol Hydrochloride3-(4-chlorophenyl)-6-methyl-1,3-dihydrofuro[3,4-c]pyridin-7-ol hydrochloride (1:1)
3-(4-chlorophenyl)-6-methyl-1H,3H-furo[3,4-c]pyridin-7-ol hydrochlorideCICLETANINE HYDROCHLORIDE [JAN]Furosemide Impurity 22UNII-T0SY6373OQTenstaten (TN)Justar (TN)BN 1270SCHEMBL387011
物性
構造計算による物性
- 極性表面積
- 42.4 Ų
- 水素結合供与体数
- 2
- 水素結合受容体数
- 3
- 回転可能結合数
- 1
- 重原子数
- 19
- 形式電荷
- 0
- 複雑度
- 294
物理化学的性質
- 融点
- 208 · 208-219°C
- 貯蔵温度
- Refrigerator
- 溶解性
- メタノール
- 外見
- 個体
- 色
- ピンク
化学的性質
化学的特性Pink Solid
安全と法規制
安全情報は参考情報です。供給元の安全データシート（SDS）、適用法令、専門家による評価に代わるものではありません。
GHS分類
GHS Classification
This chemical does not meet GHS hazard criteria for 50% (1 of 2) of reports.
Warning
H315 (50%): Causes skin irritation [Warning Skin corrosion/irritation]
P264, P264+P265, P280, P302+P352, P305+P351+P338, P321, P332+P317, P337+P317, and P362+P364 (click each P-code to see the statement)
Aggregated GHS information provided per 2 reports by companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
危険有害性情報
Hazard Classes and CategoriesSkin Irrit. 2 (50%)
安全データ
- 危険有害性情報
- コード 危険有害性情報 危険有害性クラス 区分 注意喚起語 シンボル P コード H315
化学と産業
薬理情報
MeSH Pharmacological Classification
Agents used for the treatment or prevention of cardiac arrhythmias. They may affect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers. Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade.
Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS.
Agents that promote the excretion of urine through their effects on kidney function.
応用分野
説明Cicletanine is an antihypertensive diuretic indicated for the treatment of essential hypertension. Its unique mechanism of action is thought to involve the decrease of peripheral resistance and increase of venous compliance without modification of arterial diameter and venous tone. Chemically cicletanine belongs to a series of furopyridhes not associated with any currently known pharmacological classes.
サプライヤー12 社
Dayang Chem (Hangzhou) Co.,Ltd.+86-0571-88938639 17705817739 · [email protected]
安耐吉化学&3A（安徽泽升科技有限公司）021-58432009 400-005-6266 · [email protected]
玺标（上海）科技有限公司18512111473 18512111473 · [email protected]
Cato Research Chemicals Inc.020-81960175 · [email protected]
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